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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Immunohistochemical ATRX expression is not a surrogate for 1p19q codeletion

http://hdl.handle.net/2237/00028433
e11ec53c-64b3-4a3c-a414-ed1af5c46b4d
名前 / ファイル ライセンス アクション
BTPA-S-18-00028-3.pdf BTPA-S-18-00028-3 (2.7 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-08-07
タイトル
タイトル Immunohistochemical ATRX expression is not a surrogate for 1p19q codeletion
著者 Yamamichi, Akane

× Yamamichi, Akane

WEKO 78679

Yamamichi, Akane

Search repository
Ohka, Fumiharu

× Ohka, Fumiharu

WEKO 78680

Ohka, Fumiharu

Search repository
Aoki, Kosuke

× Aoki, Kosuke

WEKO 78681

Aoki, Kosuke

Search repository
Suzuki, Hiromichi

× Suzuki, Hiromichi

WEKO 78682

Suzuki, Hiromichi

Search repository
Kato, Akira

× Kato, Akira

WEKO 78683

Kato, Akira

Search repository
Hirano, Masaki

× Hirano, Masaki

WEKO 78684

Hirano, Masaki

Search repository
Motomura, Kazuya

× Motomura, Kazuya

WEKO 78685

Motomura, Kazuya

Search repository
Tanahashi, Kuniaki

× Tanahashi, Kuniaki

WEKO 78686

Tanahashi, Kuniaki

Search repository
Chalise, Lushun

× Chalise, Lushun

WEKO 78687

Chalise, Lushun

Search repository
Maeda, Sachi

× Maeda, Sachi

WEKO 78688

Maeda, Sachi

Search repository
Wakabayashi, Toshihiko

× Wakabayashi, Toshihiko

WEKO 78689

Wakabayashi, Toshihiko

Search repository
Kato, Yukinari

× Kato, Yukinari

WEKO 78690

Kato, Yukinari

Search repository
Natsume, Atsushi

× Natsume, Atsushi

WEKO 78691

Natsume, Atsushi

Search repository
権利
権利情報 “This is a post-peer-review, pre-copyedit version of an article published in [Brain Tumor Pathology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10014-018-0312-5”.
抄録
内容記述 The IDH-mutant and 1p/19q co-deletion (1p19q codel) provides significant diagnostic and prognostic value in lower-grade gliomas. As ATRX mutation and 1p19q codel are mutually exclusive, ATRX immunohistochemistry (IHC) may substitute for 1p19q codel, but this has not been comprehensively examined. In the current study, we performed ATRX-IHC in 78 gliomas whose ATRX statuses were comprehensively determined by whole exome sequencing. Among the 60 IHC-positive and 18 IHC-negative cases, 86.7 and 77.8% were ATRX-wildtype and ATRX-mutant, respectively. ATRX mutational patterns were not consistent with ATRX-IHC. If our cohort had only used IDH status and IHC-based ATRX expression for diagnosis, 78 tumors would have been subtyped as 48 oligodendroglial tumors, 16 IDH-mutant astrocytic tumors, and 14 IDH-wildtype astrocytic tumors. However, when the 1p19q codel test was performed following ATRX-IHC, 8 of 48 ATRX-IHC-positive tumors were classified as “1p19q non-codel” and 3 of 16 ATRX-IHC-negative tumors were classified as “1p19q codel”; a total of 11 tumors (14%) were incorrectly classified. In summary, we observed dissociation between ATRX-IHC and actual 1p19q codel in 11 of 64 IDH-mutant LGGs. In describing the complex IHC expression of ATRX somatic mutations, our results indicate the need for caution when using ATRX-IHC as a surrogate of 1p19q status.
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2019/04/01
内容記述タイプ Other
出版者
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s10014-018-0312-5
ISSN
収録物識別子タイプ ISSN
収録物識別子 1433-7398
書誌情報 Brain Tumor Pathology

巻 35, 号 2, p. 106-113, 発行日 2018-04
著者版フラグ
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