{"_buckets": {"deposit": "92c11742-833e-4207-aaba-a6a5bf61dab8"}, "_deposit": {"id": "29340", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "29340"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00029340", "sets": ["322"]}, "author_link": ["96186", "96187", "96188", "96189", "96190", "96191", "96192"], "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "352", "bibliographicPageStart": "340", "bibliographicVolumeNumber": "158", "bibliographic_titles": [{"bibliographic_title": "Immunology", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Siglecs are cell surface lectins that recognize sialic acids and are primarily expressed in hematopoietic cells. Previous studies showed that some Siglecs regulate macrophage function. In the present study, we examined the induction and putative roles of mouse Siglec‐F in bone‐marrow‐derived macrophages in mice. A quantitative RT‐PCR analysis showed that the basal expression of Siglec‐F was weak in bone‐marrow‐derived macrophages differentiated by macrophage colony‐stimulating factor. However, a 24‐hr stimulation with granulocyte–macrophage colony‐stimulating factor (GM‐CSF) enhanced Siglec‐F expression. GM‐CSF also enhanced Siglec‐F expression in thioglycollate‐induced peritoneal macrophages. The inhibition of signal transducer and activator of transcription 5 (STAT5), but not that of phosphoinositide 3‐kinase or mitogen‐activated protein kinase kinase, significantly reduced the induction of Siglec‐F. Interleukin‐3, which uses a common β‐chain shared with the GM‐CSF receptor to stimulate the STAT5 pathway, also enhanced Siglec‐F expression. The knockdown of Siglec‐F by a specific small interfering RNA enhanced GM‐CSF‐induced STAT5 phosphorylation, suggesting that Siglec‐F down‐regulates its own expression upon prolonged GM‐CSF stimulation. Furthermore, the knockdown of Siglec‐F reduced the STAT6 phosphorylation and expression of arginase‐1 in interleukin‐4‐stimulated macrophages. These results suggest that Siglec‐F fine‐tunes the immune responses of macrophages.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "ファイル公開：2020-12-01", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Wiley", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1111/imm.13121", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This is the peer reviewed version of the following article: [Tateyama, H., Murase, Y., Higuchi, H., Inasaka, Y., Kaneoka, H., Iijima, S. and Nishijima, K.‐i. (2019), Siglec‐F is induced by granulocyte–macrophage colony‐stimulating factor and enhances interleukin‐4‐induced expression of arginase‐1 in mouse macrophages. Immunology, 158: 340-352. doi:10.1111/imm.13121], which has been published in final form at [https://doi.org/10.1111/imm.13121]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.", "subitem_rights_language": "en"}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN（print）", "attribute_value_mlt": [{"subitem_source_identifier": "0019-2805", "subitem_source_identifier_type": "PISSN"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tateyama, Hiroyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96186", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murase, Yusuke", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96187", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Hiroshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96188", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Inasaka, Yui", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96189", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kaneoka, Hidenori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96190", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iijima, Shinji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96191", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishijima, Ken‐ichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96192", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Siglec-F_is_induced_by_GM-CSF.pdf", "filesize": [{"value": "2.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 2400000.0, "url": {"label": "Siglec-F_is_induced_by_GM-CSF", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/29340/files/Siglec-F_is_induced_by_GM-CSF.pdf"}, "version_id": "ba580605-e5df-49be-9160-3f1754208ac1"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Siglec‐F is induced by granulocyte–macrophage colony‐stimulating factor and enhances interleukin‐4‐induced expression of arginase‐1 in mouse macrophages", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Siglec‐F is induced by granulocyte–macrophage colony‐stimulating factor and enhances interleukin‐4‐induced expression of arginase‐1 in mouse macrophages", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["322"], "permalink_uri": "http://hdl.handle.net/2237/00031527", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-02-19"}, "publish_date": "2020-02-19", "publish_status": "0", "recid": "29340", "relation": {}, "relation_version_is_last": true, "title": ["Siglec‐F is induced by granulocyte–macrophage colony‐stimulating factor and enhances interleukin‐4‐induced expression of arginase‐1 in mouse macrophages"], "weko_shared_id": -1}