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  1. F100 環境医学研究所
  2. F100a 雑誌掲載論文
  3. 学術雑誌

Role of GABA in the regulation of the central circadian clock of the suprachiasmatic nucleus

http://hdl.handle.net/2237/00028553
http://hdl.handle.net/2237/00028553
fed70ad9-8707-419e-9f2a-4d1ad29b5cd8
名前 / ファイル ライセンス アクション
Neurosci_Res_GABA_20171109.pdf Neurosci_Res_GABA_20171109 (637.3 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-09-11
タイトル
タイトル Role of GABA in the regulation of the central circadian clock of the suprachiasmatic nucleus
言語 en
著者 Ono, Daisuke

× Ono, Daisuke

WEKO 85202

en Ono, Daisuke

Search repository
Honma, Ken-ichi

× Honma, Ken-ichi

WEKO 85203

en Honma, Ken-ichi

Search repository
Yanagawa, Yuchio

× Yanagawa, Yuchio

WEKO 85204

en Yanagawa, Yuchio

Search repository
Yamanaka, Akihiro

× Yamanaka, Akihiro

WEKO 85205

en Yamanaka, Akihiro

Search repository
Honma, Sato

× Honma, Sato

WEKO 85206

en Honma, Sato

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 “This is a post-peer-review, pre-copyedit version of an article published in [The Journal of Physiological Sciences]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12576-018-0604-x”.
キーワード
主題Scheme Other
主題 Circadian rhythm
キーワード
主題Scheme Other
主題 Suprachiasmatic nucleus
キーワード
主題Scheme Other
主題 Clock gene
キーワード
主題Scheme Other
主題 Cellular networks
キーワード
主題Scheme Other
主題 GABA
キーワード
主題Scheme Other
主題 Photoperiod
抄録
内容記述 In mammals, circadian rhythms, such as sleep/wake cycles, are regulated by the central circadian clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus. The SCN consists of thousands of individual neurons, which exhibit circadian rhythms. They synchronize with each other and produce robust and stable oscillations. Although several neurotransmitters are expressed in the SCN, almost all SCN neurons are γ-amino butyric acid (GABA)-ergic. Several studies have attempted to understand the roles of GABA in the SCN; however, precise mechanisms of the action of GABA in the SCN are still unclear. GABA exhibits excitatory and/or inhibitory characteristics depending on the circadian phase or region in the SCN. It can both synchronize and destabilize cellular circadian rhythms in individual SCN cells. Differing environmental light conditions, such as a long photoperiod, result in the decoupling of circadian oscillators of the dorsal and ventral SCN. This is due to high intracellular chloride concentrations in the dorsal SCN. Because mice with functional GABA deficiency, such as vesicular GABA transporter- and glutamate decarboxylase-deficient mice, are neonatal lethal, research has been limited to pharmacological approaches. Furthermore, different recording methods have been used to understand the roles of GABA in the SCN. The excitability of GABAergic neurons also changes during the postnatal period. Although there are technical difficulties in understanding the functions of GABA in the SCN, technical developments may help uncover new roles of GABA in circadian physiology and behavior.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2019/07/01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s12576-018-0604-x
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 1880-6546
ISSN(Online)
収録物識別子タイプ EISSN
収録物識別子 1880-6562
書誌情報 en : The Journal of Physiological Sciences

巻 68, 号 4, p. 333-343, 発行日 2018-07
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