{"_buckets": {"deposit": "c8402f52-1bec-432c-8c9d-ea97ca2486aa"}, "_deposit": {"id": "28483", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "28483"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00028483"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "930", "bibliographicPageStart": "919", "bibliographicVolumeNumber": "39", "bibliographic_titles": [{"bibliographic_title": "Journal of Applied Toxicology"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Glutathione (GSH) is one of the most extensively studied tripeptides. The roles for GSH in redox signaling, detoxification of xenobiotics and antioxidant defense have been investigated. A drug\u2010induced rhabdomyolysis mouse model was recently established in L\u2010buthionine\u2010(S,R)\u2010sulfoximine (BSO; a GSH synthesis inhibitor)\u2010treated normal mice by co\u2010administration of antibacterial drug and statin. In these models, mild kidney injury was observed in the BSO only\u2010treated mice. Therefore, in this study, we studied kidney injury in the GSH\u2010depleted mouse. BSO was intraperitoneally administered twice a day for 7 days to normal mice. The maximum level of plasma creatine phosphokinase (351 487 \u00b1 53 815 U/L) was shown on day 8, and that of aspartate aminotransferase was shown on day 6. Increased levels of blood urea nitrogen, plasma creatinine, urinary kidney injury molecule\u20101 and urinary creatinine were observed. An increase of mRNA expression level of renal lipocalin 2/neutrophil gelatinase\u2010associated lipocalin was observed. Degeneration and necrosis in the skeletal muscle and high concentrations of myoglobin (Mb) in blood (347\u2010203 925 ng/mL) and urine (2.5\u201068 583 ng/mL) with large interindividual variability were shown from day 5 of BSO administration. Mb\u2010stained regions in the renal tubule and renal cast were histologically observed. In this study, the GSH\u2010depletion treatment established an acute kidney injury mouse model due to Mb release from the damaged skeletal muscle. This mouse model would be useful for predicting potential acute kidney injury risks in non\u2010clinical drug development.", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u30d5\u30a1\u30a4\u30eb\u516c\u958b\uff1a2020-06-01", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Wiley"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1002/jat.3780", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\"This is the peer reviewed version of the following article: [Matsubara, A, Oda, S, Jia, R, Yokoi, T. Acute kidney injury model established by systemic glutathione depletion in mice. J Appl Toxicol. 2019; 39: 919\u2013 930. https://doi.org/10.1002/jat.3780], which has been published in final form at [https://doi.org/10.1002/jat.3780]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.\""}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0260-437X", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Matsubara, Akiko"}], "nameIdentifiers": [{"nameIdentifier": "93365", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oda, Shingo"}], "nameIdentifiers": [{"nameIdentifier": "93366", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Jia, Ru"}], "nameIdentifiers": [{"nameIdentifier": "93367", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yokoi, Tsuyoshi"}], "nameIdentifiers": [{"nameIdentifier": "93368", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-06-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "appendPDF.pdf", "filesize": [{"value": "4.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 4600000.0, "url": {"label": "appendPDF", "url": "https://nagoya.repo.nii.ac.jp/record/28483/files/appendPDF.pdf"}, "version_id": "0707a3f4-5a9f-49bb-b06e-fd184f231c3c"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "acute kidney injury", "subitem_subject_scheme": "Other"}, {"subitem_subject": "animal model", "subitem_subject_scheme": "Other"}, {"subitem_subject": "BSO", "subitem_subject_scheme": "Other"}, {"subitem_subject": "glutathione", "subitem_subject_scheme": "Other"}, {"subitem_subject": "myoglobin", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Acute kidney injury model established by systemic glutathione depletion in mice", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Acute kidney injury model established by systemic glutathione depletion in mice"}]}, "item_type_id": "10", "owner": "1", "path": ["499/500/501"], "permalink_uri": "http://hdl.handle.net/2237/00030674", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2019-09-11"}, "publish_date": "2019-09-11", "publish_status": "0", "recid": "28483", "relation": {}, "relation_version_is_last": true, "title": ["Acute kidney injury model established by systemic glutathione depletion in mice"], "weko_shared_id": null}