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An autopsy case report : Differences in radiological images correlate with histology in Erdheim-Chester disease
http://hdl.handle.net/2237/00028623
http://hdl.handle.net/2237/000286238e38ba75-5bc4-4930-8c52-16b84d4e9fbd
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Pathology_international_Ohara (1.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-10-11 | |||||
| タイトル | ||||||
| タイトル | An autopsy case report : Differences in radiological images correlate with histology in Erdheim-Chester disease | |||||
| 言語 | en | |||||
| 著者 |
Ohara, Yuuki
× Ohara, Yuuki× Kato, Seiichi× Yamashita, Daisuke× Satou, Akira× Shimoyama, Yoshie× Hamaie, Chie× Sato, Motoki× Ban, Nobutaro× Yamamoto, Koji× Yamada, Takehiro× Kawai, Hisashi× Ohshima, Koichi× Nakamura, Shigeo× Toyokuni, Shinya |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | This is the peer reviewed version of the following article: [Ohara, Y. , Kato, S. , Yamashita, D. , Satou, A. , Shimoyama, Y. , Hamaie, C. , Sato, M. , Ban, N. , Yamamoto, K. , Yamada, T. , Kawai, H. , Ohshima, K. , Nakamura, S. and Toyokuni, S. (2018), An autopsy case report: Differences in radiological images correlate with histology in Erdheim–Chester disease. Pathol Int, 68: 374-381. doi:10.1111/pin.12663], which has been published in final form at [https://doi.org/10.1111/pin.12663]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | autopsy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | bone scintigraphy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Erdheim–Chester disease | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hexokinase II | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | non‐Langerhans cell histiocytosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | oncogene‐induced senescence | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | radio‐histological correlation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 18F‐fluorodeoxyglucose‐positron emission tomography/computed tomography | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | p16 activation caused by oncogenic mutations may represent oncogene‐induced senescence (OIS), a protective mechanism against oncogenic events. However, OIS can contribute to tumor development via tissue remodeling in some tumors. Erdheim–Chester disease (ECD), a rare non‐Langerhans cell histiocytosis, is one such tumor. Its clinical and histological features vary, making it difficult to diagnose. Herein, we describe an autopsy of an ECD patient. The patient underwent radiological examinations, including 18F‐fluorodeoxyglucose (FDG)‐positron emission tomography/computed tomography (PET/CT), bone scintigraphy and CT. A biopsy from the lesion with the highest FDG accumulation confirmed the presence of foamy macrophages, a diagnostic clue for ECD. Based on this finding and the clinical features, ECD was diagnosed. However, the patient died from heart dysfunction. After the autopsy, each radiologically different site showed various histological findings regarding the morphology of macrophages, fibrosis, inflammation, and p16 expression. OIS‐induced histological progression can cause certain changes observed in radiological images. In addition, in order to evaluate the increase in glucose metabolism, which can affect FDG accumulation, the expression of glucose transporter 1 and hexokinase II was also analyzed. Summarizing the radio‐histological correlation can help further both the understanding and diagnosis of ECD. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ファイル公開：2019-06-04 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Wiley | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1111/pin.12663 | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1320-5463 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 1440-1827 | |||||
| 書誌情報 |
en : Pathology International 巻 68, 号 6, p. 374-381, 発行日 2018-06-04 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
