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Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study
http://hdl.handle.net/2237/00028550
http://hdl.handle.net/2237/00028550ed25e087-8145-4401-9204-5c7239e889b0
名前 / ファイル | ライセンス | アクション |
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e319d920-d987-41e1-a462-1748be7fc9c8 (2.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-09-10 | |||||
タイトル | ||||||
タイトル | Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study | |||||
言語 | en | |||||
著者 |
Hishida, Asahi
× Hishida, Asahi× Nakatochi, Masahiro× Akiyama, Masato× Kamatani, Yoichiro× Nishiyama, Takeshi× Ito, Hidemi× Oze, Isao× Nishida, Yuichiro× Hara, Megumi× Takashima, Naoyuki× Turin, Tanvir Chowdhury× Watanabe, Miki× Suzuki, Sadao× Ibusuki, Rie× Shimoshikiryo, Ippei× Nakamura, Yohko× Mikami, Haruo× Ikezaki, Hiroaki× Furusyo, Norihiro× Kuriki, Kiyonori× Endoh, Kaori× Koyama, Teruhide× Matsui, Daisuke× Uemura, Hirokazu× Arisawa, Kokichi× Sasakabe, Tae× Okada, Rieko× Kawai, Sayo× Naito, Mariko× Momozawa, Yukihide× Kubo, Michiaki× Wakai, Kenji |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is the accepted manuscript version of an article published by S. Karger AG in [American Journal of Nephrology/2018/47/5/304-316 DOI:10.1159/000488946] including DOI and available on https://doi.org/10.1159/000488946. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chronic kidney disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Genome-wide association study | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Population-based cohort | |||||
抄録 | ||||||
内容記述 | Background: Chronic kidney disease (CKD) is a rapidly growing, worldwide public health problem. Recent advances in genome-wide-association studies (GWAS) revealed several genetic loci associated with renal function traits worldwide. Methods: We investigated the association of genetic factors with the levels of serum creatinine (SCr) and the estimated glomerular filtration rate (eGFR) in Japanese population-based cohorts analyzing the GWAS imputed data with 11,221 subjects and 12,617,569 variants, and replicated the findings with the 148,829 hospital-based Japanese subjects. Results: In the discovery phase, 28 variants within 4 loci (chromosome [chr] 2 with 8 variants including rs3770636 in the LDL receptor related protein 2 gene locus, on chr 5 with 2 variants including rs270184, chr 17 with 15 variants including rs3785837 in the BCAS3 gene locus, and chr 18 with 3 variants including rs74183647 in the nuclear factor of activated T-cells 1 gene locus) reached the suggestive level of p < 1 × 10^–6 in association with eGFR and SCr, and 2 variants on chr 4 (including rs78351985 in the microsomal triglyceride transfer protein gene locus) fulfilled the suggestive level in association with the risk of CKD. In the replication phase, 25 variants within 3 loci (chr 2 with 7 variants, chr 17 with 15 variants and chr 18 with 3 variants) in association with eGFR and SCr, and 2 variants on chr 4 associated with the risk of CKD became nominally statistically significant after Bonferroni correction, among which 15 variants on chr 17 and 3 variants on chr 18 reached genome-wide significance of p < 5 × 10^–8 in the combined study meta-analysis. The associations of the loci on chr 2 and 18 with eGFR and SCr as well as that on chr 4 with CKD risk have not been previously reported in the Japanese and East Asian populations. Conclusion: Although the present GWAS of renal function traits included the largest sample of Japanese participants to date, we did not identify novel loci for renal traits. However, we identified the novel associations of the genetic loci on chr 2, 4, and 18 with renal function traits in the Japanese population, suggesting these are transethnic loci. Further investigations of these associations are expected to further validate our findings for the potential establishment of personalized prevention of renal disease in the Japanese and East Asian populations. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | ファイル公開:2019/06/01 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Karger | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1159/000488946 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0250-8095 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 1421-9670 | |||||
書誌情報 |
en : American Journal of Nephrology 巻 47, 号 5, p. 304-316, 発行日 2018-06 |
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著者版フラグ | ||||||
値 | author |