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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Differentiating cells mechanically limit the interkinetic nuclear migration of progenitor cells to secure apical cytogenesis

http://hdl.handle.net/2237/00028794
http://hdl.handle.net/2237/00028794
6c2ddc92-e72a-44c5-af64-8feee64df1b1
名前 / ファイル ライセンス アクション
dev162883full.pdf dev162883full (9.6 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-11-13
タイトル
タイトル Differentiating cells mechanically limit the interkinetic nuclear migration of progenitor cells to secure apical cytogenesis
言語 en
著者 Watanabe, Yuto

× Watanabe, Yuto

WEKO 87917

en Watanabe, Yuto

Search repository
Kawaue, Takumi

× Kawaue, Takumi

WEKO 87918

en Kawaue, Takumi

Search repository
Miyata, Takaki

× Miyata, Takaki

WEKO 87919

en Miyata, Takaki

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2018. Published by The Company of Biologists Ltd
キーワード
主題Scheme Other
主題 Interkinetic nuclear migration
キーワード
主題Scheme Other
主題 Radial glia
キーワード
主題Scheme Other
主題 Ventricular zone
キーワード
主題Scheme Other
主題 Pseudostratified epithelium
キーワード
主題Scheme Other
主題 Neocortex
キーワード
主題Scheme Other
主題 Mouse
抄録
内容記述 Many proliferative epithelia are pseudostratified because of cell cycle-dependent interkinetic nuclear migration (IKNM, basal during G1 and apical during G2). Although most epithelia, including early embryonic neuroepithelia (≤100 µm thick), undergo IKNM over the entire apicobasal extent, more apicobasally elongated (300 µm) neural progenitor cells (radial glial cells) in the mid-embryonic mouse cerebral wall move their nuclei only within its apical (100 µm) compartment, leaving the remaining basal region nucleus-free (fiber-like). How this IKNM range [i.e. the thickness of a pseudostratified ventricular zone (VZ)] is determined remains unknown. Here, we report external fencing of IKNM and the VZ by differentiating cells. When a tight stack of multipolar cells immediately basal to the VZ was ‘drilled’ via acute neuron-directed expression of diphtheria toxin, IKNM of apicobasally connected progenitor cells continued further towards the basal region of the cell (200 µm). The unfencing-induced basally overshot nuclei stay in S phase for too long and do not move apically, suggesting that external limitation of IKNM is necessary for progenitors to undergo normal cytogenetic behaviors. Thus, physical collaboration between progenitors and differentiating cells, including neurons, underlies brain development.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2019-07-17
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 The Company of Biologists
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1242/dev.162883
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0950-1991
ISSN(Online)
収録物識別子タイプ EISSN
収録物識別子 1477-9129
書誌情報 en : Development

巻 145, 号 14, p. dev162883, 発行日 2018-07-17
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