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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Feasibility and effects of a self-assembling peptide as a scaffold in bone healing: An in vivo study in rabbit lumbar posterolateral fusion and tibial intramedullary models

http://hdl.handle.net/2237/00030222
http://hdl.handle.net/2237/00030222
3ade49f8-a09a-44d9-ad35-de59b7740903
名前 / ファイル ライセンス アクション
20180716Manuscript.pdf 20180716Manuscript (210.0 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-05-15
タイトル
タイトル Feasibility and effects of a self-assembling peptide as a scaffold in bone healing: An in vivo study in rabbit lumbar posterolateral fusion and tibial intramedullary models
言語 en
著者 Ando, Kei

× Ando, Kei

WEKO 91258

en Ando, Kei

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Imagama, Shiro

× Imagama, Shiro

WEKO 91259

en Imagama, Shiro

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Kobayashi, Kazuyoshi

× Kobayashi, Kazuyoshi

WEKO 91260

en Kobayashi, Kazuyoshi

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Ito, Kenyu

× Ito, Kenyu

WEKO 91261

en Ito, Kenyu

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Tsushima, Mikito

× Tsushima, Mikito

WEKO 91262

en Tsushima, Mikito

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Morozumi, Masayoshi

× Morozumi, Masayoshi

WEKO 91263

en Morozumi, Masayoshi

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Tanaka, Satoshi

× Tanaka, Satoshi

WEKO 91264

en Tanaka, Satoshi

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Machino, Masaaki

× Machino, Masaaki

WEKO 91265

en Machino, Masaaki

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Ota, Kyotaro

× Ota, Kyotaro

WEKO 91266

en Ota, Kyotaro

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Nishida, Koji

× Nishida, Koji

WEKO 91267

en Nishida, Koji

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Nishida, Yoshihiro

× Nishida, Yoshihiro

WEKO 91268

en Nishida, Yoshihiro

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Ishiguro, Naoki

× Ishiguro, Naoki

WEKO 91269

en Ishiguro, Naoki

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the peer reviewed version of the following article: [Ando, K. , Imagama, S. , Kobayashi, K. , Ito, K. , Tsushima, M. , Morozumi, M. , Tanaka, S. , Machino, M. , Ota, K. , Nishida, K. , Nishida, Y. and Ishiguro, N. (2018), Feasibility and effects of a self‐assembling peptide as a scaffold in bone healing: An in vivo study in rabbit lumbar posterolateral fusion and tibial intramedullary models. J. Orthop. Res., 36: 3285-3293. doi:10.1002/jor.24109], which has been published in final form at [https://doi.org/10.1002/jor.24109]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
キーワード
主題Scheme Other
主題 self‐assembling peptide
キーワード
主題Scheme Other
主題 scaffold
キーワード
主題Scheme Other
主題 bone healing
抄録
内容記述 Spinal fusion and bone defects after injuries, removal of bone tumors, and infections require repair by implantation. In this study, we show self‐assembling peptide (SPG‐178) hydrogel‐induced bone healing in vivo. Posterolateral lumbar fusion and tibial intramedullary models of rabbits were prepared. In the tibia model, micro‐CT analysis revealed a significantly higher degree of newly formed bone matrix in the SPG‐178 group compared to the other groups. SEM/3D micrographs showed that the cavity filled with SPG‐178 had collagen fibers attached to host bone. After 28 days, samples from the SPG‐178 group showed significant repair of the defect. In the posterolateral lumbar fusion models, micro‐CT showed a tendency for a higher degree of newly formed bone matrix in the SPG‐178 group compared to the β‐TCP and bone chips only groups. Von Kossa staining showed marked new bone formation attached to the lamina that was most prominent at the implanted SPG‐178 composite margin. SPG‐178 is a material that is likely to be used in clinical applications because it has several benefits. These include its favorable bone conduction properties, its ability to act as a support for various cells and growth factors, its lack of infection risk compared with materials of animal origin such as ECM, and the ease with which it can be used to fill defects with complex shapes and be combined with a wide range of other materials.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2019-12-01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/jor.24109
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0736-0266
書誌情報 en : Journal of Orthopaedic Research

巻 36, 号 12, p. 3285-3293, 発行日 2018-12
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