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Structural MRI correlates of amyotrophic lateral sclerosis progression
http://hdl.handle.net/2237/27262
http://hdl.handle.net/2237/272620bd8a4a5-7e6e-46a3-9780-7f4af3f7b37e
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-01-12 | |||||
| タイトル | ||||||
| タイトル | Structural MRI correlates of amyotrophic lateral sclerosis progression | |||||
| 言語 | en | |||||
| 著者 |
Senda, Joe
× Senda, Joe× Atsuta, Naoki× Watanabe, Hirohisa× Bagarinao, Epifanio× Imai, Kazunori× Yokoi, Daichi× Riku, Yuichi× Masuda, Michihito× Nakamura, Ryoichi× Watanabe, Hazuki× Ito, Mizuki× Katsuno, Masahisa× Naganawa, Shinji× Sobue, Gen |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | Copyright 2017 BMJ Publishing . The following article appeared in (JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. v.88, n.11, 2017, p.901-907) and may be found at (http://dx.doi.org/10.1136/jnnp-2016-314337). | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Amyotrophic lateral sclerosis (ALS) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | progression | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | voxel-based mo r p ho me t r y ( V B M) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | iffu s io n t e n s o r ima g in g ( D T I ) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | fr a c t io n a l anisotropy (FA) | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose Amyotrophic lateral sclerosis (ALS) presents with varying degrees of brain degeneration that can extend beyond the corticospinal tract (CST). Furthermore, the clinical course and progression of ALS varies widely. Brain degeneration detected using structural MRI could reflect disease progression. \nSubjects and methods On study registration, 3-Tesla volumetric MRI and diffusion tensor imaging scans were obtained at baseline in 38 healthy controls and 67 patients with sporadic ALS. Patients had Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) scores of ≥36 and did not have the chromosome 9, open reading frame 72 repeat expansion. Six months later, changes in ALSFRS-R (ΔALSFRS-R) scores were calculated and patients were grouped into three categories, namely, patients with slow progression with ΔALSFRS-R scores ≤3 (n=19), intermediate progression with ΔALSFRS-R scores =4, 5 and 6 (n=36) and rapid progression with ΔALSFRS-R scores ≥7 (n=12). We analysed voxel-based morphometry and tract-based spatial statistics among these subgroups and controls. \nResults In comparison with controls, patients with ALS showed grey matter atrophy and decreased fractional anisotropy beyond the motor cortex and CST, especially in the frontotemporal lobes and basal ganglia. Moreover, the degree of change was highly proportional to ΔALSFRS-R at the 6-month assessment. \nConclusion A more rapid disease progression and poorer functional decline were associated with greater involvement of the extra-motor cortex and basal ganglia, suggesting that the spatial extent of brain involvement can be an indicator of the progression in ALS. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | BMJ Publishing | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1136/jnnp-2016-314337 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0022-3050 | |||||
| 書誌情報 |
en : JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 巻 88, 号 11, p. 901-907, 発行日 2017-11 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
| URI | ||||||
| 識別子 | http://doi.org/10.1136/jnnp-2016-314337 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/27262 | |||||
| 識別子タイプ | HDL | |||||
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