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Elevated serum creatine kinase in the early stage of sporadic amyotrophic lateral sclerosis
http://hdl.handle.net/2237/00031507
http://hdl.handle.net/2237/00031507f8f548cd-6fd4-4bc6-814a-a132ec98e322
| 名前 / ファイル | ライセンス | アクション |
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main_manuscript_revised_Ito_et_al_AAM (1.0 MB)
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supplemental.data.revised_ Ito_et_al (57.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2020-02-14 | |||||
| タイトル | ||||||
| タイトル | Elevated serum creatine kinase in the early stage of sporadic amyotrophic lateral sclerosis | |||||
| 言語 | en | |||||
| 著者 |
Ito, Daisuke
× Ito, Daisuke× Hashizume, Atsushi× Hijikata, Yasuhiro× Yamada, Shinichiro× Iguchi, Yohei× Iida, Madoka× Kishimoto, Yoshiyuki× Moriyoshi, Hideyuki× Hirakawa, Akihiro× Katsuno, Masahisa |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | “This is a post-peer-review, pre-copyedit version of an article published in [Journal of Neurology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00415-019-09507-6”. | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Amyotrophic lateral sclerosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Creatine kinase | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Biomarker | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: To assess the changes of muscle-related biomarkers at the early stage of amyotrophic lateral sclerosis, and to confirm these findings in an experimental animal model. Methods: Thirty-nine subjects with sporadic amyotrophic lateral sclerosis and 20 healthy controls were enrolled and longitudinally evaluated. We evaluated serum creatine kinase and creatinine levels and appendicular lean soft-tissue mass using dual X-ray absorptiometry. The levels of biomarkers at early ALS stages were estimated using linear mixed models with unstructured correlation and random intercepts. We also analyzed the longitudinal changes of serum creatine kinase and creatinine, together with the mRNA levels of acetylcholine receptor subunit γ (Chrng) and muscle-associated receptor tyrosine kinase, markers of denervation, in the gastrocnemius muscle of superoxide dismutase 1 (SOD1)G93A transgenic mice, an animal model of amyotrophic lateral sclerosis. Results: The estimated levels of creatine kinase were higher in subjects with amyotrophic lateral sclerosis at the early stage than in healthy controls, although the estimated appendicular lean soft-tissue mass and creatinine levels were equivalent between both groups, suggesting that the elevation of creatine kinase precedes both muscular atrophy and subjective motor symptoms in sporadic amyotrophic lateral sclerosis. In SOD1G93A mice, the serum levels of creatine kinase were elevated at 9 weeks of age (peri-onset) when Chrng started to be up-regulated, and were then down-regulated at 15 weeks of age, consistent with the clinical data from patients with sporadic amyotrophic lateral sclerosis. Interpretation: Creatine kinase elevation precedes muscular atrophy and reflects muscle denervation at the early stage. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ファイル公開：2020/12/01 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Springer | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1007/s00415-019-09507-6 | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0340-5354 | |||||
| 書誌情報 |
en : Journal of Neurology 巻 266, 号 12, p. 2952-2961, 発行日 2019-12 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
