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Congenic mapping and candidate gene analysis for streptozotocin-induced diabetes susceptibility locus on mouse chromosome 11
http://hdl.handle.net/2237/00028565
http://hdl.handle.net/2237/000285658085ee2c-5e0c-43a7-ba48-1506baf9eeec
名前 / ファイル | ライセンス | アクション |
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Ohno_T_Stzds1 (383.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-09-11 | |||||
タイトル | ||||||
タイトル | Congenic mapping and candidate gene analysis for streptozotocin-induced diabetes susceptibility locus on mouse chromosome 11 | |||||
言語 | en | |||||
著者 |
Maegawa, Tomoki
× Maegawa, Tomoki× Miyasaka, Yuki× Kobayashi, Misato× Babaya, Naru× Ikegami, Hiroshi× Horio, Fumihiko× Takahashi, Masahide× Ohno, Tamio |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | “This is a post-peer-review, pre-copyedit version of an article published in [Mammalian Genome]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00335-018-9742-y”. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | A/J mice | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | congenic mapping | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | consomic strain | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | N-methylpurine DNA glycosylase gene | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | streptozotocin-induced diabetes susceptibility locus | |||||
抄録 | ||||||
内容記述 | Streptozotocin (STZ) has been widely used to induce diabetes in rodents. Strain-dependent variation in susceptibility to STZ has been reported; however, the gene(s) responsible for STZ susceptibility has not been identified. Here, we utilized the A/J-11SM consomic strain and a set of chromosome 11 (Chr. 11) congenic strains developed from A/J-11SM to identify a candidate STZ-induced diabetes susceptibility gene. The A/J strain exhibited significantly higher susceptibility to STZ-induced diabetes than the A/J-11SM strain, confirming the existence of a susceptibility locus on Chr. 11. We named this locus Stzds1 (STZ-induced diabetes susceptibility 1). Congenic mapping using the Chr. 11 congenic strains indicated that the Stzds1 locus was located between D11Mit163 (27.72 Mb) and D11Mit51 (36.39 Mb). The Mpg gene, which encodes N-methylpurine DNA glycosylase (MPG), a ubiquitous DNA repair enzyme responsible for the removal of alkylated base lesions in DNA, is located within the Stzds1 region. There is a close relationship between DNA alkylation at an early stage of STZ action and the function of MPG. A Sanger sequence analysis of the Mpg gene revealed five polymorphic sites in the A/J genome. One variant, p.Ala132Ser, was located in a highly conserved region among rodent species and in the minimal region for retained enzyme activity of MPG. It is likely that structural alteration of MPG caused by the p.Ala132Ser mutation elicits increased recognition and excision of alkylated base lesions in DNA by STZ. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | ファイル公開:2019/04/01 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Springer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s00335-018-9742-y | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0938-8990 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 1432-1777 | |||||
書誌情報 |
en : Mammalian Genome 巻 29, 号 3-4, p. 273-280, 発行日 2018-04 |
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著者版フラグ | ||||||
値 | author |