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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 81(4)

Predictors of denosumab efficacy in treating osteoporosis in patients with rheumatoid arthritis: a Japanese multicenter study

https://doi.org/10.18999/nagjms.81.4.571
https://doi.org/10.18999/nagjms.81.4.571
fe56d772-0e3e-42d5-b65c-35e7f4fd9f1d
名前 / ファイル ライセンス アクション
04_Hattori.pdf 04_Hattori.pdf (992.9 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2019-11-26
タイトル
タイトル Predictors of denosumab efficacy in treating osteoporosis in patients with rheumatoid arthritis: a Japanese multicenter study
著者 Hattori, Kyosuke

× Hattori, Kyosuke

WEKO 94397

Hattori, Kyosuke

Search repository
Hirano, Yuji

× Hirano, Yuji

WEKO 94398

Hirano, Yuji

Search repository
Kanayama, Yasuhide

× Kanayama, Yasuhide

WEKO 94399

Kanayama, Yasuhide

Search repository
Takahashi, Nobunori

× Takahashi, Nobunori

WEKO 94400

Takahashi, Nobunori

Search repository
Ishiguro, Naoki

× Ishiguro, Naoki

WEKO 94401

Ishiguro, Naoki

Search repository
Kojima, Toshihisa

× Kojima, Toshihisa

WEKO 94402

Kojima, Toshihisa

Search repository
キーワード
主題Scheme Other
主題 rheumatoid arthritis
キーワード
主題Scheme Other
主題 osteoporosis
キーワード
主題Scheme Other
主題 denosumab
キーワード
主題Scheme Other
主題 bone mineral density
キーワード
主題Scheme Other
主題 biologics
抄録
内容記述 We investigated 2-year outcomes of denosumab treatment for osteoporosis in patients with rheumatoid arthritis (RA) and predictors of good outcomes. Study participants were 74 females treated with denosumab for 24 months. After investigating baseline demographics and overall time course for each patient, we divided all cases into two groups according to percent change (%) in bone mineral density (BMD) of lumbar spine (LS-) and total hip (TH-) at 24 months (-24m); two thirds of the patients were allocated to the good outcome group (LS-GO and TH-GO), and the other third to the non-good outcome group (LS-NG and TH-NG). We performed multivariate analysis to confirm predictors of greater increases in LS- and TH-BMD. LS-BMD-24m and TH-BMD-24m increased significantly from baseline. We observed greater %LS-BMD-24m in LS-GO group than in LS-NG group, while %TH-BMD-24m showed no significant group-dependent difference. N-terminal propeptide of type 1 collagen (P1NP) and tartrate-resistant acid phosphatase (TRACP)-5b decreased more in LS-GO group than in LS-NG group at each time point. We observed greater %TH-BMD-24m in TH-GO group than in TH-NG group, while %LS-BMD-24m showed no significant group-dependent difference. Only P1NP-6m showed a larger decrease in TH-GO group relative to TH-NG group. Multivariate analysis confirmed that the larger decrease in P1NP-6m was associated with the greater increase in LS-BMD-24m, while the combined use of biologics was associated with the greater increase in TH-BMD-24m. In conclusions, denosumab increased BMD in RA patients with osteoporosis. The combined use of biologics and denosumab may provide useful treatment options.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.81.4.571
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/814.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 81, 号 4, p. 571-585, 発行日 2019-11
著者版フラグ
値 publisher
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