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Prognostic analysis according to the 2017 ELN risk stratification by genetics in adult acute myeloid leukemia patients treated in the Japan Adult Leukemia Study Group (JALSG) AML201 study
http://hdl.handle.net/2237/00028295
http://hdl.handle.net/2237/000282958a009340-6081-4cfe-abb2-0849a71cde0f
名前 / ファイル | ライセンス | アクション |
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Harada_et_al (3.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-06-12 | |||||
タイトル | ||||||
タイトル | Prognostic analysis according to the 2017 ELN risk stratification by genetics in adult acute myeloid leukemia patients treated in the Japan Adult Leukemia Study Group (JALSG) AML201 study | |||||
言語 | en | |||||
著者 |
Harada, Yasuhiko
× Harada, Yasuhiko× Nagata, Yasunobu× Kihara, Rika× Ishikawa, Yuichi× Asou, Norio× Ohtake, Shigeki× Miyawaki, Shuichi× Sakura, Toru× Ozawa, Yukiyasu× Usui, Noriko× Kanamori, Heiwa× Ito, Yoshikazu× Imai, Kiyotoshi× Suehiro, Youko× Kobayashi, Shinichi× Kitamura, Kunio× Sakaida, Emiko× Onizuka, Makoto× Takeshita, Akihiro× Ishida, Fumihiro× Suzushima, Hitoshi× Ishizawa, Kenichi× Naoe, Tomoki× Matsumura, Itaru× Miyazaki, Yasushi× Ogawa, Seishi× Kiyoi, Hitoshi |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Many genetic alterations that are associated with the prognosis of acute myeloid leukemia (AML) have been identified, and several risk stratification systems based on the genetic status have been recommended. The European LeukemiaNet (ELN) first proposed the risk stratification system for AML in 2010 (ELN-2010), and recently published the revised system (ELN-2017). We validated the long-term prognosis and clinical characteristics of each ELN-2017 risk category in Japanese adult AML patients who were treated in the Japan Adult Leukemia Study Group (JALSG) AML-201 study. We demonstrated that the 3-risk category system of the ELN-2017 successfully discriminated the overall survival and complete remission rates in our cohort in comparison with the 4-risk category of the ELN-2010. However, there were still genetic categories in which stratification of patients into favorable or intermediate risk categories was controversial; the low allelic ratio of FLT3-ITD was not necessarily associated with a better prognosis in patients with FLT3-ITD, and cytogenetic abnormalities may affect the prognosis in patients with favorable genetic lesions such as NPM1 and CEBPA mutations. As many molecular targeting agents, such as FLT3 inhibitors, have been developed, we must continue to modify the genetic risk stratification system to match the progression of therapeutic strategies. | |||||
言語 | en | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | ファイル公開:2019-03-01 | |||||
言語 | ja | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.leukres.2018.01.008 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0145-2126 | |||||
書誌情報 |
en : Leukemia Research 巻 66, p. 20-27, 発行日 2018-03 |
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著者版フラグ | ||||||
値 | author |