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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study

http://hdl.handle.net/2237/00028550
http://hdl.handle.net/2237/00028550
ed25e087-8145-4401-9204-5c7239e889b0
名前 / ファイル ライセンス アクション
e319d920-d987-41e1-a462-1748be7fc9c8.pdf e319d920-d987-41e1-a462-1748be7fc9c8 (2.4 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-09-10
タイトル
タイトル Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study
言語 en
著者 Hishida, Asahi

× Hishida, Asahi

WEKO 85167

en Hishida, Asahi

Search repository
Nakatochi, Masahiro

× Nakatochi, Masahiro

WEKO 85168

en Nakatochi, Masahiro

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Akiyama, Masato

× Akiyama, Masato

WEKO 85169

en Akiyama, Masato

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Kamatani, Yoichiro

× Kamatani, Yoichiro

WEKO 85170

en Kamatani, Yoichiro

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Nishiyama, Takeshi

× Nishiyama, Takeshi

WEKO 85171

en Nishiyama, Takeshi

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Ito, Hidemi

× Ito, Hidemi

WEKO 85172

en Ito, Hidemi

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Oze, Isao

× Oze, Isao

WEKO 85173

en Oze, Isao

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Nishida, Yuichiro

× Nishida, Yuichiro

WEKO 85174

en Nishida, Yuichiro

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Hara, Megumi

× Hara, Megumi

WEKO 85175

en Hara, Megumi

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Takashima, Naoyuki

× Takashima, Naoyuki

WEKO 85176

en Takashima, Naoyuki

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Turin, Tanvir Chowdhury

× Turin, Tanvir Chowdhury

WEKO 85177

en Turin, Tanvir Chowdhury

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Watanabe, Miki

× Watanabe, Miki

WEKO 85178

en Watanabe, Miki

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Suzuki, Sadao

× Suzuki, Sadao

WEKO 85179

en Suzuki, Sadao

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Ibusuki, Rie

× Ibusuki, Rie

WEKO 85180

en Ibusuki, Rie

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Shimoshikiryo, Ippei

× Shimoshikiryo, Ippei

WEKO 85181

en Shimoshikiryo, Ippei

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Nakamura, Yohko

× Nakamura, Yohko

WEKO 85182

en Nakamura, Yohko

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Mikami, Haruo

× Mikami, Haruo

WEKO 85183

en Mikami, Haruo

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Ikezaki, Hiroaki

× Ikezaki, Hiroaki

WEKO 85184

en Ikezaki, Hiroaki

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Furusyo, Norihiro

× Furusyo, Norihiro

WEKO 85185

en Furusyo, Norihiro

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Kuriki, Kiyonori

× Kuriki, Kiyonori

WEKO 85186

en Kuriki, Kiyonori

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Endoh, Kaori

× Endoh, Kaori

WEKO 85187

en Endoh, Kaori

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Koyama, Teruhide

× Koyama, Teruhide

WEKO 85188

en Koyama, Teruhide

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Matsui, Daisuke

× Matsui, Daisuke

WEKO 85189

en Matsui, Daisuke

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Uemura, Hirokazu

× Uemura, Hirokazu

WEKO 85190

en Uemura, Hirokazu

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Arisawa, Kokichi

× Arisawa, Kokichi

WEKO 85191

en Arisawa, Kokichi

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Sasakabe, Tae

× Sasakabe, Tae

WEKO 85192

en Sasakabe, Tae

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Okada, Rieko

× Okada, Rieko

WEKO 85193

en Okada, Rieko

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Kawai, Sayo

× Kawai, Sayo

WEKO 85194

en Kawai, Sayo

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Naito, Mariko

× Naito, Mariko

WEKO 85195

en Naito, Mariko

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Momozawa, Yukihide

× Momozawa, Yukihide

WEKO 85196

en Momozawa, Yukihide

Search repository
Kubo, Michiaki

× Kubo, Michiaki

WEKO 85197

en Kubo, Michiaki

Search repository
Wakai, Kenji

× Wakai, Kenji

WEKO 85198

en Wakai, Kenji

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the accepted manuscript version of an article published by S. Karger AG in [American Journal of Nephrology/2018/47/5/304-316 DOI:10.1159/000488946] including DOI and available on https://doi.org/10.1159/000488946.
キーワード
主題Scheme Other
主題 Chronic kidney disease
キーワード
主題Scheme Other
主題 Genome-wide association study
キーワード
主題Scheme Other
主題 Population-based cohort
抄録
内容記述 Background: Chronic kidney disease (CKD) is a rapidly growing, worldwide public health problem. Recent advances in genome-wide-association studies (GWAS) revealed several genetic loci associated with renal function traits worldwide. Methods: We investigated the association of genetic factors with the levels of serum creatinine (SCr) and the estimated glomerular filtration rate (eGFR) in Japanese population-based cohorts analyzing the GWAS imputed data with 11,221 subjects and 12,617,569 variants, and replicated the findings with the 148,829 hospital-based Japanese subjects. Results: In the discovery phase, 28 variants within 4 loci (chromosome [chr] 2 with 8 variants including rs3770636 in the LDL receptor related protein 2 gene locus, on chr 5 with 2 variants including rs270184, chr 17 with 15 variants including rs3785837 in the BCAS3 gene locus, and chr 18 with 3 variants including rs74183647 in the nuclear factor of ­activated T-cells 1 gene locus) reached the suggestive level of p < 1 × 10^–6 in association with eGFR and SCr, and 2 variants on chr 4 (including rs78351985 in the microsomal triglyceride transfer protein gene locus) fulfilled the suggestive level in association with the risk of CKD. In the replication phase, 25 variants within 3 loci (chr 2 with 7 variants, chr 17 with 15 variants and chr 18 with 3 variants) in association with eGFR and SCr, and 2 variants on chr 4 associated with the risk of CKD became nominally statistically significant after Bonferroni correction, among which 15 variants on chr 17 and 3 variants on chr 18 reached genome-wide significance of p < 5 × 10^–8 in the combined study meta-analysis. The associations of the loci on chr 2 and 18 with eGFR and SCr as well as that on chr 4 with CKD risk have not been previously reported in the Japanese and East Asian populations. Conclusion: Although the present GWAS of renal function traits included the largest sample of Japanese participants to date, we did not identify novel loci for renal traits. However, we identified the novel associations of the genetic loci on chr 2, 4, and 18 with renal function traits in the Japanese population, suggesting these are transethnic loci. Further investigations of these associations are expected to further validate our findings for the potential establishment of personalized prevention of renal disease in the Japanese and East Asian populations.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2019/06/01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Karger
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1159/000488946
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0250-8095
ISSN(Online)
収録物識別子タイプ EISSN
収録物識別子 1421-9670
書誌情報 en : American Journal of Nephrology

巻 47, 号 5, p. 304-316, 発行日 2018-06
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