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Prevalence of anti-NT5C1A antibodies in Japanese patients with autoimmune rheumatic diseases in comparison with other patient cohorts
http://hdl.handle.net/2237/27234
http://hdl.handle.net/2237/2723416967be0-a676-4893-9383-dd24bc144ff7
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-01-09 | |||||
タイトル | ||||||
タイトル | Prevalence of anti-NT5C1A antibodies in Japanese patients with autoimmune rheumatic diseases in comparison with other patient cohorts | |||||
言語 | en | |||||
著者 |
Muro, Yoshinao
× Muro, Yoshinao× Nakanishi, Hirotaka× Katsuno, Masahisa× Kono, Michihiro× Akiyama, Masashi |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Anti-NT5C1A antibody | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dermatomyositis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ethnicity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Inclusion body myositis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Systemic autoimmune rheumatic disease | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Sporadic inclusion body myositis (sIBM) is usually classified as an idiopathic inflammatory myopathies. Although the diagnosis of sIBM is sometimes challenging, recent studies have shown that the autoantibodies against cytosolic 5′-nucleotidase 1A (NT5C1A) are the possible diagnostic biomarker for sIBM. Few reports have shown the frequencies of anti-NT5C1A antibodies in systemic autoimmune rheumatic diseases (SARDs) using large cohorts of SARDs. \nMethods: Serum samples obtained from 314 patients including dermatomyositis (DM) (n = 144), systemic lupus erythematosus (SLE) (n = 50), systemic sclerosis (SSc) (n = 50), Sjögren's syndrome (SS) (n = 50), polymyositis (PM) (n = 10) and mixed connective tissue disease (n = 10), and healthy controls (n = 42) in addition to 10 patients with typical sIBM were analysed for the presence of autoantibodies using full-length recombinant NT5C1A ELISA. \nResults: Japanese patients with DM (11%), PM (10%), SLE (6%), SSc (8%) or SS (4%) had anti-NT5C1A antibodies at lower frequencies than patients with sIBM. Interestingly, 4 of 17 DM/PM patients with anti-NT5C1A antibodies were found to have no other myositis-specific/associated autoantibodies. \nConclusions: There is a wide heterogeneity of anti-NT5C1A antibody immunoreactivity. Some populations of SARDs are positive for anti-NT5C1A are also positive for anti-NT5C1A. However, the anti-NT5C1A frequencies in the patients with SARDs are low also in Japanese. | |||||
言語 | en | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.cca.2017.07.002 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0009-8981 | |||||
書誌情報 |
en : Clinica Chimica Acta 巻 472, p. 1-4, 発行日 2017-09 |
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著者版フラグ | ||||||
値 | author | |||||
URI | ||||||
識別子 | http://doi.org/10.1016/j.cca.2017.07.002 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/27234 | |||||
識別子タイプ | HDL |