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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 81(3)

Concurrent chemoradiotherapy with intravenous cisplatin and docetaxel for advanced oral cancer

https://doi.org/10.18999/nagjms.81.3.407
https://doi.org/10.18999/nagjms.81.3.407
a0b5dd7c-9a0d-4c49-8bef-831321637a39
名前 / ファイル ライセンス アクション
06_Sato.pdf 06_Sato.pdf (336.4 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2019-09-04
タイトル
タイトル Concurrent chemoradiotherapy with intravenous cisplatin and docetaxel for advanced oral cancer
著者 Sato, Kotaro

× Sato, Kotaro

WEKO 93127

Sato, Kotaro

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Hayashi, Yasushi

× Hayashi, Yasushi

WEKO 93128

Hayashi, Yasushi

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Watanabe, Kazuyo

× Watanabe, Kazuyo

WEKO 93129

Watanabe, Kazuyo

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Yoshimi, Ryoko

× Yoshimi, Ryoko

WEKO 93130

Yoshimi, Ryoko

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Hibi, Hideharu

× Hibi, Hideharu

WEKO 93131

Hibi, Hideharu

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キーワード
主題Scheme Other
主題 cisplatin
キーワード
主題Scheme Other
主題 docetaxel
キーワード
主題Scheme Other
主題 concurrent chemoradiotherapy
キーワード
主題Scheme Other
主題 oral cancer
抄録
内容記述 Concurrent chemoradiotherapy (CCRT) is a common treatment for advanced oral cancer, and its efficacy has been reported in many reviews. We have performed concurrent CCRT with intravenous cisplatin and docetaxel in patients with advanced oral cancer. The purpose of this report was to evaluate this treatment and to compare the outcome of this treatment with that of standard CCRT treatments for advanced head and neck cancer using intravenous administration. The patients were treated for primary advanced oral squamous cell carcinoma in our department between February 2003 and November 2015. In all, 17 patients (14 men, 3 women) with stage III (2 patients) stage IVA (10 patients), and stage IVB (5 patients) oral cancer were treated. The patient ages ranged from 44 to 87 years (average age: 65.4 years). The follow-up duration ranged from 5 to 117 months (average follow-up duration: 41 months, median follow-up duration: 39 months). The primary cancer sites were the maxillary gingiva (7 cases), mandible gingiva (3 cases), buccal mucosa (3 cases), tongue (3 cases), and floor of the mouth (1 case). The 3-year and 5-year survival rates were 52.9% and 33.0%, respectively, and both the 3-year and 5-year locoregional control rates were 50.9% as determined by the Kaplan-Meier method. The response rate was 94% (CR: 8 cases: 47% and PR: 8 cases: 47%). The incidences of toxicity greater than grade 3 included dermatitis and stomatitis in 9 cases each (52.9%), anemia in 3 cases (18.7%) and liver dysfunction in 1 case (6.2%). We found that the results of this therapy were equivalent to those of standard CCRT treatments for advanced head and neck cancer using intravenous administration, and the incidences of toxicity were lower than those of standard treatments. These findings suggested that this treatment is safe and useful for advanced oral cancer.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.81.3.407
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/813.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 81, 号 3, p. 407-414, 発行日 2019-08
著者版フラグ
値 publisher
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