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Adaptor functions of the Ca2+-binding protein ALG-2 in protein transport from the endoplasmic reticulum
http://hdl.handle.net/2237/00030679
http://hdl.handle.net/2237/0003067924514c43-81f0-4a16-87c8-cf99c4da1bd3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
2019_BBB_83_20_HidekiShibata (964.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-09-11 | |||||
| タイトル | ||||||
| タイトル | Adaptor functions of the Ca2+-binding protein ALG-2 in protein transport from the endoplasmic reticulum | |||||
| 言語 | en | |||||
| 著者 |
Shibata, Hideki
× Shibata, Hideki |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | This is an Accepted Manuscript of an article published by Taylor & Francis Group in Bioscience, Biotechnology, and Biochemistry on 27/09/2018, available online: http://www.tandfonline.com/10.1080/09168451.2018.1525274. | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Apoptosis-linked gene 2 (ALG-2) is a Ca2+-binding protein with five repetitive EF-hand motifs, named penta-EF-hand (PEF) domain. It interacts with various target proteins and functions as a Ca2+-dependent adaptor in diverse cellular activities. In the cytoplasm, ALG-2 is predominantly localized to a specialized region of the endoplasmic reticulum (ER), called the ER exit site (ERES), through its interaction with Sec31A. Sec31A is an outer coat protein of coat protein complex II (COPII) and is recruited from the cytosol to the ERES to form COPII-coated transport vesicles. I will overview current knowledge of the physiological significance of ALG-2 in regulating ERES localization of Sec31A and the following adaptor functions of ALG-2, including bridging Sec31A and annexin A11 to stabilize Sec31A at the ERES, polymerizing the Trk-fused gene (TFG) product, and linking MAPK1-interacting and spindle stabilizing (MISS)-like (MISSL) and microtubule-associated protein 1B (MAP1B) to promote anterograde transport from the ER. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Published online: 27 Sep 2018 ファイル公開：2019/09/27 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Taylor & Francis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1080/09168451.2018.1525274 | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0916-8451 | |||||
| 書誌情報 |
en : Bioscience, Biotechnology, and Biochemistry 巻 83, 号 1, p. 20-32, 発行日 2019 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
