{"_buckets": {"deposit": "bde4533c-1d3c-418d-b43e-0a8f01898e1c"}, "_deposit": {"id": "28696", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "28696"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00028696"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-09", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "38", "bibliographicPageStart": "32", "bibliographicVolumeNumber": "128", "bibliographic_titles": [{"bibliographic_title": "Neurochemistry International"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "In most mature neurons, low levels of intracellular Cl\u2212 concentrations ([Cl\u2212]i) are maintained by channels and transporters, particularly the K+-Cl- cotransporter 2 (KCC2), which is the only Cl\u2212 extruder in most neurons. Recent studies have implicated KCC2 expression in the molecular mechanisms underlying neuronal disorders, such as spasticity, epilepsy and neuropathic pain. Alterations in KCC2 expression have been associated with brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB). The present review summarizes recent progress regarding the roles of Cl\u2212 regulators in immature and mature neurons. Moreover, we focus on the role of KCC2 regulation via the BDNF-TrkB pathway in spinal cord injury and rehabilitation, as prior studies have shown that the BDNF-TrkB pathway can affect both the pathological development and functional amelioration of spinal cord injuries. Evidence suggests that rehabilitation using active exercise and mechanical stimulation can attenuate spasticity and neuropathic pain in animal models, likely due to the upregulation of KCC2 expression via the BDNF-TrkB pathway. Moreover, research suggests that such rehabilitation efforts may recover KCC2 expression without the use of exogenous BDNF.", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u30d5\u30a1\u30a4\u30eb\u516c\u958b\uff1a2020-09-01", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.neuint.2019.04.003", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0197-0186", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Lee-Hotta, Sachiko"}], "nameIdentifiers": [{"nameIdentifier": "94192", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Uchiyama, Yasushi"}], "nameIdentifiers": [{"nameIdentifier": "94193", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kametaka, Satoshi"}], "nameIdentifiers": [{"nameIdentifier": "94194", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-09-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "reviewed paper_190301.pdf", "filesize": [{"value": "5.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 5000000.0, "url": {"label": "reviewed paper_190301", "url": "https://nagoya.repo.nii.ac.jp/record/28696/files/reviewed paper_190301.pdf"}, "version_id": "fa282499-808c-4f29-9e75-2c46f97eeb8d"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "BDNF-TrkB pathway", "subitem_subject_scheme": "Other"}, {"subitem_subject": "KCC2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Spasticity", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Spinal cord injury", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Role of the BDNF-TrkB pathway in KCC2 regulation and rehabilitation following neuronal injury: A mini review", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Role of the BDNF-TrkB pathway in KCC2 regulation and rehabilitation following neuronal injury: A mini review"}]}, "item_type_id": "10", "owner": "1", "path": ["499/500/501"], "permalink_uri": "http://hdl.handle.net/2237/00030884", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2019-11-14"}, "publish_date": "2019-11-14", "publish_status": "0", "recid": "28696", "relation": {}, "relation_version_is_last": true, "title": ["Role of the BDNF-TrkB pathway in KCC2 regulation and rehabilitation following neuronal injury: A mini review"], "weko_shared_id": null}