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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Prophylaxis and treatment with mycophenolate mofetil in children with graft-versus-host disease undergoing allogeneic hematopoietic stem cell transplantation: a nationwide survey in Japan

http://hdl.handle.net/2237/00030561
http://hdl.handle.net/2237/00030561
5e0fc1dd-86f9-4ea8-b250-faffc9ef9f4f
名前 / ファイル ライセンス アクション
MMF_for_Pediatric_HSCT_MS9_IJH1.pdf MMF_for_Pediatric_HSCT_MS9_IJH1 (480.6 kB)
IJH_PedMMF_Suppl.pdf IJH_PedMMF_Suppl (436.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-07-19
タイトル
タイトル Prophylaxis and treatment with mycophenolate mofetil in children with graft-versus-host disease undergoing allogeneic hematopoietic stem cell transplantation: a nationwide survey in Japan
言語 en
著者 Kawashima, Nozomu

× Kawashima, Nozomu

WEKO 92724

en Kawashima, Nozomu

Search repository
Iida, Minako

× Iida, Minako

WEKO 92725

en Iida, Minako

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Suzuki, Ritsuro

× Suzuki, Ritsuro

WEKO 92726

en Suzuki, Ritsuro

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Fukuda, Takahiro

× Fukuda, Takahiro

WEKO 92727

en Fukuda, Takahiro

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Atsuta, Yoshiko

× Atsuta, Yoshiko

WEKO 92728

en Atsuta, Yoshiko

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Hashii, Yoshiko

× Hashii, Yoshiko

WEKO 92729

en Hashii, Yoshiko

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Inoue, Masami

× Inoue, Masami

WEKO 92730

en Inoue, Masami

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Kobayashi, Masao

× Kobayashi, Masao

WEKO 92731

en Kobayashi, Masao

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Yabe, Hiromasa

× Yabe, Hiromasa

WEKO 92732

en Yabe, Hiromasa

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Okada, Keiko

× Okada, Keiko

WEKO 92733

en Okada, Keiko

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Adachi, Souichi

× Adachi, Souichi

WEKO 92734

en Adachi, Souichi

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Yuza, Yuki

× Yuza, Yuki

WEKO 92735

en Yuza, Yuki

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Kawa, Keisei

× Kawa, Keisei

WEKO 92736

en Kawa, Keisei

Search repository
Kato, Koji

× Kato, Koji

WEKO 92737

en Kato, Koji

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 “This is a post-peer-review, pre-copyedit version of an article published in [International Journal of Hematology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12185-019-02601-5”.
キーワード
主題Scheme Other
主題 Mycophenolate mofetil
キーワード
主題Scheme Other
主題 Graft-versus-host disease
キーワード
主題Scheme Other
主題 Prophylaxis
キーワード
主題Scheme Other
主題 Treatment
キーワード
主題Scheme Other
主題 Pediatric
抄録
内容記述 We investigated the safety and efficacy of mycophenolate mofetil (MMF) in the prevention and treatment of graft-versus-host disease (GVHD) using a nationwide retrospective survey in Japanese children undergoing hematopoietic stem cell transplantation (HSCT). Overall, 141 children undergoing allogeneic HSCT for hematological malignancy (n = 84), non-malignancy (n = 52), and solid tumors (n = 5) were administered MMF orally (median 8 years; range 0–15 years; 89 males and 52 females) during 1995–2011. Donors were primarily unrelated and mismatched related. In the GVHD prophylaxis group, 29% and 8.6% of patients developed grade II–IV and III–IV GVHD, respectively. Of the 32 evaluable patients, 16% developed chronic [limited (n = 4) and extensive (n = 1)] GVHD. In the acute GVHD treatment group, 61% had decreased grade. In the chronic GVHD treatment group, 36% had improved symptoms. Combined immunosuppressant was reduced or discontinued in 61% patients. Major adverse events (AEs) were neutropenia (4.3%), infection (3.5%), thrombocytopenia (2.1%), myelosuppression (2.1%), and diarrhea (1.4%). MMF dosage was reduced in two children due to grade ≥ 3 AEs; two children died from infection. MMF thus may be well tolerated in children, and may be an effective option for prophylaxis and treatment of acute and chronic GVHD.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2020/04/01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s12185-019-02601-5
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0925-5710
書誌情報 en : International Journal of Hematology

巻 109, 号 4, p. 491-498, 発行日 2019-04
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