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We previously discovered elevated levels of m/z 4588 and m/z 4473 peptides in cerebrospinal fluid (CSF) in patients with MMD. This study examined the amino acid sequences of these peptides and quantified in specimens. Methods: The m/z 4588 and m/z 4473 peptides in CSF from patients with MMD were purified and concentrated by high-performance liquid chromatography and ultrafiltration. Liquid chromatography coupled with tandem mass spectrometry analysis was performed to identify the amino acid sequences of these peptides. We quantified these peptides in samples using sandwich enzyme-linked immunosorbent assay, and concentrations in CSF were compared between MMD (n = 40, 19 male; median age, 37 years) and non-MMD intracranial disease (n = 40, 19 male; median age, 39 years) as controls. Results: These peptides were identified as proenkephalin 143-183 (PENK 143–183). 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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Elevation of Proenkephalin 143–183 in Cerebrospinal Fluid in Moyamoya Disease

http://hdl.handle.net/2237/00027918
http://hdl.handle.net/2237/00027918
a8a6938a-fa50-4e07-ba67-46ad08865d85
名前 / ファイル ライセンス アクション
Elevation_of_Proenkephalin_143-183.pdf Elevation_of_Proenkephalin_143-183 (994.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-04-17
タイトル
タイトル Elevation of Proenkephalin 143–183 in Cerebrospinal Fluid in Moyamoya Disease
言語 en
著者 Yokoyama, Kinya

× Yokoyama, Kinya

WEKO 76163

en Yokoyama, Kinya

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Maruwaka, Mikio

× Maruwaka, Mikio

WEKO 76164

en Maruwaka, Mikio

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Yoshikawa, Kazuhiro

× Yoshikawa, Kazuhiro

WEKO 76165

en Yoshikawa, Kazuhiro

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Araki, Yoshio

× Araki, Yoshio

WEKO 76166

en Araki, Yoshio

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Okamoto, Sho

× Okamoto, Sho

WEKO 76167

en Okamoto, Sho

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Sumitomo, Masaki

× Sumitomo, Masaki

WEKO 76168

en Sumitomo, Masaki

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Kawamura, Akino

× Kawamura, Akino

WEKO 76169

en Kawamura, Akino

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Sakamoto, Yusuke

× Sakamoto, Yusuke

WEKO 76170

en Sakamoto, Yusuke

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Shimizu, Kenzo

× Shimizu, Kenzo

WEKO 76171

en Shimizu, Kenzo

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Izumi, Takashi

× Izumi, Takashi

WEKO 76172

en Izumi, Takashi

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Wakabayashi, Toshihiko

× Wakabayashi, Toshihiko

WEKO 76173

en Wakabayashi, Toshihiko

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
キーワード
主題Scheme Other
主題 Angiogenesis
キーワード
主題Scheme Other
主題 Cerebrospinal fluid
キーワード
主題Scheme Other
主題 Moyamoya disease
キーワード
主題Scheme Other
主題 Peptide
キーワード
主題Scheme Other
主題 Proenkephalin
抄録
内容記述 Background: In moyamoya disease (MMD), the causes of differences in clinical features between children and adults and of the dramatic temporal changes in moyamoya vessels are poorly understood. We previously discovered elevated levels of m/z 4588 and m/z 4473 peptides in cerebrospinal fluid (CSF) in patients with MMD. This study examined the amino acid sequences of these peptides and quantified in specimens. Methods: The m/z 4588 and m/z 4473 peptides in CSF from patients with MMD were purified and concentrated by high-performance liquid chromatography and ultrafiltration. Liquid chromatography coupled with tandem mass spectrometry analysis was performed to identify the amino acid sequences of these peptides. We quantified these peptides in samples using sandwich enzyme-linked immunosorbent assay, and concentrations in CSF were compared between MMD (n = 40, 19 male; median age, 37 years) and non-MMD intracranial disease (n = 40, 19 male; median age, 39 years) as controls. Results: These peptides were identified as proenkephalin 143-183 (PENK 143–183). The concentration of PENK 143–183 was significantly greater in patients with MMD (median, 8,270 pmol/L) than control patients (median, 3,760 pmol/L; P < 0.001) and decreased in an age-dependent manner in MMD (r = −0.57; P < 0.001). The area under the receiver operating characteristic curve in children (age <18 years) was 0.885 (95% confidence interval 0.741–1). The correlation between proenkephalin concentration and temporal changes in moyamoya vessels was suggested. Conclusions: Proenkephalin 143–183 in CSF may offer a helpful diagnostic biomarker in pediatric MMD. The effect of enkephalin peptides through opioid growth factor receptor or delta opioid receptor might be associated with the pathophysiology of MMD.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開日: 2019/01/01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.wneu.2017.09.204
ISSN
収録物識別子タイプ PISSN
収録物識別子 18788750
書誌情報 en : World Neurosurgery

巻 109, p. e446-e459, 発行日 2018-01
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