{"_buckets": {"deposit": "b3291f4c-f5e1-421b-a485-2ce0cf7fbecc"}, "_deposit": {"id": "25141", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "25141"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00025141"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "12", "bibliographicPageEnd": "e85", "bibliographicPageStart": "e75", "bibliographicVolumeNumber": "17", "bibliographic_titles": [{"bibliographic_title": "Clinical Lymphoma Myeloma and Leukemia"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The existence of synchronous multiple primary malignant tumors was not a significant risk factor for patients\nwith newly diagnosed hematological malignancies. It is important to provide adequate treatment to both\nhematological malignancies and solid tumors appropriately.\nBackground: Hematological malignancies are occasionally observed with synchronous multiple primary malignant\ntumors (sMPMTs) at diagnosis. We aimed to clarify the impact of sMPMTs on newly diagnosed hematological malignancies\nand determine the optimal treatment strategies. Patients and Methods: We analyzed the outcomes of 649\npatients with hematological malignancies, including 19 patients with sMPMTs (2.9%), and compared the outcomes\nbetween patients with and without sMPMTs. Results: The overall survival (OS) and disease-free survival (DFS) rates for\npatients with sMPMTs were 77% and 70%, respectively, at 2 years; these rates were not statistically different from those\nfor patients without sMPMTs (P = .17 and P = .64, respectively). Multivariate analysis showed that the presence of\nsMPMTs was not a significant prognostic factor for OS, DFS, or relapse (hazard ratio [HR] 1.48, 95% confidence interval\n[CI] 0.65-3.38, P = .35; HR 0.97, 95% CI 0.46-2.10, P = .97; and HR 0.79, 95% CI 0.29-2.14, P= .65). In patients with\nsMPMTs, the order of treatment was not a significant prognostic factor. However, discontinuation of treatment was a\nmarginally favorable factor and might reflect a selection bias. Conclusion: The presence of sMPMTs was not a significant\nrisk factor for patients with newly diagnosed hematological malignancies. It is important to provide adequate\ntreatment for both hematological malignancies and solid tumors at the physician\u2019s discretion.", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "http://doi.org/10.1016/j.clml.2017.09.006"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/27362"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2152-2650", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nishiwaki, Satoshi"}], "nameIdentifiers": [{"nameIdentifier": "75038", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okuno, Shingo"}], "nameIdentifiers": [{"nameIdentifier": "75039", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Kotaro"}], "nameIdentifiers": [{"nameIdentifier": "75040", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kurahashi, Shingo"}], "nameIdentifiers": [{"nameIdentifier": "75041", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sugiura, Isamu"}], "nameIdentifiers": [{"nameIdentifier": "75042", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-12-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "CLML_2017_435_Original_accepted_V1.pdf", "filesize": [{"value": "359.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 359000.0, "url": {"label": "CLML_2017_435_Original_accepted_V1.pdf \u30d5\u30a1\u30a4\u30eb\u516c\u958b\u65e5: 2018/12/01", "url": "https://nagoya.repo.nii.ac.jp/record/25141/files/CLML_2017_435_Original_accepted_V1.pdf"}, "version_id": "0937d703-a1e4-46df-9616-41f02c90e7c6"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Hematological malignancies", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Order of treatment", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Solid tumors", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Synchronous multiple primary malignant tumors", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Treatment discontinuation", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Impact of Synchronous Multiple Primary Malignant Tumors on Newly Diagnosed Hematological Malignancies", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Impact of Synchronous Multiple Primary Malignant Tumors on Newly Diagnosed Hematological Malignancies"}]}, "item_type_id": "10", "owner": "1", "path": ["499/500/501"], "permalink_uri": "http://hdl.handle.net/2237/27362", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2018-02-06"}, "publish_date": "2018-02-06", "publish_status": "0", "recid": "25141", "relation": {}, "relation_version_is_last": true, "title": ["Impact of Synchronous Multiple Primary Malignant Tumors on Newly Diagnosed Hematological Malignancies"], "weko_shared_id": null}