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Genome-wide association study for pollinosis identified two novel loci in interleukin (IL)-1B in a Japanese population
https://doi.org/10.18999/nagjms.80.1.109
https://doi.org/10.18999/nagjms.80.1.10967441065-3c8e-418e-8578-cef3fffa20e5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
12_Fujii (205.4 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-03-19 | |||||
| タイトル | ||||||
| タイトル | Genome-wide association study for pollinosis identified two novel loci in interleukin (IL)-1B in a Japanese population | |||||
| 言語 | en | |||||
| 著者 |
Fujii, Ryosuke
× Fujii, Ryosuke× Hishida, Asahi× Wu, Michael C.× Kondo, Takaaki× Hattori, Yuta× Naito, Mariko× Endoh, Kaori× Nakatochi, Masahiro× Hamajima, Nobuyuki× Kubo, Michiaki× Kuriki, Kiyonori× Wakai, Kenji |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報Resource | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| 権利情報 | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | genome-wide association study | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | pollinosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cedar pollinosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cypress pollinosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | allergic rhinitis | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The number of pollinosis patients in Japan has significantly increased over the past 20 years. The majority of genome-wide association studies (GWAS) on pollinosis have been conducted in subjects of European descent, with few studies in Japanese populations. The aim of our GWAS was to identify genetic loci associated with self-reported pollinosis in a Japanese population and to understand its molecular background using a combination of single nucleotide polymorphisms (SNPs) and gene- and pathway-based analyses. A total of 731 and 560 individuals who were recruited as participants of the Japan Multi- Institutional Collaborative Cohort Study participated in the discovery and replication phases, respectively. The phenotype of pollinosis was based on the information from a self-administered questionnaire. In the single-SNP analysis, four SNPs (rs11975199, rs11979076, rs11979422, and rs12669708) reached suggestive significance level (P < 1 × 10^−4) and had effects in the same direction in both phases of the study. The pathway-based analysis identified two suggestive pathways (nucleotide-binding oligomerization domain -like receptor and tumor necrosis factor signaling pathways). Both rs1143633 and rs3917368 in the interleukin-1B gene showed associations in the retrace (from pathway to gene and SNP) analysis. We performed single-SNP, gene, and pathway analysis and shed light on the molecular mechanisms underlying pollinosis in a Japanese population. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University Graduate School of Medicine, School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.80.1.109 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/801.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 80, 号 1, p. 109-120, 発行日 2018-02 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
