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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Prevalence of anti-NT5C1A antibodies in Japanese patients with autoimmune rheumatic diseases in comparison with other patient cohorts

http://hdl.handle.net/2237/27234
http://hdl.handle.net/2237/27234
16967be0-a676-4893-9383-dd24bc144ff7
名前 / ファイル ライセンス アクション
CCA-D-17-00599R1.pdf CCA-D-17-00599R1.pdf ファイル公開日:2018/09/01 (301.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-01-09
タイトル
タイトル Prevalence of anti-NT5C1A antibodies in Japanese patients with autoimmune rheumatic diseases in comparison with other patient cohorts
言語 en
著者 Muro, Yoshinao

× Muro, Yoshinao

WEKO 74513

en Muro, Yoshinao

Search repository
Nakanishi, Hirotaka

× Nakanishi, Hirotaka

WEKO 74514

en Nakanishi, Hirotaka

Search repository
Katsuno, Masahisa

× Katsuno, Masahisa

WEKO 74515

en Katsuno, Masahisa

Search repository
Kono, Michihiro

× Kono, Michihiro

WEKO 74516

en Kono, Michihiro

Search repository
Akiyama, Masashi

× Akiyama, Masashi

WEKO 74517

en Akiyama, Masashi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
キーワード
主題Scheme Other
主題 Anti-NT5C1A antibody
キーワード
主題Scheme Other
主題 Dermatomyositis
キーワード
主題Scheme Other
主題 Ethnicity
キーワード
主題Scheme Other
主題 Inclusion body myositis
キーワード
主題Scheme Other
主題 Systemic autoimmune rheumatic disease
抄録
内容記述 Background: Sporadic inclusion body myositis (sIBM) is usually classified as an idiopathic inflammatory myopathies. Although the diagnosis of sIBM is sometimes challenging, recent studies have shown that the autoantibodies against cytosolic 5′-nucleotidase 1A (NT5C1A) are the possible diagnostic biomarker for sIBM. Few reports have shown the frequencies of anti-NT5C1A antibodies in systemic autoimmune rheumatic diseases (SARDs) using large cohorts of SARDs. \nMethods: Serum samples obtained from 314 patients including dermatomyositis (DM) (n = 144), systemic lupus erythematosus (SLE) (n = 50), systemic sclerosis (SSc) (n = 50), Sjögren's syndrome (SS) (n = 50), polymyositis (PM) (n = 10) and mixed connective tissue disease (n = 10), and healthy controls (n = 42) in addition to 10 patients with typical sIBM were analysed for the presence of autoantibodies using full-length recombinant NT5C1A ELISA. \nResults: Japanese patients with DM (11%), PM (10%), SLE (6%), SSc (8%) or SS (4%) had anti-NT5C1A antibodies at lower frequencies than patients with sIBM. Interestingly, 4 of 17 DM/PM patients with anti-NT5C1A antibodies were found to have no other myositis-specific/associated autoantibodies. \nConclusions: There is a wide heterogeneity of anti-NT5C1A antibody immunoreactivity. Some populations of SARDs are positive for anti-NT5C1A are also positive for anti-NT5C1A. However, the anti-NT5C1A frequencies in the patients with SARDs are low also in Japanese.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.cca.2017.07.002
ISSN
収録物識別子タイプ PISSN
収録物識別子 0009-8981
書誌情報 en : Clinica Chimica Acta

巻 472, p. 1-4, 発行日 2017-09
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1016/j.cca.2017.07.002
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/27234
識別子タイプ HDL
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