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Effects of hypnotics on prefrontal cortex activity during a verbal fluency task in healthy male subjects: A near-infrared spectroscopy study
http://hdl.handle.net/2237/00029393
http://hdl.handle.net/2237/000293932f1e4d7c-5205-4096-970e-aeb9216419a6
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180808NIRS&hypnotics (105.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-03-06 | |||||
| タイトル | ||||||
| タイトル | Effects of hypnotics on prefrontal cortex activity during a verbal fluency task in healthy male subjects: A near-infrared spectroscopy study | |||||
| 言語 | en | |||||
| 著者 |
Tsuruta, Yoshiyuki
× Tsuruta, Yoshiyuki× Iwamoto, Kunihiro× Banno, Masahiro× Kawano, Naoko× Kohmura, Kunihiro× Miyata, Seiko× Fujishiro, Hiroshige× Noda, Yukihiro× Noda, Akiko× Iritani, Shuji× Ozaki, Norio |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | This is the peer reviewed version of the following article: [Tsuruta Y, Iwamoto K, Banno M, et al. Effects of hypnotics on prefrontal cortex activity during a verbal fluency task in healthy male subjects: A near‐infrared spectroscopy study. Hum Psychopharmacol Clin Exp. 2018;33:e2678. https://doi.org/10.1002/hup.2678], which has been published in final form at [https://doi.org/10.1002/hup.2678]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | brain activity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hypnotics | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | near‐infrared spectroscopy (NIRS) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ramelteon | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sleepiness | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | triazolam | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: To assess the effects of hypnotics on prefrontal cortex activity in healthy subjects using near‐infrared spectroscopy (NIRS) in a double‐blind, placebo‐controlled crossover trial. Methods: Eighteen healthy males received acute doses of ramelteon (8 mg), triazolam (0.125 mg), or placebo in a predetermined randomization schedule, with a washout period of more than 1 week. All subjects performed a verbal fluency task during NIRS assessments at baseline and at 1 and 4 hr post‐dose. The number of words correctly generated during the task (behavioral performance) and scores on the Stanford Sleepiness Scale (SSS) were also recorded at each test time. Results: Compared with the placebo, triazolam (0.125 mg) significantly decreased oxyhemoglobin (oxy‐Hb) concentration change in NIRS during the posttask period and significantly increased behavioral performance, whereas triazolam (0.125 mg) and ramelteon (8 mg) significantly increased SSS scores. Conclusions: The differential effects of two types of hypnotics on oxy‐Hb change measured by NIRS were observed in acute dosing, suggesting that when assessing brain activity of patients with psychiatric disorders, researchers should consider how certain types of hypnotics can influence brain function. This would also provide useful information to clinicians when prescribing hypnotics suitable for their patients' conditions. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ファイル公開：2019-11-01 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Wiley | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1002/hup.2678 | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0885-6222 | |||||
| 書誌情報 |
en : Human Psychopharmacology: Clinical and Experimental 巻 33, 号 6, p. e2678, 発行日 2018-11 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
