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Role of the BDNF-TrkB pathway in KCC2 regulation and rehabilitation following neuronal injury: A mini review
http://hdl.handle.net/2237/00030884
http://hdl.handle.net/2237/00030884a1497c6a-924b-480f-a19e-2e266b83d8db
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
reviewed paper_190301 (5.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-11-14 | |||||
| タイトル | ||||||
| タイトル | Role of the BDNF-TrkB pathway in KCC2 regulation and rehabilitation following neuronal injury: A mini review | |||||
| 言語 | en | |||||
| 著者 |
Lee-Hotta, Sachiko
× Lee-Hotta, Sachiko× Uchiyama, Yasushi× Kametaka, Satoshi |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | BDNF-TrkB pathway | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | KCC2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Spasticity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Spinal cord injury | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In most mature neurons, low levels of intracellular Cl− concentrations ([Cl−]i) are maintained by channels and transporters, particularly the K+-Cl- cotransporter 2 (KCC2), which is the only Cl− extruder in most neurons. Recent studies have implicated KCC2 expression in the molecular mechanisms underlying neuronal disorders, such as spasticity, epilepsy and neuropathic pain. Alterations in KCC2 expression have been associated with brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB). The present review summarizes recent progress regarding the roles of Cl− regulators in immature and mature neurons. Moreover, we focus on the role of KCC2 regulation via the BDNF-TrkB pathway in spinal cord injury and rehabilitation, as prior studies have shown that the BDNF-TrkB pathway can affect both the pathological development and functional amelioration of spinal cord injuries. Evidence suggests that rehabilitation using active exercise and mechanical stimulation can attenuate spasticity and neuropathic pain in animal models, likely due to the upregulation of KCC2 expression via the BDNF-TrkB pathway. Moreover, research suggests that such rehabilitation efforts may recover KCC2 expression without the use of exogenous BDNF. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ファイル公開：2020-09-01 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.neuint.2019.04.003 | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0197-0186 | |||||
| 書誌情報 |
en : Neurochemistry International 巻 128, p. 32-38, 発行日 2019-09 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
