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  1. C100 医学部/医学系研究科
  2. C100b 刊行物
  3. Nagoya journal of medical science
  4. 80(1)

Genome-wide association study for pollinosis identified two novel loci in interleukin (IL)-1B in a Japanese population

https://doi.org/10.18999/nagjms.80.1.109
https://doi.org/10.18999/nagjms.80.1.109
67441065-3c8e-418e-8578-cef3fffa20e5
名前 / ファイル ライセンス アクション
12_Fujii.pdf 12_Fujii (205.4 kB)
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Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2018-03-19
タイトル
タイトル Genome-wide association study for pollinosis identified two novel loci in interleukin (IL)-1B in a Japanese population
言語 en
著者 Fujii, Ryosuke

× Fujii, Ryosuke

WEKO 75366

en Fujii, Ryosuke

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Hishida, Asahi

× Hishida, Asahi

WEKO 75367

en Hishida, Asahi

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Wu, Michael C.

× Wu, Michael C.

WEKO 75368

en Wu, Michael C.

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Kondo, Takaaki

× Kondo, Takaaki

WEKO 75369

en Kondo, Takaaki

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Hattori, Yuta

× Hattori, Yuta

WEKO 75370

en Hattori, Yuta

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Naito, Mariko

× Naito, Mariko

WEKO 75371

en Naito, Mariko

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Endoh, Kaori

× Endoh, Kaori

WEKO 75372

en Endoh, Kaori

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Nakatochi, Masahiro

× Nakatochi, Masahiro

WEKO 75373

en Nakatochi, Masahiro

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Hamajima, Nobuyuki

× Hamajima, Nobuyuki

WEKO 75374

en Hamajima, Nobuyuki

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Kubo, Michiaki

× Kubo, Michiaki

WEKO 75375

en Kubo, Michiaki

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Kuriki, Kiyonori

× Kuriki, Kiyonori

WEKO 75376

en Kuriki, Kiyonori

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Wakai, Kenji

× Wakai, Kenji

WEKO 75377

en Wakai, Kenji

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報Resource http://creativecommons.org/licenses/by-nc-nd/4.0/
権利情報 Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
キーワード
主題Scheme Other
主題 genome-wide association study
キーワード
主題Scheme Other
主題 pollinosis
キーワード
主題Scheme Other
主題 cedar pollinosis
キーワード
主題Scheme Other
主題 cypress pollinosis
キーワード
主題Scheme Other
主題 allergic rhinitis
抄録
内容記述タイプ Abstract
内容記述 The number of pollinosis patients in Japan has significantly increased over the past 20 years. The majority of genome-wide association studies (GWAS) on pollinosis have been conducted in subjects of European descent, with few studies in Japanese populations. The aim of our GWAS was to identify genetic loci associated with self-reported pollinosis in a Japanese population and to understand its molecular background using a combination of single nucleotide polymorphisms (SNPs) and gene- and pathway-based analyses. A total of 731 and 560 individuals who were recruited as participants of the Japan Multi- Institutional Collaborative Cohort Study participated in the discovery and replication phases, respectively. The phenotype of pollinosis was based on the information from a self-administered questionnaire. In the single-SNP analysis, four SNPs (rs11975199, rs11979076, rs11979422, and rs12669708) reached suggestive significance level (P < 1 × 10^−4) and had effects in the same direction in both phases of the study. The pathway-based analysis identified two suggestive pathways (nucleotide-binding oligomerization domain -like receptor and tumor necrosis factor signaling pathways). Both rs1143633 and rs3917368 in the interleukin-1B gene showed associations in the retrace (from pathway to gene and SNP) analysis. We performed single-SNP, gene, and pathway analysis and shed light on the molecular mechanisms underlying pollinosis in a Japanese population.
言語 en
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語 en
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/nagjms.80.1.109
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/801.html
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ EISSN
収録物識別子 2186-3326
書誌情報 en : Nagoya Journal of Medical Science

巻 80, 号 1, p. 109-120, 発行日 2018-02
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