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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 80(4)

Polymorphisms in folic acid metabolism genes do not associate with cancer cachexia in Japanese gastrointestinal patients

https://doi.org/10.18999/nagjms.80.4.529
https://doi.org/10.18999/nagjms.80.4.529
78a58e15-e993-4514-b589-3524f3e0f6c6
名前 / ファイル ライセンス アクション
09_Morishita.pdf 09_Morishita.pdf (883.1 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2019-01-18
タイトル
タイトル Polymorphisms in folic acid metabolism genes do not associate with cancer cachexia in Japanese gastrointestinal patients
著者 Morishita, Takuto

× Morishita, Takuto

WEKO 88513

Morishita, Takuto

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Hishida, Asahi

× Hishida, Asahi

WEKO 88514

Hishida, Asahi

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Okugawa, Yoshinaga

× Okugawa, Yoshinaga

WEKO 88515

Okugawa, Yoshinaga

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Morimoto, Yuuki

× Morimoto, Yuuki

WEKO 88516

Morimoto, Yuuki

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Shirai, Yumiko

× Shirai, Yumiko

WEKO 88517

Shirai, Yumiko

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Okamoto, Kyoko

× Okamoto, Kyoko

WEKO 88518

Okamoto, Kyoko

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Momokita, Sachiko

× Momokita, Sachiko

WEKO 88519

Momokita, Sachiko

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Ogawa, Aki

× Ogawa, Aki

WEKO 88520

Ogawa, Aki

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Tanaka, Koji

× Tanaka, Koji

WEKO 88521

Tanaka, Koji

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Nishikawa, Ryutaro

× Nishikawa, Ryutaro

WEKO 88522

Nishikawa, Ryutaro

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Toiyama, Yuji

× Toiyama, Yuji

WEKO 88523

Toiyama, Yuji

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Inoue, Yasuhiro

× Inoue, Yasuhiro

WEKO 88524

Inoue, Yasuhiro

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Sakurai, Hiroyuki

× Sakurai, Hiroyuki

WEKO 88525

Sakurai, Hiroyuki

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Urata, Hisashi

× Urata, Hisashi

WEKO 88526

Urata, Hisashi

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Tanaka, Motoyoshi

× Tanaka, Motoyoshi

WEKO 88527

Tanaka, Motoyoshi

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Miki, Chikao

× Miki, Chikao

WEKO 88528

Miki, Chikao

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キーワード
主題Scheme Other
主題 gastrointestinal cancer
キーワード
主題Scheme Other
主題 single nucleotide polymorphism
キーワード
主題Scheme Other
主題 folic acid metabolism
キーワード
主題Scheme Other
主題 cancer cachexia
抄録
内容記述 We used clinical data from Iga General Hospital to examine the association between polymorphisms in MTR (methionine synthase) A2756G (rs1805087), MTRR (methionine synthase reductase) His595Tyr (rs10380), MTHFR (methylenetetrahydrofolate reductase) C677T (rs1801133), MTHFR A1298C (rs1801131) and SHMT (serine hydroxymethyltransferase) C1420T (rs1979277), which are genes involved in folate metabolism, and the risk of weight loss in patients with gastrointestinal cancers, with the aim of establishing personalized palliative care for each patient based on genetic information. The data from 59 patients (37 males and 22 females) with gastrointestinal cancers who visited the outpatient clinic for cancer chemotherapy and palliative care at Iga General Hospital from December 2011 to August 2015 were analyzed. There was no significant association between the single nucleotide polymorphisms (SNPs) in the folate metabolizing genes examined and weight loss defined as weight loss of more than 5 percent or more than 10 percent during the first 6 months after initiation of chemotherapy. We did not detect any significant association between any of the SNPs examined and overall survival of patients. The present study indicated that these SNPs have relatively limited or no roles in the genesis of cachexia in patients with gastrointestinal cancers; however, further investigations into the roles of these folate metabolizing genes in the context of cancer palliative care, from clinical, biological and epidemiological viewpoints are warranted.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.80.4.529
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/804.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 80, 号 4, p. 529-539, 発行日 2018-11
著者版フラグ
値 publisher
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