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Increased expression level of Hsp70 in the inner ears of mice by exposure to low frequency noise
http://hdl.handle.net/2237/00028563
http://hdl.handle.net/2237/00028563fbcab236-1f52-4efd-9d87-cd17276b15bb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Ninomiya180301 (915.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-09-11 | |||||
| タイトル | ||||||
| タイトル | Increased expression level of Hsp70 in the inner ears of mice by exposure to low frequency noise | |||||
| 言語 | en | |||||
| 著者 |
Ninomiya, Hiromasa
× Ninomiya, Hiromasa× Ohgami, Nobutaka× Oshino, Reina× Kato, Masashi× Ohgami, Kyoko× Li, Xiang× Shen, Dandan× Iida, Machiko× Yajima, Ichiro× Angelidis, Charalampos E.× Adachi, Hiroaki× Katsuno, Masahisa× Sobue, Gen× Kato, Masashi |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Low frequency noise | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Inner ear | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Heat shock protein 70 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cebpβ | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Vestibule | |||||
| 抄録 | ||||||
| 内容記述 | Previous studies showed that people in urban areas are possibly exposed to 60–110 dB of low frequency noise (LFN) defined as noise of ≤100 Hz in their daily life. Previous studies also showed increased health risks by exposure to high levels (130–140 dB) of LFN in animals. However, little is known about the health effects of exposure to an ordinary level of LFN. We biochemically and immunohistochemically assessed the effects of exposure to inaudible LFN for mice (12 h/day of 100 Hz LFN at 95 dB for 5 days), at a level to which people are possibly exposed in daily life, on a murine inner ear by targeting 9 stress-reactive molecules. There was more than a 5-fold increased transcript level of heat shock protein 70 (Hsp70) in the whole inner ear exposed to LFN. However, the transcript levels of the other 8 stress-reactive molecules including Hsp27 and Hsp90 were comparable in LFN-exposed and unexposed murine inner ears. Only the transcript level of Cebpβ among the previously reported 4 transcriptional activators for Hsp70 expression was more than 3-fold increased by LFN exposure. Hsp70 transcript expression levels in the inner ears 3 days after LFN exposure were comparable to those in unexposed inner ears. The protein level of Hsp70, but not the levels of Hsp27 and Hsp90, was also increased in the vestibule by LFN exposure. However, hearing levels as well as expression levels of Hsp70 protein in the cochleae were comparable in LFN-exposed mice and unexposed mice. Our results demonstrated that the inner ear might be one of the organs that is negatively affected by stress from inaudible LFN exposure. Moreover, LFN exposure might increase Hsp70 expression level via Cebpβ in the inner ear. Thus, Hsp70 and Cebpβ levels could be candidates of biomarkers for response to LFN exposure. | |||||
| 言語 | en | |||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | ||||||
| 内容記述 | ファイル公開：2019-06-01 | |||||
| 言語 | ja | |||||
| 内容記述タイプ | Other | |||||
| 出版者 | ||||||
| 言語 | en | |||||
| 出版者 | Elsevier | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.heares.2018.02.006 | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0378-5955 | |||||
| 書誌情報 |
en : Hearing Research 巻 363, p. 49-54, 発行日 2018-06 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
