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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 80(3)

Comparison of twice a day and three times a day meropenem administration in elderly patients in a Japanese community hospital

https://doi.org/10.18999/nagjms.80.3.391
https://doi.org/10.18999/nagjms.80.3.391
9267aac6-325b-4b26-b91f-1d83c1c52e46
名前 / ファイル ライセンス アクション
11_Aimiya.pdf 11_Aimiya.pdf (326.1 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2018-08-31
タイトル
タイトル Comparison of twice a day and three times a day meropenem administration in elderly patients in a Japanese community hospital
著者 Aimiya, Kouji

× Aimiya, Kouji

WEKO 84949

Aimiya, Kouji

Search repository
Mamiya, Takayoshi

× Mamiya, Takayoshi

WEKO 84950

Mamiya, Takayoshi

Search repository
Tabuchi, Katsunori

× Tabuchi, Katsunori

WEKO 84951

Tabuchi, Katsunori

Search repository
Kita, Toshiyuki

× Kita, Toshiyuki

WEKO 84952

Kita, Toshiyuki

Search repository
Hiramatsu, Masayuki

× Hiramatsu, Masayuki

WEKO 84953

Hiramatsu, Masayuki

Search repository
キーワード
主題Scheme Other
主題 meropenem
キーワード
主題Scheme Other
主題 elderly patient
キーワード
主題Scheme Other
主題 pneumonia
抄録
内容記述 Meropenem (MEPM) is a broad-spectrum antibiotic prescribed to patients with moderate or severe pneumonia. It is well recognized that appropriate medicine reduces the burden on not only young patients but elderly ones as well. We enrolled 56 patients aged 75 and over who were diagnosed with moderate or severe pneumonia (body temperature: ≧37.5 °C; white blood cell (WBC) count: ≧10,000/μL; C-reactive protein (CRP): ≧4 mg/dL) on the basis of Clinical Evaluation Methods for New Antimicrobial Agents to Treat Respiratory Infections defined by the Japanese Society of Chemotherapy, at the National Hospital Organization Kanazawa Medical Center from January 1, 2007 to May 31, 2010. Forty-two patients were given MEPM twice a day and 14 were given the same drug three times a day in a Japanese community hospital. After four days, the three times a day group showed significant decreases in body temperature, WBC count, and CRP level, which are commonly used indices for evaluating therapeutic effects. Similarly, the twice a day group showed decreases of those indices, and both treatments had no serious adverse effects. Simulation analysis based on the pharmacokinetics-pharmacodynamics (PK/PD) theory revealed that both treatments effectively inhibited the activities of Pneumococcus, Haemophilus influenzae, Providencia stuartii, and Staphylococcus aureus, which are the major bacteria in the patients. In this retrospective study, simulation analysis based on the PK/PD theory revealed that even the twice a day MEPM administration has sufficient effectiveness against pneumonia. It also may pave the way for the use of personalized medicine in the patients.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.80.3.391
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/803.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 80, 号 3, p. 391-400, 発行日 2018-08
著者版フラグ
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