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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Divergence and heterogeneity of neoplastic PD‐L1 expression: Two autopsy case reports of intravascular large B‐cell lymphoma

http://hdl.handle.net/2237/00030594
http://hdl.handle.net/2237/00030594
52605f64-d1c5-4ff5-9d60-4ba30e5fb643
名前 / ファイル ライセンス アクション
A_Sakakibara.pdf A_Sakakibara (155.6 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-08-09
タイトル
タイトル Divergence and heterogeneity of neoplastic PD‐L1 expression: Two autopsy case reports of intravascular large B‐cell lymphoma
言語 en
著者 Sakakibara, Ayako

× Sakakibara, Ayako

WEKO 92939

en Sakakibara, Ayako

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Inagaki, Yuichiro

× Inagaki, Yuichiro

WEKO 92940

en Inagaki, Yuichiro

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Imaoka, Eiki

× Imaoka, Eiki

WEKO 92941

en Imaoka, Eiki

Search repository
Sakai, Yu

× Sakai, Yu

WEKO 92942

en Sakai, Yu

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Ito, Masafumi

× Ito, Masafumi

WEKO 92943

en Ito, Masafumi

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Ishikawa, Eri

× Ishikawa, Eri

WEKO 92944

en Ishikawa, Eri

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Shimada, Satoko

× Shimada, Satoko

WEKO 92945

en Shimada, Satoko

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Shimada, Kazuyuki

× Shimada, Kazuyuki

WEKO 92946

en Shimada, Kazuyuki

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Suzuki, Yuka

× Suzuki, Yuka

WEKO 92947

en Suzuki, Yuka

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Nakamura, Shigeo

× Nakamura, Shigeo

WEKO 92948

en Nakamura, Shigeo

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Satou, Akira

× Satou, Akira

WEKO 92949

en Satou, Akira

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Kohno, Kei

× Kohno, Kei

WEKO 92950

en Kohno, Kei

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the peer reviewed version of the following article: [Sakakibara, A. , Inagaki, Y. , Imaoka, E. , Sakai, Y. , Ito, M. , Ishikawa, E. , Shimada, S. , Shimada, K. , Suzuki, Y. , Nakamura, S. , Satou, A. and Kohno, K. (2019), Divergence and heterogeneity of neoplastic PD‐L1 expression: Two autopsy case reports of intravascular large B‐cell lymphoma. Pathol Int, 69: 148-154. doi:10.1111/pin.12757], which has been published in final form at [https://doi.org/10.1111/pin.12757]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
キーワード
主題Scheme Other
主題 autopsy
キーワード
主題Scheme Other
主題 intravascular large B‐cell lymphoma
キーワード
主題Scheme Other
主題 neoplastic PD‐L1 expression divergence or heterogeneity
抄録
内容記述 Intravascular large B‐cell lymphoma (IVLBCL) is a distinct disease, but the neoplastic PD‐L1 expression on tumor cells may vary among cases. We evaluated 10 IVLBCL autopsy cases for neoplastic PD‐L1 expression, and had positive results in two cases. In one case, neoplastic PD‐L1 expression (SP142, 28‐8, and E1J2J clones) was dependent on the organ and anatomical site (capillaries vs. vessels) of the tumor tissue. Neoplastic PD‐L1 expression was found in tumor cells located in capillaries in the central nervous system, pituitary gland, kidneys, lung, and gastrointestinal tract; sinuses/sinusoids of the spleen, liver, bone marrow, and lymph nodes; and an extravascular location. However, this expression was not detected in tumor cells located in the adrenal gland, thyroid gland, pancreas, ovaries, uterus, pleura, and small or larger‐sized vessels of the lung. The other case showed constant neoplastic PD‐L1 expression on the tumor cells, and in addition to the affected organs, capillaries, and vessels with two anti‐PD‐L1 antibodies (28‐8 and E1J2J, but not SP142). The divergence and heterogeneity of neoplastic PD‐L1 expression were clearly demonstrated in our cases. To the best of our knowledge, this is the first description of divergent neoplastic PD‐L1 expression among the affected organs and anatomical sites in IVLBCL.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2020-04-08
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/pin.12757
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 1320-5463
書誌情報 en : Pathology International

巻 69, 号 3, p. 148-154, 発行日 2019-04-08
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