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High isolation rate and multidrug resistance tendency of penicillin-susceptible group B Streptococcus with reduced ceftibuten susceptibility in Japan
http://hdl.handle.net/2237/00028608
http://hdl.handle.net/2237/000286080407c0e1-952a-4625-916f-901e0ac043c2
名前 / ファイル | ライセンス | アクション |
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EJCM-Banno_et_al_2018 (1.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-10-09 | |||||
タイトル | ||||||
タイトル | High isolation rate and multidrug resistance tendency of penicillin-susceptible group B Streptococcus with reduced ceftibuten susceptibility in Japan | |||||
言語 | en | |||||
著者 |
Banno, Hirotsugu
× Banno, Hirotsugu× Kimura, Kouji× Seki, Tomomi× Jin, Wanchun× Wachino, Jun-ichi× Yamada, Keiko× Nagano, Noriyuki× Arakawa, Yoshichika |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | “This is a post-peer-review, pre-copyedit version of an article published in [European Journal of Clinical Microbiology & Infectious Diseases]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10096-018-3278-7”. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Group B Streptococcus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Reduced ceftibuten susceptibility | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Penicillin-binding protein 2X | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Multidrug resistance | |||||
抄録 | ||||||
内容記述 | Group B Streptococcus (GBS) clinical isolates with reduced penicillin susceptibility (PRGBS) have emerged through acquisition of amino acid substitutions in penicillin-binding protein 2X (PBP2X). Moreover, we also reported the emergence of penicillin-susceptible GBS clinical isolates with reduced ceftibuten susceptibility (CTB^r PSGBS) due to amino acid substitutions in PBPs. However, whether or not these amino acid substitutions are responsible for the reduced ceftibuten susceptibility (RCTBS) profile remains unclear. Furthermore, the rate of CTB^r PSGBS isolation and their multidrug resistance tendency remain uncertain. Therefore, we collected 377 clinical GBS isolates from multiple regions in Japan between August 2013 and August 2015. These isolates were characterized by determining MICs and sequencing the pbp2x gene. The isolation rate of CTB^r PSGBS was 7.2% (27/377). CTBr PSGBS isolate harbor two types of amino acid substitutions in PBP2X [(T394A type) and (I377V, G398A, Q412L, and H438H type)]. The relevance of the amino acid substitutions found to the RCTBS was confirmed with allelic exchange techniques. Allelic exchange recombinant clones acquired two types of amino acid substitutions in PBP2X showed RCTBS. Furthermore, total ratio of resistance and non-susceptibility to both macrolides and fluoroquinolones in CTB^r PSGBS was 51.9% (14/27). The isolation rate of CTB^r PSGBS is non-negligibly high and the CTB^r PSGBS tends to exhibit resistance and non-susceptible profile to both macrolides and fluoroquinolones. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | ファイル公開:2019/08/01 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Elsevier | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s10096-018-3278-7 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0934-9723 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 1435-4373 | |||||
書誌情報 |
en : European Journal of Clinical Microbiology & Infectious Diseases 巻 37, 号 8, p. 1511-1519, 発行日 2018-08-01 |
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著者版フラグ | ||||||
値 | author |