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The hypothalamic–pituitary–thyroid axis and biological rhythms: The discovery of TSH's unexpected role using animal models
http://hdl.handle.net/2237/00027929
http://hdl.handle.net/2237/00027929604ce560-4511-4cff-bacb-6e07d1297063
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Ikegami-Yoshimura_BestPractice (866.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-04-23 | |||||
| タイトル | ||||||
| タイトル | The hypothalamic–pituitary–thyroid axis and biological rhythms: The discovery of TSH's unexpected role using animal models | |||||
| 言語 | en | |||||
| 著者 |
Ikegami, Keisuke
× Ikegami, Keisuke× Yoshimura, Takashi |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | seasonal reproduction | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | photoperiod | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | pars tuberalis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | glycosylation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | amphibian metamorphosis | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Thyroid hormones (TH) are important for development, growth, and metabolism. It is also clear that the synthesis and secretion of TH are regulated by the hypothalamic–pituitary–thyroid (HPT) axis. Animal models have helped advance our understanding of the roles and regulatory mechanisms of TH. The animals' bodies develop through coordinated timing of cell division and differentiation. Studies of frog metamorphosis led to the discovery of TH and their role in development. However, to adapt to rhythmic environmental changes, animals also developed various endocrine rhythms. Studies of rodents clarified the neural and molecular mechanisms underlying the circadian regulation of the HPT axis. Moreover, birds have a sophisticated seasonal adaptation mechanism, and recent studies of quail revealed unexpected roles for thyroid-stimulating hormone (TSH) and TH in the seasonal regulation of reproduction. Interestingly, this mechanism is conserved in mammals. Thus, we review how animal studies have shaped our general understanding of the HPT axis in relation to biological rhythms. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ファイル公開：2018-10-01 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.beem.2017.09.002 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1521690X | |||||
| 書誌情報 |
en : Best Practice & Research Clinical Endocrinology & Metabolism 巻 31, 号 5, p. 475-485, 発行日 2017-10 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
