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Polymorphisms in folic acid metabolism genes do not associate with cancer cachexia in Japanese gastrointestinal patients
https://doi.org/10.18999/nagjms.80.4.529
https://doi.org/10.18999/nagjms.80.4.52978a58e15-e993-4514-b589-3524f3e0f6c6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
09_Morishita.pdf (883.1 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-01-18 | |||||
| タイトル | ||||||
| タイトル | Polymorphisms in folic acid metabolism genes do not associate with cancer cachexia in Japanese gastrointestinal patients | |||||
| 言語 | en | |||||
| 著者 |
Morishita, Takuto
× Morishita, Takuto× Hishida, Asahi× Okugawa, Yoshinaga× Morimoto, Yuuki× Shirai, Yumiko× Okamoto, Kyoko× Momokita, Sachiko× Ogawa, Aki× Tanaka, Koji× Nishikawa, Ryutaro× Toiyama, Yuji× Inoue, Yasuhiro× Sakurai, Hiroyuki× Urata, Hisashi× Tanaka, Motoyoshi× Miki, Chikao |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報Resource | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| 権利情報 | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | gastrointestinal cancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | single nucleotide polymorphism | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | folic acid metabolism | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cancer cachexia | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We used clinical data from Iga General Hospital to examine the association between polymorphisms in MTR (methionine synthase) A2756G (rs1805087), MTRR (methionine synthase reductase) His595Tyr (rs10380), MTHFR (methylenetetrahydrofolate reductase) C677T (rs1801133), MTHFR A1298C (rs1801131) and SHMT (serine hydroxymethyltransferase) C1420T (rs1979277), which are genes involved in folate metabolism, and the risk of weight loss in patients with gastrointestinal cancers, with the aim of establishing personalized palliative care for each patient based on genetic information. The data from 59 patients (37 males and 22 females) with gastrointestinal cancers who visited the outpatient clinic for cancer chemotherapy and palliative care at Iga General Hospital from December 2011 to August 2015 were analyzed. There was no significant association between the single nucleotide polymorphisms (SNPs) in the folate metabolizing genes examined and weight loss defined as weight loss of more than 5 percent or more than 10 percent during the first 6 months after initiation of chemotherapy. We did not detect any significant association between any of the SNPs examined and overall survival of patients. The present study indicated that these SNPs have relatively limited or no roles in the genesis of cachexia in patients with gastrointestinal cancers; however, further investigations into the roles of these folate metabolizing genes in the context of cancer palliative care, from clinical, biological and epidemiological viewpoints are warranted. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University Graduate School of Medicine, School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.80.4.529 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/804.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 80, 号 4, p. 529-539, 発行日 2018-11 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
