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Genome–Epigenome–Senescence: Is TET1 a Caretaker of p53-Injured Lung Cancer Cells ?
http://hdl.handle.net/2237/00030587
http://hdl.handle.net/2237/0003058732e025a7-d338-4054-860f-239d288932a4
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-08-09 | |||||
タイトル | ||||||
タイトル | Genome–Epigenome–Senescence: Is TET1 a Caretaker of p53-Injured Lung Cancer Cells ? | |||||
言語 | en | |||||
著者 |
Kondo, Yutaka
× Kondo, Yutaka |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述 | The study by Filipczak and colleagues identified the interplay between mutant p53 proteins and methylcytosine dioxygenase ten-eleven translocation 1 (TET1) in lung cancers. p53 transversion mutations were closely associated with high TET1 expression, which prevented genomic instability–associated cellular senescence. Depletion of TET1 was synergistic with classical antitumor drugs, such as cisplatin or doxorubicin, providing an attractive rationale for targeted therapies against TET1 combined with antitumor drugs in patients with p53-mutant lung cancer. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | ファイル公開:2020/04/01 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | American Association for Cancer Research | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1158/0008-5472.CAN-19-0645 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0008-5472 | |||||
書誌情報 |
en : Cancer Research 巻 79, 号 8, p. 1751-1752, 発行日 2019-04 |
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著者版フラグ | ||||||
値 | author |