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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 80(1)

Intra-articular platelet-rich plasma (PRP) injections for treating knee pain associated with osteoarthritis of the knee in the Japanese population : a phase I and IIa clinical trial

https://doi.org/10.18999/nagjms.80.1.39
https://doi.org/10.18999/nagjms.80.1.39
5de52c97-6fea-4ae1-b285-b5dcef50ba2f
名前 / ファイル ライセンス アクション
05_Taniguchi.pdf 05_Taniguchi (9.6 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2018-03-19
タイトル
タイトル Intra-articular platelet-rich plasma (PRP) injections for treating knee pain associated with osteoarthritis of the knee in the Japanese population : a phase I and IIa clinical trial
著者 Taniguchi, Yu

× Taniguchi, Yu

WEKO 75459

Taniguchi, Yu

Search repository
Yoshioka, Tomokazu

× Yoshioka, Tomokazu

WEKO 75460

Yoshioka, Tomokazu

Search repository
Kanamori, Akihiro

× Kanamori, Akihiro

WEKO 75461

Kanamori, Akihiro

Search repository
Aoto, Katsuya

× Aoto, Katsuya

WEKO 75462

Aoto, Katsuya

Search repository
Sugaya, Hisashi

× Sugaya, Hisashi

WEKO 75463

Sugaya, Hisashi

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Yamazaki, Masashi

× Yamazaki, Masashi

WEKO 75464

Yamazaki, Masashi

Search repository
キーワード
主題Scheme Other
主題 platelet-rich plasma
キーワード
主題Scheme Other
主題 knee osteoarthritis
キーワード
主題Scheme Other
主題 treatment safety
キーワード
主題Scheme Other
主題 intra-articular injection
抄録
内容記述 Intra-articular platelet-rich plasma (PRP) injection has been found to be effective for treating os- teoarthritis in patients from Western countries; however, the safety and efficacy of PRP have not been sufficiently investigated in Japanese patients. The present study aimed to evaluate the safety and feasibility of intra-articular PRP injection in Japanese patients with knee osteoarthritis. PRP without white blood cells was prepared using a single-spin centrifuge (PRGF-Endoret; BTI Biotechnology Institute, Vitoria, Spain). A 6-mL PRP volume was injected in the knee joint three times at 1 week intervals. All patients were prospectively evaluated before intervention and at 1, 3, and 6 months after the treatment. Adverse events, the Visual Analog Scale (VAS) pain score, Japanese Knee Osteoarthritis Measure (JKOM) score and Japanese Orthopedic Association score were evaluated. Ten patients (all women; average age, 60.6 years) were treated. Only minor adverse events after injection were noted, and symptoms resolved within 48 hours after the injection. The average VAS pain scores were 71.6 mm and 18.4 mm at baseline and the 6-month follow-up, respectively (P < 0.05). At the 6-month follow-up, 80% of patients had a decrease in the VAS pain score of 50% or more. The average JKOM scores were 35.2 and 14.3 at baseline and at the 1-month follow-up, respectively (P < 0.05). Intra-articular PRP injection likely represents a safe treatment option for Japanese patients with mild-to-moderate knee osteoarthritis, and has the potential to relieve pain for up to 6 months, but further study is needed to verify the efficacy.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.80.1.39
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/801.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 80, 号 1, p. 39-51, 発行日 2018-02
著者版フラグ
値 publisher
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