{"_buckets": {"deposit": "b5e047b4-5b22-499b-a182-8b8ef122b48d"}, "_deposit": {"id": "26370", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "26370"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00026370", "sets": ["501"]}, "author_link": ["85290", "85291", "85292", "85293", "85294", "85295", "85296", "85297", "85298"], "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-03", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "179", "bibliographicPageStart": "167", "bibliographicVolumeNumber": "69", "bibliographic_titles": [{"bibliographic_title": "Brain, Behavior, and Immunity", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Stress is associated with pathophysiology of both irritable bowel syndrome (IBS) and hypertension. Angiotensin receptor blockers (ARB) have anti-inflammatory properties via inhibition of angiotensin II (Ang II)/Ang II type I receptor axis (AT1). Inhibition of the classical RAS pathway is also involved in upregulation of angiotensin converting enzyme-2 (ACE2), which activates the Ang-(1–7)/Mas pathway to counteract inflammatory signaling and acts as a partner of the amino acid transporter, B^0AT-1, to absorb tryptophan for regulation of microbiota-gut-brain axis. In this study, we determined the effects of ARB irbesartan on stress-induced intestinal inflammation. C57BL/6J mice were subjected to 2-week intermittent restraint stress. They were orally treated during the stress with either vehicle, 3 or 10 mg/kg/day irbesartan. Restraint stress resulted in colon inflammation with higher histological damage scores, increased expression of Nox4, TLR-4 and IL1-β, accumulation of reactive oxygen species (ROS), and activation of the ACE–angiotensin II–AT1 receptor axis. Stress also downregulated intestinal amino acid transporter, ACE2/B^0AT-1, and activity of intestinal mammalian target of rapamycin (mTOR) and p70 S6 kinase (p70S6K), resulting in decrease in α-defensins, changes in intestinal microbial contents, and perturbation of tryptophan metabolism with activation of the kynurenine pathway. Administration of irbesartan inhibited activation of stress-induced AT1 pathway to reduce intestinal ROS accumulation and inflammation, restored expression of ACE2/B^0AT-1, activity of mTOR and p70S6K, dysbiosis and tryptophan metabolism. Our results suggest that AT1 is a potentially suitable therapeutic target in stress-induced intestinal inflammation, and that irbesartan could be beneficially suitable for the treatment of stressed patients with IBS.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "ファイル公開：2019-03-01 ", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.bbi.2017.11.010", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/", "subitem_rights_language": "en"}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN（print）", "attribute_value_mlt": [{"subitem_source_identifier": "0889-1591", "subitem_source_identifier_type": "PISSN"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yisireyili, Maimaiti", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "85290", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Uchida, Yasuhiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "85291", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamamoto, Koji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "85292", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakayama, Takayuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "85293", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Cheng, Xian Wu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "85294", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsushita, Tadashi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "85295", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Shigeo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "85296", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murohara, Toyoaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "85297", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takeshita, Kyosuke", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "85298", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-03-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "BBI-D-17-00406R1.pdf", "filesize": [{"value": "1.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 1500000.0, "url": {"label": "BBI-D-17-00406R1", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/26370/files/BBI-D-17-00406R1.pdf"}, "version_id": "f13269b0-8ab6-4201-9d60-11e567ea7662"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Stress", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Intestinal inflammation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Micro-biota", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Renin-angiotensinogen system", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Reactive oxygen species", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Tryptophan metabolism", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Angiotensin receptor blocker irbesartan reduces stress-induced intestinal inflammation via AT1a signaling and ACE2-dependent mechanism in mice", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Angiotensin receptor blocker irbesartan reduces stress-induced intestinal inflammation via AT1a signaling and ACE2-dependent mechanism in mice", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["501"], "permalink_uri": "http://hdl.handle.net/2237/00028573", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2018-09-12"}, "publish_date": "2018-09-12", "publish_status": "0", "recid": "26370", "relation": {}, "relation_version_is_last": true, "title": ["Angiotensin receptor blocker irbesartan reduces stress-induced intestinal inflammation via AT1a signaling and ACE2-dependent mechanism in mice"], "weko_shared_id": -1}