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  1. B100 理学部/理学研究科
  2. B100a 雑誌掲載論文
  3. 学術雑誌

Energy Exchange Network Model Demonstrates Protein Allosteric Transition: An Application to an Oxygen Sensor Protein

http://hdl.handle.net/2237/00030423
http://hdl.handle.net/2237/00030423
9017eb3b-a970-4f9c-b5eb-eb1dfb570340
名前 / ファイル ライセンス アクション
FixL-paper-Ota-Yamato.pdf FixL-paper-Ota-Yamato (935.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-06-12
タイトル
タイトル Energy Exchange Network Model Demonstrates Protein Allosteric Transition: An Application to an Oxygen Sensor Protein
言語 en
著者 Ota, Kunitaka

× Ota, Kunitaka

WEKO 91919

en Ota, Kunitaka

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Yamato, Takahisa

× Yamato, Takahisa

WEKO 91920

en Yamato, Takahisa

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 “This document is the Accepted Manuscript version of a Published Work that appeared in final form in [The Journal of Physical Chemistry B], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [https://pubs.acs.org/articlesonrequest/AOR-qidz7b2n9mIhAanR8bRT].”
抄録
内容記述タイプ Abstract
内容記述 The effects of ligand binding on an oxygen sensor protein, FixLH, were investigated by molecular dynamics simulation. To illustrate the network of residue interactions in the deoxy, oxy, and carbomonoxy states of FixLH, we employed the energy exchange network (EEN) model in which residue interactions were evaluated in terms of local transport coefficients of energy flow. As a result, the difference map of EEN between the deoxy and oxy (deoxy and carbomonooxy) states clearly demonstrated the allosteric transition, although the structural changes by ligand binding are small. It is known that the FixLH forms a homodimer in solution, although neither O2 nor CO binding exhibits cooperativity. Therefore, we conjectured that the primary event after ligand binding occurs essentially at the monomer level, and it is subsequently followed by quaternary structural changes. The difference EEN maps showed that two regions, (A) the junction between the coiled-coil linker and the sensor domain and (B) the potential dimer interface, experienced considerable change of the energy-transport coefficients, indicating that these two regions play important roles in quaternary structural changes and signal transduction in response to ligand binding.
言語 en
内容記述
内容記述タイプ Other
内容記述 ファイル公開:2020-01-31
言語 ja
出版者
出版者 ACS Publications
言語 en
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1021/acs.jpcb.8b10489
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 1520-6106
書誌情報 en : The Journal of Physical Chemistry B

巻 123, 号 4, p. 768-775, 発行日 2019-01-31
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