{"_buckets": {"deposit": "0f67fa0c-9eae-44f6-b55d-206fedeac9e9"}, "_deposit": {"id": "25089", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "25089"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00025089"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "958", "bibliographicPageStart": "951", "bibliographicVolumeNumber": "63", "bibliographic_titles": [{"bibliographic_title": "CURRENT GENETICS"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "In the past decade, various transcriptional activators\nof cellulolytic enzyme genes have been identifed\nin Ascomycete fungi. The regulatory system of cellulolytic\nenzymes is not only partially conserved, but also signifcantly\ndiverse. For example, Trichoderma reesei has a\nsystem distinct from those of Aspergillus and Neurospora\ncrassa\u2014the former utilizes Xyr1 (the Aspergillus XlnR\northolog) as the major regulator of cellulolytic enzyme\ngenes, while the latter uses CLR-2/ClrB/ManR orthologs.\nXlnR/Xyr1 and CLR-2/ClrB/ManR are evolutionarily distant\nfrom each other. Regulatory mechanisms that are controlled\nby CLR-2, ClrB, and ManR are also signifcantly\ndifferent, although they are orthologous factors. Expression\nof clr-2 requires the activation of another transcription factor,\nCLR-1, by cellobiose, while CLR-2 is constitutively\nactive for transactivation. By contrast, ClrB activation\nrequires cellobiose. While ClrB mainly regulates cellulolytic\ngenes, ManR is essential for the activation of not\nonly cellulolytic but also mannanolytic enzyme genes. In\nthis review, we summarize XlnR/Xyr1- and CLR-2/ClrB/\nManR-dependent regulation in N. crassa, A. nidulans, A.\noryzae, and T. reesei and emphasize the conservation and\ndiversity of the regulatory systems for cellulolytic enzyme genes in these Ascomycete fungi. In addition, we discuss\nthe role of McmA, another transcription factor that plays\nan important role in recruiting ClrB to the promoters in A.\nnidulans.", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "http://doi.org/10.1007/s00294-017-0695-6"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/27308"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Springer"}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "The final publication is available at Springer via http://doi.org/10.1007/s00294-017-0695-6"}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0172-8083", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kunitake, Emi"}], "nameIdentifiers": [{"nameIdentifier": "74819", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobayashi, Tetsuo"}], "nameIdentifiers": [{"nameIdentifier": "74820", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-12-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Cellulase_Review_post.pdf", "filesize": [{"value": "136.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 136700.0, "url": {"label": "Cellulase_Review_post.pdf \u30d5\u30a1\u30a4\u30eb\u516c\u958b\u65e5:2018/12/01", "url": "https://nagoya.repo.nii.ac.jp/record/25089/files/Cellulase_Review_post.pdf"}, "version_id": "ad25889a-e2c8-4976-b023-11e3b1116626"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Cellulases", "subitem_subject_scheme": "Other"}, {"subitem_subject": "XlnR/Xyr1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CLR-2/ClrB/ManR", "subitem_subject_scheme": "Other"}, {"subitem_subject": "McmA", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Transcription factor", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Conservation and diversity of the regulators of cellulolytic enzyme genes in ascomycete fungi", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Conservation and diversity of the regulators of cellulolytic enzyme genes in ascomycete fungi"}]}, "item_type_id": "10", "owner": "1", "path": ["643/666/667"], "permalink_uri": "http://hdl.handle.net/2237/27308", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2018-01-30"}, "publish_date": "2018-01-30", "publish_status": "0", "recid": "25089", "relation": {}, "relation_version_is_last": true, "title": ["Conservation and diversity of the regulators of cellulolytic enzyme genes in ascomycete fungi"], "weko_shared_id": null}