{"_buckets": {"deposit": "bd615408-5ff5-451e-8c8b-af826502d5de"}, "_deposit": {"id": "28368", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "28368"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00028368"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "498", "bibliographicPageStart": "491", "bibliographicVolumeNumber": "109", "bibliographic_titles": [{"bibliographic_title": "International Journal of Hematology"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "We investigated the safety and efficacy of mycophenolate mofetil (MMF) in the prevention and treatment of graft-versus-host disease (GVHD) using a nationwide retrospective survey in Japanese children undergoing hematopoietic stem cell transplantation (HSCT). Overall, 141 children undergoing allogeneic HSCT for hematological malignancy (n\u2009=\u200984), non-malignancy (n\u2009=\u200952), and solid tumors (n\u2009=\u20095) were administered MMF orally (median 8 years; range 0\u201315 years; 89 males and 52 females) during 1995\u20132011. Donors were primarily unrelated and mismatched related. In the GVHD prophylaxis group, 29% and 8.6% of patients developed grade II\u2013IV and III\u2013IV GVHD, respectively. Of the 32 evaluable patients, 16% developed chronic [limited (n\u2009=\u20094) and extensive (n\u2009=\u20091)] GVHD. In the acute GVHD treatment group, 61% had decreased grade. In the chronic GVHD treatment group, 36% had improved symptoms. Combined immunosuppressant was reduced or discontinued in 61% patients. Major adverse events (AEs) were neutropenia (4.3%), infection (3.5%), thrombocytopenia (2.1%), myelosuppression (2.1%), and diarrhea (1.4%). MMF dosage was reduced in two children due to grade\u2009\u2265\u20093 AEs; two children died from infection. MMF thus may be well tolerated in children, and may be an effective option for prophylaxis and treatment of acute and chronic GVHD.", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u30d5\u30a1\u30a4\u30eb\u516c\u958b\uff1a2020/04/01", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1007/s12185-019-02601-5", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u201cThis is a post-peer-review, pre-copyedit version of an article published in [International Journal of Hematology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12185-019-02601-5\u201d."}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0925-5710", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kawashima, Nozomu"}], "nameIdentifiers": [{"nameIdentifier": "92724", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iida, Minako"}], "nameIdentifiers": [{"nameIdentifier": "92725", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Ritsuro"}], "nameIdentifiers": [{"nameIdentifier": "92726", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukuda, Takahiro"}], "nameIdentifiers": [{"nameIdentifier": "92727", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Atsuta, Yoshiko"}], "nameIdentifiers": [{"nameIdentifier": "92728", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hashii, Yoshiko"}], "nameIdentifiers": [{"nameIdentifier": "92729", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Inoue, Masami"}], "nameIdentifiers": [{"nameIdentifier": "92730", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobayashi, Masao"}], "nameIdentifiers": [{"nameIdentifier": "92731", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yabe, Hiromasa"}], "nameIdentifiers": [{"nameIdentifier": "92732", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okada, Keiko"}], "nameIdentifiers": [{"nameIdentifier": "92733", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Adachi, Souichi"}], "nameIdentifiers": 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480600.0, "url": {"label": "MMF_for_Pediatric_HSCT_MS9_IJH1", "url": "https://nagoya.repo.nii.ac.jp/record/28368/files/MMF_for_Pediatric_HSCT_MS9_IJH1.pdf"}, "version_id": "389904d1-71df-4397-af75-7adcba6cff0a"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-04-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "IJH_PedMMF_Suppl.pdf", "filesize": [{"value": "436.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 436900.0, "url": {"label": "IJH_PedMMF_Suppl", "url": "https://nagoya.repo.nii.ac.jp/record/28368/files/IJH_PedMMF_Suppl.pdf"}, "version_id": "1d51cd39-5442-4a8c-94a1-9f0f608ded89"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Mycophenolate mofetil", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Graft-versus-host disease", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Prophylaxis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Treatment", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Pediatric", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Prophylaxis and treatment with mycophenolate mofetil in children with graft-versus-host disease undergoing allogeneic hematopoietic stem cell transplantation: a nationwide survey in Japan", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Prophylaxis and treatment with mycophenolate mofetil in children with graft-versus-host disease undergoing allogeneic hematopoietic stem cell transplantation: a nationwide survey in Japan"}]}, "item_type_id": "10", "owner": "1", "path": ["499/500/501"], "permalink_uri": "http://hdl.handle.net/2237/00030561", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2019-07-19"}, "publish_date": "2019-07-19", "publish_status": "0", "recid": "28368", "relation": {}, "relation_version_is_last": true, "title": ["Prophylaxis and treatment with mycophenolate mofetil in children with graft-versus-host disease undergoing allogeneic hematopoietic stem cell transplantation: a nationwide survey in Japan"], "weko_shared_id": null}