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Remote ischemic preconditioning protects human neural stem cells from oxidative stress
http://hdl.handle.net/2237/27240
http://hdl.handle.net/2237/2724050cc935c-2996-4d72-8aee-6ae42bcfa014
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-01-09 | |||||
タイトル | ||||||
タイトル | Remote ischemic preconditioning protects human neural stem cells from oxidative stress | |||||
言語 | en | |||||
著者 |
Motomura, Ayako
× Motomura, Ayako× Shimizu, Mikiko× Kato, Akira× Motomura, Kazuya× Yamamichi, Akane× Koyama, Hiroko× Ohka, Fumiharu× Nishikawa, Tomohide× Nishimura, Yusuke× Hara, Masahito× Fukuda, Tetsuya× Bando, Yasuhiko× Nishimura, Toshihide× Wakabayashi, Toshihiko× Natsume, Atsushi |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | The final publication is available at Springer via http://doi.org/10.1007/s11051-016-3480-4 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Remote ischemic preconditioning | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Oxygen glucose deprivation (OGD) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Neural stem cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Oxidative stress | |||||
抄録 | ||||||
内容記述 | In previous clinical trials, we showed that remote ischemic preconditioning (rIPC) reduced myocardial damage in children undergoing treatment for congenital heart defects and postoperative renal failure in patients undergoing abdominal aortic aneurysm surgery. In rabbit experiments, pre-treatment with plasma and plasma dialysate (obtained using 15-kDa cut-off dialysis membrane) from donor rabbits subjected to rIPC similarly protected against cardiac infarction. However, the protective substances containing in rIPC plasma have been unknown. In the present study, we showed that rIPC plasma exerted anti-apoptotic and anti-oxidative effects on human neural stem cells under oxygen glucose deprivation (OGD) that mimics brain ischemia. Additionally, we applied the sample to the liquid chromatography integrated with mass spectrometry to identify candidate key molecules in the rIPC plasma and determine its role in protecting neural stem cells from OGD-induced cell death. Thioredoxin increased significantly after rIPC compared to pre-IPC. Pretreatment with thioredoxin, the antioxidant protein, markedly protected human neural stem cells from OGD-induced cell death. The effect of thioredoxin on brain ischemia in animals should be further evaluated. However, the present study first evaluated the effect of rIPC in the ischemic cellular model. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Springer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s10495-017-1425-8 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1360-8185 | |||||
書誌情報 |
en : Apoptosis 巻 22, 号 11, p. 1353-1361, 発行日 2017-11 |
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著者版フラグ | ||||||
値 | author | |||||
URI | ||||||
識別子 | http://doi.org/10.1007/s10495-017-1425-8 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/27240 | |||||
識別子タイプ | HDL |