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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 81(3)

Fatal case of TAFRO syndrome associated with over-immunosuppression: a case report and review of the literature

https://doi.org/10.18999/nagjms.81.3.519
https://doi.org/10.18999/nagjms.81.3.519
5982bddf-690f-4a6e-a99b-441dcee7eacc
名前 / ファイル ライセンス アクション
17_Matsuhisa.pdf 17_Matsuhisa.pdf (7.0 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2019-09-04
タイトル
タイトル Fatal case of TAFRO syndrome associated with over-immunosuppression: a case report and review of the literature
著者 Matsuhisa, Takaharu

× Matsuhisa, Takaharu

WEKO 93212

Matsuhisa, Takaharu

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Takahashi, Noriyuki

× Takahashi, Noriyuki

WEKO 93213

Takahashi, Noriyuki

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Nakaguro, Masato

× Nakaguro, Masato

WEKO 93214

Nakaguro, Masato

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Sato, Motoki

× Sato, Motoki

WEKO 93215

Sato, Motoki

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Inoue, Eri

× Inoue, Eri

WEKO 93216

Inoue, Eri

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Teshigawara, Shiho

× Teshigawara, Shiho

WEKO 93217

Teshigawara, Shiho

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Ozawa, Yukihiro

× Ozawa, Yukihiro

WEKO 93218

Ozawa, Yukihiro

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Kondo, Takeshi

× Kondo, Takeshi

WEKO 93219

Kondo, Takeshi

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Nakamura, Shigeo

× Nakamura, Shigeo

WEKO 93220

Nakamura, Shigeo

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Sato, Juichi

× Sato, Juichi

WEKO 93221

Sato, Juichi

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Ban, Nobutaro

× Ban, Nobutaro

WEKO 93222

Ban, Nobutaro

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キーワード
主題Scheme Other
主題 TAFRO syndrome
キーワード
主題Scheme Other
主題 immunosuppression
キーワード
主題Scheme Other
主題 course of treatment
キーワード
主題Scheme Other
主題 disseminated candidiasis
キーワード
主題Scheme Other
主題 hemophagocytic lymphohistiocytosis
抄録
内容記述 TAFRO syndrome is a novel disease concept characterized by Thrombocytopenia, Anasarca, myelo-Fibrosis, Renal dysfunction, Organomegaly, multiple lymphadenopathy and a histopathological pattern of atypical Castleman’s disease. A 58-year-old man was diagnosed as TAFRO syndrome by clinical and histopathological findings. After receiving intensive immunosuppressive therapy, his thrombocytopenia and anasarca had not improved. He developed complications such as methicillin-resistant Staphylococcus aureus sepsis, gastrointestinal bleeding, peritonitis caused by Stenotrophomonas maltophilia, gastrointestinal perforation, and disseminated candidiasis resulting in death. Autopsy revealed disseminated candidiasis and hemophagocytic lymphohistiocytosis, with no evidence of TAFRO syndrome. During treatment, we regarded his lasting thrombocytopenia and anasarca as insufficient control of TAFRO syndrome. However, the autopsy revealed that thrombocytopenia was caused by secondary hemophagocytic lymphohistiocytosis caused by over-immunosuppression. We reviewed the published literature to identify indicators of adequate treatment, which suggested improvement of platelet count and anasarca several weeks after initial therapy. This indicated that we could not depend on the platelet count and anasarca in acute medical care after initial treatment. We should treat TAFRO syndrome based on patients’ clinical status and obviate the risk of treatment-related complications caused by over-immunosuppression.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.81.3.519
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/813.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 81, 号 3, p. 519-528, 発行日 2019-08
著者版フラグ
値 publisher
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