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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 81(1)

Meddling with meddlers: curbing regulatory T cells and augmenting antitumor immunity

https://doi.org/10.18999/nagjms.81.1.1
https://doi.org/10.18999/nagjms.81.1.1
e71f6cbc-ed04-44ef-8137-29bd67fea148
名前 / ファイル ライセンス アクション
01_Vitaly_Kochin.pdf 01_Vitaly_Kochin.pdf (783.1 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2019-03-15
タイトル
タイトル Meddling with meddlers: curbing regulatory T cells and augmenting antitumor immunity
著者 Kochin, Vitaly

× Kochin, Vitaly

WEKO 89396

Kochin, Vitaly

Search repository
Nishikawa, Hiroyoshi

× Nishikawa, Hiroyoshi

WEKO 89397

Nishikawa, Hiroyoshi

Search repository
キーワード
主題Scheme Other
主題 regulatory T cells
キーワード
主題Scheme Other
主題 Foxp3
キーワード
主題Scheme Other
主題 immune suppression
キーワード
主題Scheme Other
主題 tumor antigens
キーワード
主題Scheme Other
主題 immune checkpoints
抄録
内容記述 CD4+ regulatory T cells (Tregs) expressing the transcription factor forkhead box P3 (FoxP3) play an important role in self-tolerance and immune homeostasis. Tregs have evolved to protect the host from aberrant immune responses against self-components and collateral damages occurring in the process of defense against invading pathogens by softening immune responses. However, they turned to be a scourge in malignant tumors by not only allowing and promoting tumor growth but also suppressing effective antitumor actions, both inherent (host’s immune surveillance) and extrinsic (anticancer therapy). An increase in the number of Tregs infiltrating into tumor sites and a concomitant decrease in the number of CD8+ cytotoxic T lymphocytes are associated with a poor prognosis for various types of cancers, marking Tregs as notorious meddlers with an effective antitumor response. Various cancer immunotherapy approaches are often dampened by meddling Tregs, making them one of the major targets in the treatment of cancer. The recent success of immune checkpoint inhibitors (ICIs) that target immune checkpoint molecules expressed by Tregs or effector T cells implies, that “meddling with meddlers” represents an effective strategy in cancer immunotherapy. However, clinical responses to ICIs are effective and durable only in some patients with cancer, whereas more than half of them do not show significant clinical improvement. This implies that a therapeutic approach based on the use of a single ICI, or targeting Tregs alone, is insufficient, highlighting the need for combinatorial approaches. With regard to antitumor immune stimulation, several approaches, such as vaccination with peptides (or the corresponding DNA) to stimulate antigen-presenting CD8+ T cells with tumor-specific neoantigens, cancer/testis antigens, or cancer stem cell antigens, that eventually boost effective cytotoxic antitumor responses are being tested. This review describes the immunosuppressive physiology of Tregs and their meddling with the host’s antitumor immunity; current and prospective approaches to curb Tregs; and approaches to augment antitumor immunity.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.81.1.1
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/811.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 81, 号 1, p. 1-18, 発行日 2019-02
著者版フラグ
値 publisher
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