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Differentiating cells mechanically limit the interkinetic nuclear migration of progenitor cells to secure apical cytogenesis
http://hdl.handle.net/2237/00028794
http://hdl.handle.net/2237/000287946c2ddc92-e72a-44c5-af64-8feee64df1b1
名前 / ファイル | ライセンス | アクション |
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dev162883full (9.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-11-13 | |||||
タイトル | ||||||
タイトル | Differentiating cells mechanically limit the interkinetic nuclear migration of progenitor cells to secure apical cytogenesis | |||||
言語 | en | |||||
著者 |
Watanabe, Yuto
× Watanabe, Yuto× Kawaue, Takumi× Miyata, Takaki |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | © 2018. Published by The Company of Biologists Ltd | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Interkinetic nuclear migration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Radial glia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ventricular zone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pseudostratified epithelium | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Neocortex | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mouse | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Many proliferative epithelia are pseudostratified because of cell cycle-dependent interkinetic nuclear migration (IKNM, basal during G1 and apical during G2). Although most epithelia, including early embryonic neuroepithelia (≤100 µm thick), undergo IKNM over the entire apicobasal extent, more apicobasally elongated (300 µm) neural progenitor cells (radial glial cells) in the mid-embryonic mouse cerebral wall move their nuclei only within its apical (100 µm) compartment, leaving the remaining basal region nucleus-free (fiber-like). How this IKNM range [i.e. the thickness of a pseudostratified ventricular zone (VZ)] is determined remains unknown. Here, we report external fencing of IKNM and the VZ by differentiating cells. When a tight stack of multipolar cells immediately basal to the VZ was ‘drilled’ via acute neuron-directed expression of diphtheria toxin, IKNM of apicobasally connected progenitor cells continued further towards the basal region of the cell (200 µm). The unfencing-induced basally overshot nuclei stay in S phase for too long and do not move apically, suggesting that external limitation of IKNM is necessary for progenitors to undergo normal cytogenetic behaviors. Thus, physical collaboration between progenitors and differentiating cells, including neurons, underlies brain development. | |||||
言語 | en | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | ファイル公開:2019-07-17 | |||||
言語 | ja | |||||
出版者 | ||||||
出版者 | The Company of Biologists | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1242/dev.162883 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0950-1991 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 1477-9129 | |||||
書誌情報 |
en : Development 巻 145, 号 14, p. dev162883, 発行日 2018-07-17 |
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著者版フラグ | ||||||
値 | publisher |