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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

High isolation rate and multidrug resistance tendency of penicillin-susceptible group B Streptococcus with reduced ceftibuten susceptibility in Japan

http://hdl.handle.net/2237/00028608
0407c0e1-952a-4625-916f-901e0ac043c2
名前 / ファイル ライセンス アクション
EJCM-Banno_et_al_2018.pdf EJCM-Banno_et_al_2018 (1.7 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-10-09
タイトル
タイトル High isolation rate and multidrug resistance tendency of penicillin-susceptible group B Streptococcus with reduced ceftibuten susceptibility in Japan
著者 Banno, Hirotsugu

× Banno, Hirotsugu

WEKO 86765

Banno, Hirotsugu

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Kimura, Kouji

× Kimura, Kouji

WEKO 86766

Kimura, Kouji

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Seki, Tomomi

× Seki, Tomomi

WEKO 86767

Seki, Tomomi

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Jin, Wanchun

× Jin, Wanchun

WEKO 86768

Jin, Wanchun

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Wachino, Jun-ichi

× Wachino, Jun-ichi

WEKO 86769

Wachino, Jun-ichi

Search repository
Yamada, Keiko

× Yamada, Keiko

WEKO 86770

Yamada, Keiko

Search repository
Nagano, Noriyuki

× Nagano, Noriyuki

WEKO 86771

Nagano, Noriyuki

Search repository
Arakawa, Yoshichika

× Arakawa, Yoshichika

WEKO 86772

Arakawa, Yoshichika

Search repository
権利
権利情報 “This is a post-peer-review, pre-copyedit version of an article published in [European Journal of Clinical Microbiology & Infectious Diseases]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10096-018-3278-7”.
キーワード
主題Scheme Other
主題 Group B Streptococcus
キーワード
主題Scheme Other
主題 Reduced ceftibuten susceptibility
キーワード
主題Scheme Other
主題 Penicillin-binding protein 2X
キーワード
主題Scheme Other
主題 Multidrug resistance
抄録
内容記述 Group B Streptococcus (GBS) clinical isolates with reduced penicillin susceptibility (PRGBS) have emerged through acquisition of amino acid substitutions in penicillin-binding protein 2X (PBP2X). Moreover, we also reported the emergence of penicillin-susceptible GBS clinical isolates with reduced ceftibuten susceptibility (CTB^r PSGBS) due to amino acid substitutions in PBPs. However, whether or not these amino acid substitutions are responsible for the reduced ceftibuten susceptibility (RCTBS) profile remains unclear. Furthermore, the rate of CTB^r PSGBS isolation and their multidrug resistance tendency remain uncertain. Therefore, we collected 377 clinical GBS isolates from multiple regions in Japan between August 2013 and August 2015. These isolates were characterized by determining MICs and sequencing the pbp2x gene. The isolation rate of CTB^r PSGBS was 7.2% (27/377). CTBr PSGBS isolate harbor two types of amino acid substitutions in PBP2X [(T394A type) and (I377V, G398A, Q412L, and H438H type)]. The relevance of the amino acid substitutions found to the RCTBS was confirmed with allelic exchange techniques. Allelic exchange recombinant clones acquired two types of amino acid substitutions in PBP2X showed RCTBS. Furthermore, total ratio of resistance and non-susceptibility to both macrolides and fluoroquinolones in CTB^r PSGBS was 51.9% (14/27). The isolation rate of CTB^r PSGBS is non-negligibly high and the CTB^r PSGBS tends to exhibit resistance and non-susceptible profile to both macrolides and fluoroquinolones.
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2019/08/01
内容記述タイプ Other
出版者
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s10096-018-3278-7
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0934-9723
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 1435-4373
書誌情報 European Journal of Clinical Microbiology & Infectious Diseases

巻 37, 号 8, p. 1511-1519, 発行日 2018-08-01
著者版フラグ
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