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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 82(1)

Micro-computed tomography images of lung adenocarcinoma: detection of lepidic growth patterns

https://doi.org/10.18999/nagjms.82.1.25
https://doi.org/10.18999/nagjms.82.1.25
2c7b09f7-d349-4dd0-8dd6-8b851fa443c3
名前 / ファイル ライセンス アクション
04_Nakamura.pdf 04_Nakamura.pdf (11.3 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2020-02-26
タイトル
タイトル Micro-computed tomography images of lung adenocarcinoma: detection of lepidic growth patterns
著者 Nakamura, Shota

× Nakamura, Shota

WEKO 96279

Nakamura, Shota

Search repository
Mori, Kensaku

× Mori, Kensaku

WEKO 96280

Mori, Kensaku

Search repository
Iwano, Shingo

× Iwano, Shingo

WEKO 96281

Iwano, Shingo

Search repository
Kawaguchi, Koji

× Kawaguchi, Koji

WEKO 96282

Kawaguchi, Koji

Search repository
Fukui, Takayuki

× Fukui, Takayuki

WEKO 96283

Fukui, Takayuki

Search repository
Hakiri, Shuhei

× Hakiri, Shuhei

WEKO 96284

Hakiri, Shuhei

Search repository
Ozeki, Naoki

× Ozeki, Naoki

WEKO 96285

Ozeki, Naoki

Search repository
Oda, Masahiro

× Oda, Masahiro

WEKO 96286

Oda, Masahiro

Search repository
Yokoi, Kohei

× Yokoi, Kohei

WEKO 96287

Yokoi, Kohei

Search repository
キーワード
主題Scheme Other
主題 Lung cancer
キーワード
主題Scheme Other
主題 Computed tomography
キーワード
主題Scheme Other
主題 Micro-computed tomography
キーワード
主題Scheme Other
主題 Three dimensional reconstruction
キーワード
主題Scheme Other
主題 Pathological diagnosis
抄録
内容記述 Micro-computed tomography (μCT) provides extremely high-resolution images of samples and can be employed as a non-destructive inspection tool. Using μCT, we can obtain images comparable with microscopic images. In this work, we have attempted to take high-resolution images of the human lung using μCT. Compared to clinical high-resolution computed tomography (HRCT) images of living body (in-vivo imaging), we can obtain extremely high-resolution images by μCT of ex-vivo tissues (resected lungs) as three-dimensional data. The purpose of this study was to distinguish between areas of normal lung and lung cancer by μCT images in order to study the feasibility of cancer diagnosis using this novel radiological image modality. Ten resected human lungs containing primary cancer were fixed by Heitzman’s methods to obtain high-resolution μCT images. After fixation of the lung, images of the specimens were taken by μCT between January 2016 and November 2017. The imaging conditions were tube voltage: 90 kV and tube current: 110 μA. To compare details of images gained by conventional HRCT and μCT, we measured the thickness of the alveolar walls of the normal lung area and the cancer area of which alveoli might be replaced by tumor cells, and compared their appearance by means of histopathological images. All the nodules were diagnosed as adenocarcinoma. The median whole tumor size was 18 mm (9 mm–24 mm). Each specimen was clearly divided into areas of normal alveolar wall and of thickened alveolar wall on μCT ‘visually’. Median thickness of alveolar walls of the normal lung was 0.037 mm (0.034 mm–0.048 mm), and that of the cancer area was 0.084 mm (0.074 mm–0.094 mm); there was a statistically significant difference between both thicknesses by Student’s t-test (P < 0.01). The area of thickened alveolar walls on μCT corresponded well with the area of microscopically lepidic growth patterns of adenocarcinoma. We found that μCT images could be correctly divided by alveolar walls into normal lung area and lung cancer area. Further detailed investigations with regard to μCT are needed to make comparable histological diagnoses using μCT images with conventional microscopic methods of pathological diagnoses.
内容記述タイプ Abstract
内容記述
内容記述 This work was supported by JSPS KAKENHI Grant Number 15H01116 Grant-in-Aid for Scientific Research on Innovative Areas.
内容記述タイプ Other
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.82.1.25
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/821.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 82, 号 1, p. 25-31, 発行日 2020-02
著者版フラグ
値 publisher
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