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Furthermore, the clinical course and progression of ALS varies widely. Brain degeneration detected using structural MRI could reflect disease progression. \\nSubjects and methods On study registration, 3-Tesla volumetric MRI and diffusion tensor imaging scans were obtained at baseline in 38 healthy controls and 67 patients with sporadic ALS. Patients had Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) scores of ≥36 and did not have the chromosome 9, open reading frame 72 repeat expansion. Six months later, changes in ALSFRS-R (ΔALSFRS-R) scores were calculated and patients were grouped into three categories, namely, patients with slow progression with ΔALSFRS-R scores ≤3 (n=19), intermediate progression with ΔALSFRS-R scores =4, 5 and 6 (n=36) and rapid progression with ΔALSFRS-R scores ≥7 (n=12). 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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Structural MRI correlates of amyotrophic lateral sclerosis progression

http://hdl.handle.net/2237/27262
http://hdl.handle.net/2237/27262
0bd8a4a5-7e6e-46a3-9780-7f4af3f7b37e
名前 / ファイル ライセンス アクション
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Supplemental Supplemental Fgure 1B.JPG (448.9 kB)
Supplemental Supplemental Fgure 1A.JPG (420.9 kB)
Supplemental Supplemental Fgure 1.JPG (600.3 kB)
Figure3.jpg Figure3.jpg (279.8 kB)
Figure2.jpg Figure2.jpg (504.3 kB)
Figure1.jpg Figure1.jpg (319.5 kB)
Manuscript_JNNP_20180112.pdf Manuscript_JNNP_20180112.pdf (398.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-01-12
タイトル
タイトル Structural MRI correlates of amyotrophic lateral sclerosis progression
言語 en
著者 Senda, Joe

× Senda, Joe

WEKO 74713

en Senda, Joe

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Atsuta, Naoki

× Atsuta, Naoki

WEKO 74714

en Atsuta, Naoki

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Watanabe, Hirohisa

× Watanabe, Hirohisa

WEKO 74715

en Watanabe, Hirohisa

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Bagarinao, Epifanio

× Bagarinao, Epifanio

WEKO 74716

en Bagarinao, Epifanio

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Imai, Kazunori

× Imai, Kazunori

WEKO 74717

en Imai, Kazunori

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Yokoi, Daichi

× Yokoi, Daichi

WEKO 74718

en Yokoi, Daichi

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Riku, Yuichi

× Riku, Yuichi

WEKO 74719

en Riku, Yuichi

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Masuda, Michihito

× Masuda, Michihito

WEKO 74720

en Masuda, Michihito

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Nakamura, Ryoichi

× Nakamura, Ryoichi

WEKO 74721

en Nakamura, Ryoichi

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Watanabe, Hazuki

× Watanabe, Hazuki

WEKO 74722

en Watanabe, Hazuki

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Ito, Mizuki

× Ito, Mizuki

WEKO 74723

en Ito, Mizuki

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Katsuno, Masahisa

× Katsuno, Masahisa

WEKO 74724

en Katsuno, Masahisa

Search repository
Naganawa, Shinji

× Naganawa, Shinji

WEKO 74725

en Naganawa, Shinji

Search repository
Sobue, Gen

× Sobue, Gen

WEKO 74726

en Sobue, Gen

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 Copyright 2017 BMJ Publishing . The following article appeared in (JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. v.88, n.11, 2017, p.901-907) and may be found at (http://dx.doi.org/10.1136/jnnp-2016-314337).
キーワード
主題Scheme Other
主題 Amyotrophic lateral sclerosis (ALS)
キーワード
主題Scheme Other
主題 progression
キーワード
主題Scheme Other
主題 voxel-based mo r p ho me t r y ( V B M)
キーワード
主題Scheme Other
主題 iffu s io n t e n s o r ima g in g ( D T I )
キーワード
主題Scheme Other
主題 fr a c t io n a l anisotropy (FA)
抄録
内容記述 Purpose Amyotrophic lateral sclerosis (ALS) presents with varying degrees of brain degeneration that can extend beyond the corticospinal tract (CST). Furthermore, the clinical course and progression of ALS varies widely. Brain degeneration detected using structural MRI could reflect disease progression. \nSubjects and methods On study registration, 3-Tesla volumetric MRI and diffusion tensor imaging scans were obtained at baseline in 38 healthy controls and 67 patients with sporadic ALS. Patients had Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) scores of ≥36 and did not have the chromosome 9, open reading frame 72 repeat expansion. Six months later, changes in ALSFRS-R (ΔALSFRS-R) scores were calculated and patients were grouped into three categories, namely, patients with slow progression with ΔALSFRS-R scores ≤3 (n=19), intermediate progression with ΔALSFRS-R scores =4, 5 and 6 (n=36) and rapid progression with ΔALSFRS-R scores ≥7 (n=12). We analysed voxel-based morphometry and tract-based spatial statistics among these subgroups and controls. \nResults In comparison with controls, patients with ALS showed grey matter atrophy and decreased fractional anisotropy beyond the motor cortex and CST, especially in the frontotemporal lobes and basal ganglia. Moreover, the degree of change was highly proportional to ΔALSFRS-R at the 6-month assessment. \nConclusion A more rapid disease progression and poorer functional decline were associated with greater involvement of the extra-motor cortex and basal ganglia, suggesting that the spatial extent of brain involvement can be an indicator of the progression in ALS.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 BMJ Publishing
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1136/jnnp-2016-314337
ISSN
収録物識別子タイプ PISSN
収録物識別子 0022-3050
書誌情報 en : JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

巻 88, 号 11, p. 901-907, 発行日 2017-11
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1136/jnnp-2016-314337
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/27262
識別子タイプ HDL
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