{"_buckets": {"deposit": "f5ee024e-21b6-4636-9862-d764bdab5d48"}, "_deposit": {"id": "26319", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "26319"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00026319", "sets": ["2109"]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "298", "bibliographicPageStart": "289", "bibliographicVolumeNumber": "80", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science"}]}]}, "item_9_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Neurodegenerative diseases are disorders that are characterized by a progressive decline of the motor and/or cognitive function caused by a selective loss of neurons within the central nervous system. Recent advancements in the translational research have facilitated extensive insights into the molecular pathophysiology of neurodegenerative diseases. Nonetheless, a myriad of compounds that suppressed the disease progression in cellular and animal models did not exhibit efficacy in clinical trials. Perhaps, various biological, medical, and methodological factors could be attributed to unfavorable results of clinical trials of such disease-modifying therapies. Primarily, the fact that pathological changes at molecular and cellular levels precede the clinical onset by several years underscores a pressing need for the initiation of interventions before the emergence of neurological symptoms. Using exquisite biomarkers, recent studies revealed the preclinical and prodromal progression of pathophysiology, as well as compensatory brain responses in several neurodegenerative diseases. This review aims to discuss the recent advancement of biomarker studies on presymptomatic subjects and the perspective on a preventive trial of disease-modifying therapies for devastating neurological disorders.", "subitem_description_type": "Abstract"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.80.3.289", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University Graduate School of Medicine, School of Medicine"}]}, "item_9_relation_43": {"attribute_name": "異版である", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/803.html ", "subitem_relation_type_select": "URI"}}]}, "item_9_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_61": {"attribute_name": "ISSN（Online）", "attribute_value_mlt": [{"subitem_source_identifier": "2186-3326", "subitem_source_identifier_type": "ISSN"}]}, "item_9_source_id_7": {"attribute_name": "ISSN（print）", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Katsuno, Masahisa"}], "nameIdentifiers": [{"nameIdentifier": "84893", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sahashi, Kentaro"}], "nameIdentifiers": [{"nameIdentifier": "84894", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iguchi, Yohei"}], "nameIdentifiers": [{"nameIdentifier": "84895", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hashizume, Atsushi"}], "nameIdentifiers": [{"nameIdentifier": "84896", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-08-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "01_Katsuno.pdf", "filesize": [{"value": "308.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 308200.0, "url": {"label": "01_Katsuno.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/26319/files/01_Katsuno.pdf"}, "version_id": "690745d6-719e-4da5-9c6e-61437a10982c"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "preclinical", "subitem_subject_scheme": "Other"}, {"subitem_subject": "prodromal", "subitem_subject_scheme": "Other"}, {"subitem_subject": "neurodegenerative disease", "subitem_subject_scheme": "Other"}, {"subitem_subject": "biomarker", "subitem_subject_scheme": "Other"}, {"subitem_subject": "preventive therapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "disease-modifying therapy", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Preclinical progression of neurodegenerative diseases", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Preclinical progression of neurodegenerative diseases"}]}, "item_type_id": "9", "owner": "1", "path": ["2109"], "permalink_uri": "https://doi.org/10.18999/nagjms.80.3.289", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-08-28"}, "publish_date": "2018-08-28", "publish_status": "0", "recid": "26319", "relation": {}, "relation_version_is_last": true, "title": ["Preclinical progression of neurodegenerative diseases"], "weko_shared_id": 3}