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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Remote ischemic preconditioning protects human neural stem cells from oxidative stress

http://hdl.handle.net/2237/27240
http://hdl.handle.net/2237/27240
50cc935c-2996-4d72-8aee-6ae42bcfa014
名前 / ファイル ライセンス アクション
170812_figs_rIPC_Rv4.pdf 170812_figs_rIPC_Rv4.pdf ファイル公開日:2018/11/01 (10.2 MB)
161028_Motomura_A_rIPC_Rv3.pdf 161028_Motomura_A_rIPC_Rv3.pdf ファイル公開日:2018/11/01 (204.0 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-01-09
タイトル
タイトル Remote ischemic preconditioning protects human neural stem cells from oxidative stress
言語 en
著者 Motomura, Ayako

× Motomura, Ayako

WEKO 74538

en Motomura, Ayako

Search repository
Shimizu, Mikiko

× Shimizu, Mikiko

WEKO 74539

en Shimizu, Mikiko

Search repository
Kato, Akira

× Kato, Akira

WEKO 74540

en Kato, Akira

Search repository
Motomura, Kazuya

× Motomura, Kazuya

WEKO 74541

en Motomura, Kazuya

Search repository
Yamamichi, Akane

× Yamamichi, Akane

WEKO 74542

en Yamamichi, Akane

Search repository
Koyama, Hiroko

× Koyama, Hiroko

WEKO 74543

en Koyama, Hiroko

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Ohka, Fumiharu

× Ohka, Fumiharu

WEKO 74544

en Ohka, Fumiharu

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Nishikawa, Tomohide

× Nishikawa, Tomohide

WEKO 74545

en Nishikawa, Tomohide

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Nishimura, Yusuke

× Nishimura, Yusuke

WEKO 74546

en Nishimura, Yusuke

Search repository
Hara, Masahito

× Hara, Masahito

WEKO 74547

en Hara, Masahito

Search repository
Fukuda, Tetsuya

× Fukuda, Tetsuya

WEKO 74548

en Fukuda, Tetsuya

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Bando, Yasuhiko

× Bando, Yasuhiko

WEKO 74549

en Bando, Yasuhiko

Search repository
Nishimura, Toshihide

× Nishimura, Toshihide

WEKO 74550

en Nishimura, Toshihide

Search repository
Wakabayashi, Toshihiko

× Wakabayashi, Toshihiko

WEKO 74551

en Wakabayashi, Toshihiko

Search repository
Natsume, Atsushi

× Natsume, Atsushi

WEKO 74552

en Natsume, Atsushi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 The final publication is available at Springer via http://doi.org/10.1007/s11051-016-3480-4
キーワード
主題Scheme Other
主題 Remote ischemic preconditioning
キーワード
主題Scheme Other
主題 Oxygen glucose deprivation (OGD)
キーワード
主題Scheme Other
主題 Neural stem cells
キーワード
主題Scheme Other
主題 Oxidative stress
抄録
内容記述 In previous clinical trials, we showed that remote ischemic preconditioning (rIPC) reduced myocardial damage in children undergoing treatment for congenital heart defects and postoperative renal failure in patients undergoing abdominal aortic aneurysm surgery. In rabbit experiments, pre-treatment with plasma and plasma dialysate (obtained using 15-kDa cut-off dialysis membrane) from donor rabbits subjected to rIPC similarly protected against cardiac infarction. However, the protective substances containing in rIPC plasma have been unknown. In the present study, we showed that rIPC plasma exerted anti-apoptotic and anti-oxidative effects on human neural stem cells under oxygen glucose deprivation (OGD) that mimics brain ischemia. Additionally, we applied the sample to the liquid chromatography integrated with mass spectrometry to identify candidate key molecules in the rIPC plasma and determine its role in protecting neural stem cells from OGD-induced cell death. Thioredoxin increased significantly after rIPC compared to pre-IPC. Pretreatment with thioredoxin, the antioxidant protein, markedly protected human neural stem cells from OGD-induced cell death. The effect of thioredoxin on brain ischemia in animals should be further evaluated. However, the present study first evaluated the effect of rIPC in the ischemic cellular model.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s10495-017-1425-8
ISSN
収録物識別子タイプ PISSN
収録物識別子 1360-8185
書誌情報 en : Apoptosis

巻 22, 号 11, p. 1353-1361, 発行日 2017-11
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1007/s10495-017-1425-8
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/27240
識別子タイプ HDL
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