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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Multimodality therapy for thymoma patients with pleural dissemination

http://hdl.handle.net/2237/00030694
http://hdl.handle.net/2237/00030694
87153a77-ca6a-4261-9217-435f6c0afba6
名前 / ファイル ライセンス アクション
GTCS2018.pdf GTCS2018 (293.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-09-19
タイトル
タイトル Multimodality therapy for thymoma patients with pleural dissemination
言語 en
著者 Nakamura, Shota

× Nakamura, Shota

WEKO 93490

en Nakamura, Shota

Search repository
Kawaguchi, Koji

× Kawaguchi, Koji

WEKO 93491

en Kawaguchi, Koji

Search repository
Fukui, Takayuki

× Fukui, Takayuki

WEKO 93492

en Fukui, Takayuki

Search repository
Hakiri, Shuhei

× Hakiri, Shuhei

WEKO 93493

en Hakiri, Shuhei

Search repository
Ozeki, Naoki

× Ozeki, Naoki

WEKO 93494

en Ozeki, Naoki

Search repository
Mori, Shunsuke

× Mori, Shunsuke

WEKO 93495

en Mori, Shunsuke

Search repository
Goto, Masaki

× Goto, Masaki

WEKO 93496

en Goto, Masaki

Search repository
Hashimoto, Kumiko

× Hashimoto, Kumiko

WEKO 93497

en Hashimoto, Kumiko

Search repository
Ito, Toshinari

× Ito, Toshinari

WEKO 93498

en Ito, Toshinari

Search repository
Yokoi, Kohei

× Yokoi, Kohei

WEKO 93499

en Yokoi, Kohei

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 “This is a post-peer-review, pre-copyedit version of an article published in [General Thoracic and Cardiovascular Surgery]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s11748-018-01054-7”.
キーワード
主題Scheme Other
主題 Thymic malignancy
キーワード
主題Scheme Other
主題 Thymoma
キーワード
主題Scheme Other
主題 Multidisciplinary treatment
キーワード
主題Scheme Other
主題 Pleural dissemination
キーワード
主題Scheme Other
主題 Induction chemotherapy
抄録
内容記述 Background: Although multidisciplinary treatment is recommended for patients with advanced stage and recurrent thymoma, a detailed treatment strategy remains controversial. We have performed a multimodality therapy of induction chemotherapy (CAMP therapy: cisplatin, doxorubicin, and methylprednisolone) combined with surgery for those patients. We now conducted a retrospective study for investigating the results of this multimodality therapy for thymoma patients with pleural dissemination. Patients and methods: Between 2003 and 2017, 201 patients underwent surgical resection for thymomas. Twenty-six of them received induction CAMP therapy followed by surgery, and 19 of them with pleural dissemination were enrolled in this study. Those cohort were divided into 2 groups by employing surgical procedures: extrapleural pneumonectomy (EPP) group (n = 10) and resection of plural dissemination (RPD) group (n = 9). Results: The median age of all patients was 49 years. Based on the WHO classification, the histological diagnoses of those thymomas were as follows: Type B1 (n = 1), Type B2 (n = 13), and Type B3 (n = 5). Seven patients were complicated with myasthenia gravis (MG). Clinical stage of the 13 primary cases based on the Masaoka classification were stage IV, and the remaining six cases had recurrent pleural dissemination after surgery. Partial response in induction CAMP therapy was obtained in 78.9% (n = 15) of the patients. Adverse events (Grade 4) occurred in 2 patients (10.5%). Postoperative complications (Grade 4) were observed in 2 patients (10.5%). In all of the enrolled patients, the five-year overall survival rate (5Y-OS) and 5-year progression-free survival rate (5Y-PFS) were 76.7% and 55.1%, respectively. In the EPP group, 5Y-OS and 5Y-PFS were 83.3% and 83.3%, respectively, and in the RPD group, 70.0% and 29.6%, respectively. Conclusions: Multidisciplinary treatment using induction CAMP therapy and surgical resection for thymoma patients with pleural dissemination was effective and feasible. Because of the low recurrent rate of disease, young patients with good cardiopulmonary function and well-controlled MG might be good candidates for EPP.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2020/06/01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s11748-018-01054-7
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 1863-6705
書誌情報 en : General Thoracic and Cardiovascular Surgery

巻 67, 号 6, p. 524-529, 発行日 2019-06
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