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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases

http://hdl.handle.net/2237/00028624
http://hdl.handle.net/2237/00028624
c1d2e16d-6bc0-434a-85b5-af6f617b60d7
名前 / ファイル ライセンス アクション
manuscript.pdf manuscript (198.0 kB)
Revised_figure.pdf Revised_figure (208.2 MB)
Revised_supplemental_figure.pdf Revised_supplemental_figure (71.7 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-10-12
タイトル
タイトル The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases
言語 en
著者 Mori, Yoshiko

× Mori, Yoshiko

WEKO 86908

en Mori, Yoshiko

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Masuda, Tomohiro

× Masuda, Tomohiro

WEKO 86909

en Masuda, Tomohiro

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Kosugi, Tomoki

× Kosugi, Tomoki

WEKO 86910

en Kosugi, Tomoki

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Yoshioka, Tomoki

× Yoshioka, Tomoki

WEKO 86911

en Yoshioka, Tomoki

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Hori, Mayuko

× Hori, Mayuko

WEKO 86912

en Hori, Mayuko

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Nagaya, Hiroshi

× Nagaya, Hiroshi

WEKO 86913

en Nagaya, Hiroshi

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Maeda, Kayaho

× Maeda, Kayaho

WEKO 86914

en Maeda, Kayaho

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Sato, Yuka

× Sato, Yuka

WEKO 86915

en Sato, Yuka

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Kojima, Hiroshi

× Kojima, Hiroshi

WEKO 86916

en Kojima, Hiroshi

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Kato, Noritoshi

× Kato, Noritoshi

WEKO 86917

en Kato, Noritoshi

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Ishimoto, Takuji

× Ishimoto, Takuji

WEKO 86918

en Ishimoto, Takuji

Search repository
Katsuno, Takayuki

× Katsuno, Takayuki

WEKO 86919

en Katsuno, Takayuki

Search repository
Yuzawa, Yukio

× Yuzawa, Yukio

WEKO 86920

en Yuzawa, Yukio

Search repository
Kadomatsu, Kenji

× Kadomatsu, Kenji

WEKO 86921

en Kadomatsu, Kenji

Search repository
Maruyama, Shoichi

× Maruyama, Shoichi

WEKO 86922

en Maruyama, Shoichi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 “This is a post-peer-review, pre-copyedit version of an article published in [Clinical and Experimental Nephrology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10157-017-1518-2”.
キーワード
主題Scheme Other
主題 CD147
キーワード
主題Scheme Other
主題 Inflammation
キーワード
主題Scheme Other
主題 Proteinuria
抄録
内容記述 Background: Precise understanding of kidney disease activity is needed to design therapeutic strategies. CD147/basigin is involved in the pathogenesis of acute kidney injury and renal fibrosis through inflammatory cell infiltration. The present study examined the clinical relevance of CD147 in biopsy-proven kidney diseases that lead to the progression of chronic kidney disease. Methods: Kidney biopsy specimens and plasma and urine samples were obtained from patients with kidney diseases, including IgA nephropathy (IgAN), Henoch–Schönlein purpura nephritis (HSPN), diabetic kidney disease (DKD), focal segmental glomerulosclerosis (FSGS), and membranous nephropathy (MN), who underwent renal biopsy between 2011 and 2014. Plasma and urinary CD147 levels were measured and evaluated for their ability to reflect histological features. Disease activity of IgAN tissues was evaluated according to the Oxford classification and the Japanese histological grading system. Results: In biopsy tissues, CD147 induction was detected in injured lesions representing renal inflammation. Plasma CD147 values correlated with eGFR in patients with inflammation-related kidney diseases such as IgAN, HSPN, and DKD. Particularly in IgAN patients, plasma CD147 levels were correlated with injured regions comprising more than 50% of glomeruli or with tubular atrophy/interstitial injury in biopsy tissues. Proteinuria showed a closer correlation with urinary values of CD147 and L-FABP. Of note, plasma and urinary CD147 levels showed a strong correlation with eGFR or proteinuria, respectively, only in DKD patients. Conclusion: Evaluation of plasma and urinary CD147 levels might provide key insights for the understanding of the activity of various kidney diseases.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2019/08/01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s10157-017-1518-2
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 1342-1751
ISSN(Online)
収録物識別子タイプ EISSN
収録物識別子 1437-7799
書誌情報 en : Clinical and Experimental Nephrology

巻 22, 号 4, p. 815-824, 発行日 2018-08
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