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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 80(4)

An open-label trial of the prophylactic administration of voriconazole in patients who undergo allogeneic hematopoietic stem cell transplantation: study protocol

https://doi.org/10.18999/nagjms.80.4.591
https://doi.org/10.18999/nagjms.80.4.591
7e522f00-7881-471f-a635-11f4a86f8f46
名前 / ファイル ライセンス アクション
15_Kunitomi.pdf 15_Kunitomi.pdf (178.5 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2019-01-18
タイトル
タイトル An open-label trial of the prophylactic administration of voriconazole in patients who undergo allogeneic hematopoietic stem cell transplantation: study protocol
著者 Kunitomi, Akane

× Kunitomi, Akane

WEKO 88557

Kunitomi, Akane

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Hasegawa, Yuta

× Hasegawa, Yuta

WEKO 88558

Hasegawa, Yuta

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Hashimoto, Hiroya

× Hashimoto, Hiroya

WEKO 88559

Hashimoto, Hiroya

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Saito, Akiko M.

× Saito, Akiko M.

WEKO 88560

Saito, Akiko M.

Search repository
Iida, Hiroatsu

× Iida, Hiroatsu

WEKO 88561

Iida, Hiroatsu

Search repository
キーワード
主題Scheme Other
主題 invasive fungal infection
キーワード
主題Scheme Other
主題 voriconazole
キーワード
主題Scheme Other
主題 allogeneic hematopoietic stem cell transplantation
抄録
内容記述 Invasive fungal infections, especially those caused by Aspergillus, can be fatal in patients who have undergone allogeneic hematopoietic stem cell transplantation. Fluconazole, itraconazole and micafungin can be used to prevent fungal infections in patients undergoing allogeneic hematopoietic stem cell transplantation, but fluconazole is not effective against Aspergillus, and itraconazole has less tolerability from gastrointestinal toxicity. Micafungin is approved for prophylaxis at a dose of 50 mg/day, less than a therapeutic dose. Voriconazole, the current preferred agent for invasive Aspergillus infection, is available in both oral and intravenous preparations, and has recently been approved for prophylaxis in Japan. Some US and European studies have reported on the prophylactic use of voriconazole, but the efficacy and safety of this has not been confirmed in Japan. Hence, this prospective study of voriconazole as prophylaxis against invasive fungal infections in patients who have received allogeneic hematopoietic stem cell transplantation is being performed to evaluate its efficacy and safety, including incidence rate of proven/probable invasive aspergillosis and other fungal infections, and adverse event(s) due to voriconazole administration. We are also investigating potential interactions between voriconazole and immunosuppressive drugs by monitoring the blood concentration of a calcineurin inhibitor in Japanese patients. Further, this study aims to improve the clinical outcomes of allogeneic hematopoietic stem cell transplantation recipients.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.80.4.591
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/804.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 80, 号 4, p. 591-595, 発行日 2018-11
著者版フラグ
値 publisher
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