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  1. C100 医学部/医学系研究科
  2. C100b 刊行物
  3. Nagoya journal of medical science
  4. 80(4)

Analysis of late adverse events and their chronological changes after radiation therapy for cervical cancer

https://doi.org/10.18999/nagjms.80.4.487
https://doi.org/10.18999/nagjms.80.4.487
bf307da1-d4e8-49b7-9614-95ff5eeff823
名前 / ファイル ライセンス アクション
05_Yamada.pdf 05_Yamada (677.5 kB)
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Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2019-01-18
タイトル
タイトル Analysis of late adverse events and their chronological changes after radiation therapy for cervical cancer
言語 en
著者 Yamada, Takehiro

× Yamada, Takehiro

WEKO 88487

en Yamada, Takehiro

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Ishihara, Shunichi

× Ishihara, Shunichi

WEKO 88488

en Ishihara, Shunichi

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Kawai, Michiyasu

× Kawai, Michiyasu

WEKO 88489

en Kawai, Michiyasu

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Itoh, Yoshiyuki

× Itoh, Yoshiyuki

WEKO 88490

en Itoh, Yoshiyuki

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Naganawa, Shinji

× Naganawa, Shinji

WEKO 88491

en Naganawa, Shinji

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Ikeda, Mitsuru

× Ikeda, Mitsuru

WEKO 88492

en Ikeda, Mitsuru

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報Resource http://creativecommons.org/licenses/by-nc-nd/4.0/
権利情報 Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
キーワード
主題Scheme Other
主題 cervical cancer
キーワード
主題Scheme Other
主題 radiation therapy
キーワード
主題Scheme Other
主題 concurrent chemoradiotherapy
キーワード
主題Scheme Other
主題 late adverse event
キーワード
主題Scheme Other
主題 chronological changes
抄録
内容記述タイプ Abstract
内容記述 Several late adverse events occur after radiation therapy (RT) for cervical cancer. However, there has been little reported about their chronological changes. It is still unclear whether concurrent chemoradiotherapy (CCRT) increases late complications. We aimed to evaluate the late adverse events and their chronological changes and whether CCRT increases their incidence and severity. For this purpose, we retrospectively analyzed 157 women with histologically proven cervical cancer. We reviewed all late adverse events and compared the frequency and severity between the patients who underwent CCRT and those who underwent RT alone. We calculated the cumulative occurrence rates of late adverse events stratified by the site and severity, and determined the chronological changes. With survivors’ median follow-up time of 74.3 months, late adverse events occurred in 49.0% and serious complications developed in 24.2% of all patients. There was no significant difference in the cumulative incidence rate of all late adverse events between the CCRT and RT-alone groups (p = 0.720). The incidence rate of rectal bleeding was 25.5%. Serious rectal bleeding developed in 5 patients, all within 20 months from the start of RT. Importantly, the symptoms of rectal bleeding disappeared or were relieved in most patients during follow-up. In conclusion, we evaluated the late adverse events and their chronological changes after RT for cervical cancer and showed that adding chemotherapy to RT did not affect the frequency and severity of late complications, and the symptoms of rectal bleeding were relieved over time.
言語 en
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語 en
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/nagjms.80.4.487
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/804.html
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ EISSN
収録物識別子 2186-3326
書誌情報 en : Nagoya Journal of Medical Science

巻 80, 号 4, p. 487-496, 発行日 2018-11
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