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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Relatively high rates of cefotaxime- and ceftriaxone-non-susceptible isolates among group B streptococci with reduced penicillin susceptibility (PRGBS) in Japan

http://hdl.handle.net/2237/00030530
http://hdl.handle.net/2237/00030530
0de127fd-166d-44bc-9c82-bad62edfb872
名前 / ファイル ライセンス アクション
KItamuraJAC.pdf KItamuraJAC (666.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-07-10
タイトル
タイトル Relatively high rates of cefotaxime- and ceftriaxone-non-susceptible isolates among group B streptococci with reduced penicillin susceptibility (PRGBS) in Japan
言語 en
著者 Kitamura, Masaki

× Kitamura, Masaki

WEKO 92527

en Kitamura, Masaki

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Kimura, Kouji

× Kimura, Kouji

WEKO 92528

en Kimura, Kouji

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Ido, Ayaka

× Ido, Ayaka

WEKO 92529

en Ido, Ayaka

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Seki, Tomomi

× Seki, Tomomi

WEKO 92530

en Seki, Tomomi

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Banno, Hirotsugu

× Banno, Hirotsugu

WEKO 92531

en Banno, Hirotsugu

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Jin, Wanchun

× Jin, Wanchun

WEKO 92532

en Jin, Wanchun

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Wachino, Jun-ichi

× Wachino, Jun-ichi

WEKO 92533

en Wachino, Jun-ichi

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Yamada, Keiko

× Yamada, Keiko

WEKO 92534

en Yamada, Keiko

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Arakawa, Yoshichika

× Arakawa, Yoshichika

WEKO 92535

en Arakawa, Yoshichika

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is a pre-copyedited, author-produced version of an article accepted for publication in [Journal of Antimicrobial Chemotherapy] following peer review. The version of record [Masaki Kitamura, Kouji Kimura, Ayaka Ido, Tomomi Seki, Hirotsugu Banno, Wanchun Jin, Jun-ichi Wachino, Keiko Yamada, Yoshichika Arakawa, Relatively high rates of cefotaxime- and ceftriaxone-non-susceptible isolates among group B streptococci with reduced penicillin susceptibility (PRGBS) in Japan, Journal of Antimicrobial Chemotherapy, Volume 74, Issue 4, April 2019, Pages 931–934, https://doi.org/10.1093/jac/dky542] is available online at: http://doi.org/10.1093/jac/dky542.
抄録
内容記述 Objectives: We have previously identified group B Streptococcus (GBS) clinical isolates with reduced penicillin susceptibility (PRGBS) that were non-susceptible to cefotaxime; however, the rates of cefotaxime and ceftriaxone non-susceptibility among PRGBS isolates have never been reported. Therefore, we first determined the MICs of 22 antibacterial drugs/compounds for 74 PRGBS isolates and then determined the rates of cefotaxime and ceftriaxone non-susceptibility among these isolates. Methods: We used 74 clinical PRGBS isolates, previously collected in Japan and confirmed to harbour relevant amino acid substitutions in PBP2X. We also used 80 penicillin-susceptible GBS (PSGBS) clinical isolates as controls. The MICs of 22 antibacterial drugs/compounds for all 154 GBS isolates were determined via microdilution and/or agar dilution methods, as recommended by the CLSI. Results: The rates of non-susceptibility/resistance to ampicillin, cefotaxime, ceftriaxone and levofloxacin for the 80 PSGBS isolates were 0%, 0%, 0% and 30%, respectively, but were 15% (P = 0.0003), 28% (P < 0.0001), 36% (P < 0.0001) and 93% (P < 0.0001) for the 74 PRGBS isolates, respectively. No PRGBS isolates were identified to be non-susceptible to meropenem, doripenem, vancomycin, quinupristin/dalfopristin, daptomycin or linezolid. Conclusions: We found that cefotaxime- and ceftriaxone-non-susceptible PRGBS isolates occur at relatively high rates in Japan. Importantly, this finding suggests that the range of drugs likely to be effective in treating PRGBS infections may be limited compared with those available for PSGBS infections; therefore, clinicians should exercise care when considering drug choice and efficacy for PRGBS infections.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開日: 2020/04/01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Oxford University Press
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1093/jac/dky542
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0305-7453
書誌情報 en : Journal of Antimicrobial Chemotherapy

巻 74, 号 4, p. 931-934, 発行日 2019-04
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