{"_buckets": {"deposit": "99a02d3c-12d9-4e33-8612-0b6d8ff7b947"}, "_deposit": {"id": "26018", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "26018"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00026018"}, "item_9_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "215", "bibliographicPageStart": "207", "bibliographicVolumeNumber": "80", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science"}]}]}, "item_9_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "We investigated the association between CYP2C19 genotype and additional effect of cilostazol on clopidogrel resistance (CR) in neuroendovascular therapy. Between January 2012 and January 2016, 447 consecutive patients were administered with 75-mg cilostazol/day. The VerifyNow System was used for evaluating P2Y12 reaction units (PRU) \u003e 230 and/or percentage inhibition of platelet function (% Inhibi- tion) \u2264 20 as CR. Among 158 patients with CR, 31 were administered with additional 100- or 200-mg cilostazol/day and their platelet function was evaluated. According to CYP2C19 genotypes revealed using the Spartan RX and DNeasy Blood \u0026 Tissue Kit, patients were classified into three phenotypic groups: extensive metabolizer (EM, three patients), intermediate metabolizer (IM, 12 patients), and poor metabolizer (PM, 16 patients). Administration of additional cilostazol decreased PRU (EM group: 160.7 \u00b1 85.2 after vs 278.3 \u00b1 40.1 before, P = 0.15; IM group: 205.6 \u00b1 74.0 vs 254.3 \u00b1 35.0, P = 0.02; and PM group: 227.8 \u00b1 52.2 vs 282.1 \u00b1 30.4, P = 0.003), and increased % Inhibition (EM group: 40.0 \u00b1 27.9 vs 9.3 \u00b1 3.8, P = 0.25; IM group: 31.4 \u00b1 18.0 vs 11.8 \u00b1 8.2, P = 0.001; and PM group: 24.6 \u00b1 15.0 vs 10.4 \u00b1 9.3, P = 0.001). However, the rate of normalized-clopidogrel response, thromboembolic lesions, and bleeding complications were not significantly different among the three groups. Thus, the addition of cilostazol was effective on CR in terms of PRU, % Inhibition, rate of change of normalized-clopidogrel response, thromboembolic events, and bleeding complications irrespective of phenotype. ", "subitem_description_type": "Abstract"}]}, "item_9_identifier_registration": {"attribute_name": "ID\u767b\u9332", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.80.2.207", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University Graduate School of Medicine, School of Medicine"}]}, "item_9_relation_43": {"attribute_name": "\u7570\u7248\u3067\u3042\u308b", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/802.html ", "subitem_relation_type_select": "URI"}}]}, "item_9_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_7": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tajima, Hayato"}], "nameIdentifiers": [{"nameIdentifier": "77282", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Izumi, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "77283", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyachi, Shigeru"}], "nameIdentifiers": [{"nameIdentifier": "77284", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsubara, Noriaki"}], "nameIdentifiers": [{"nameIdentifier": "77285", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Masashi"}], "nameIdentifiers": [{"nameIdentifier": "77286", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Imai, Tasuku"}], "nameIdentifiers": [{"nameIdentifier": "77287", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishihori, Masahiro"}], "nameIdentifiers": [{"nameIdentifier": "77288", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shintai, Kazunori"}], "nameIdentifiers": [{"nameIdentifier": "77289", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okamoto, Sho"}], "nameIdentifiers": [{"nameIdentifier": "77290", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Araki, Yoshio"}], "nameIdentifiers": [{"nameIdentifier": "77291", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kumakura, Yasuo"}], "nameIdentifiers": [{"nameIdentifier": "77292", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Furukawa-Hibi, Yoko"}], "nameIdentifiers": [{"nameIdentifier": "77293", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamada, Kiyofumi"}], "nameIdentifiers": [{"nameIdentifier": "77294", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wakabayashi, Toshihiko"}], "nameIdentifiers": [{"nameIdentifier": "77295", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-05-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "07_Tajima.pdf", "filesize": [{"value": "415.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 415600.0, "url": {"label": "07_Tajima.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/26018/files/07_Tajima.pdf"}, "version_id": "771e8640-0830-4c87-8b40-f526188bcf12"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "CYP2C19 genotype", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cilostazol", "subitem_subject_scheme": "Other"}, {"subitem_subject": "clopidogrel resistance", "subitem_subject_scheme": "Other"}, {"subitem_subject": "endovascular treatment", "subitem_subject_scheme": "Other"}, {"subitem_subject": "VerifyNow System", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Association between CYP2C19 genotype and the additional effect of cilostazol to clopidogrel resistance in neuroendovascular therapy", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Association between CYP2C19 genotype and the additional effect of cilostazol to clopidogrel resistance in neuroendovascular therapy"}]}, "item_type_id": "9", "owner": "1", "path": ["499/508/509/2091"], "permalink_uri": "https://doi.org/10.18999/nagjms.80.2.207", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2018-05-28"}, "publish_date": "2018-05-28", "publish_status": "0", "recid": "26018", "relation": {}, "relation_version_is_last": true, "title": ["Association between CYP2C19 genotype and the additional effect of cilostazol to clopidogrel resistance in neuroendovascular therapy"], "weko_shared_id": 3}