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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Comparison of high-dose and low-dose corticosteroid therapy for refractory Mycoplasma pneumoniae pneumonia in children

http://hdl.handle.net/2237/00030546
http://hdl.handle.net/2237/00030546
1ea757ab-b1fa-4420-8157-306d77109f7c
名前 / ファイル ライセンス アクション
MS_Okumura_repository.pdf MS_Okumura_repository (452.3 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-07-11
タイトル
タイトル Comparison of high-dose and low-dose corticosteroid therapy for refractory Mycoplasma pneumoniae pneumonia in children
言語 en
著者 Okumura, Toshihiko

× Okumura, Toshihiko

WEKO 92627

en Okumura, Toshihiko

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Kawada, Jun-ichi

× Kawada, Jun-ichi

WEKO 92628

en Kawada, Jun-ichi

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Tanaka, Masaharu

× Tanaka, Masaharu

WEKO 92629

en Tanaka, Masaharu

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Narita, Kotaro

× Narita, Kotaro

WEKO 92630

en Narita, Kotaro

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Ishiguro, Tomonori

× Ishiguro, Tomonori

WEKO 92631

en Ishiguro, Tomonori

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Hirayama, Yuji

× Hirayama, Yuji

WEKO 92632

en Hirayama, Yuji

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Narahara, Sho

× Narahara, Sho

WEKO 92633

en Narahara, Sho

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Tsuji, Genki

× Tsuji, Genki

WEKO 92634

en Tsuji, Genki

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Sugiyama, Yuichiro

× Sugiyama, Yuichiro

WEKO 92635

en Sugiyama, Yuichiro

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Suzuki, Michio

× Suzuki, Michio

WEKO 92636

en Suzuki, Michio

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Tsuji, Takeshi

× Tsuji, Takeshi

WEKO 92637

en Tsuji, Takeshi

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Hoshino, Shin

× Hoshino, Shin

WEKO 92638

en Hoshino, Shin

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Nakatochi, Masahiro

× Nakatochi, Masahiro

WEKO 92639

en Nakatochi, Masahiro

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Muramatsu, Hideki

× Muramatsu, Hideki

WEKO 92640

en Muramatsu, Hideki

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Kidokoro, Hiroyuki

× Kidokoro, Hiroyuki

WEKO 92641

en Kidokoro, Hiroyuki

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Takahashi, Yoshiyuki

× Takahashi, Yoshiyuki

WEKO 92642

en Takahashi, Yoshiyuki

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Sato, Yoshiaki

× Sato, Yoshiaki

WEKO 92643

en Sato, Yoshiaki

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Miyajima, Yuji

× Miyajima, Yuji

WEKO 92644

en Miyajima, Yuji

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Uno, Nozomi

× Uno, Nozomi

WEKO 92645

en Uno, Nozomi

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Nagai, Noriko

× Nagai, Noriko

WEKO 92646

en Nagai, Noriko

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Ando, Shotaro

× Ando, Shotaro

WEKO 92647

en Ando, Shotaro

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Sudo, Yuji

× Sudo, Yuji

WEKO 92648

en Sudo, Yuji

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Naruse, Kazuhisa

× Naruse, Kazuhisa

WEKO 92649

en Naruse, Kazuhisa

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Takahashi, Yuma

× Takahashi, Yuma

WEKO 92650

en Takahashi, Yuma

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Suzui, Ryosuke

× Suzui, Ryosuke

WEKO 92651

en Suzui, Ryosuke

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Nagata, Yoshihiro

× Nagata, Yoshihiro

WEKO 92652

en Nagata, Yoshihiro

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Kawabe, Takashi

× Kawabe, Takashi

WEKO 92653

en Kawabe, Takashi

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Shibata, Motohiro

× Shibata, Motohiro

WEKO 92654

en Shibata, Motohiro

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Shibata, Yusuke

× Shibata, Yusuke

WEKO 92655

en Shibata, Yusuke

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Morishita, Masashi

× Morishita, Masashi

WEKO 92656

en Morishita, Masashi

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Kajita, Mitsuharu

× Kajita, Mitsuharu

WEKO 92657

en Kajita, Mitsuharu

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Ito, Takuto

× Ito, Takuto

WEKO 92658

en Ito, Takuto

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Kido, Shinji

× Kido, Shinji

WEKO 92659

en Kido, Shinji

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Hasegawa, Shinji

× Hasegawa, Shinji

WEKO 92660

en Hasegawa, Shinji

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Ikeda, Kei

× Ikeda, Kei

WEKO 92661

en Ikeda, Kei

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Tokumo, Noriko

× Tokumo, Noriko

WEKO 92662

en Tokumo, Noriko

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Kato, Maki

× Kato, Maki

WEKO 92663

en Kato, Maki

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Kato, Koji

× Kato, Koji

WEKO 92664

en Kato, Koji

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Fukumi, Daichi

× Fukumi, Daichi

WEKO 92665

en Fukumi, Daichi

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Doi, Satoru

× Doi, Satoru

WEKO 92666

en Doi, Satoru

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Omori, Marei

× Omori, Marei

WEKO 92667

en Omori, Marei

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Watanabe, Nobuhiro

× Watanabe, Nobuhiro

WEKO 92668

en Watanabe, Nobuhiro

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Takada, Hiroyuki

× Takada, Hiroyuki

WEKO 92669

en Takada, Hiroyuki

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
キーワード
主題Scheme Other
主題 Mycoplasma pneumoniae pneumonia
キーワード
主題Scheme Other
主題 Refractory pneumonia
キーワード
主題Scheme Other
主題 Corticosteroids
抄録
内容記述 Background: Mycoplasma pneumoniae pneumonia (MPP) is generally a self-limiting disease, but it may become refractory. It is thought that refractory MPP is linked to the excessive immunologic responses of the host. Consequently, the use of adjunctive systemic corticosteroids may have beneficial effects. In this study, we compared the effects of high- and low-dose corticosteroid therapy in a pediatric population with refractory MPP. Methods: We retrospectively collected data from 91 pediatric MPP patients treated with adjunctive systemic corticosteroids between April 2014 and October 2016. The patients were divided into the following two groups: high-dose corticosteroid group (2 mg/kg/day or more of prednisolone equivalents; n = 38) and low-dose corticosteroid group (<2 mg/kg/day; n = 53). Additionally, we compared the number of febrile days post-corticosteroid administration. We used 25 paired patients in a propensity score matching analysis to correct for confounding factors both by age and by days (from onset till corticosteroid therapy initiation). Results: We observed that in the high-dose corticosteroid group defervescence following corticosteroid therapy initiation was achieved significantly earlier and length of hospitalization was significantly shorter (0.8 ± 1.0 vs. 1.5 ± 1.4 days and 8.2 ± 2.4 vs. 10.7 ± 2.7 days, respectively). In the propensity score matching, we observed that significant differences in the length of fever following corticosteroid therapy initiation and hospitalization were still present. Further, neither of the groups developed corticosteroid-related adverse events. Conclusion: Our results suggest that patients with refractory MPP treated with high-dose corticosteroid could achieve defervescence earlier and have a shorter hospitalization.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2020-05-01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.jiac.2019.01.003
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 1341-321X
書誌情報 en : Journal of Infection and Chemotherapy

巻 25, 号 5, p. 346-350, 発行日 2019-05
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