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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 82(1)

Stanniocalcin-1 mRNA expression in soft-tissue tumors

https://doi.org/10.18999/nagjms.82.1.85
cfab9e24-98cf-4404-85e0-4acdac1473cc
名前 / ファイル ライセンス アクション
11_Yamagishi.pdf 11_Yamagishi.pdf (823.2 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2020-02-26
タイトル
タイトル Stanniocalcin-1 mRNA expression in soft-tissue tumors
著者 Yamagishi, Tetsuro

× Yamagishi, Tetsuro

WEKO 96333

Yamagishi, Tetsuro

Search repository
Kawashima, Hiroyuki

× Kawashima, Hiroyuki

WEKO 96334

Kawashima, Hiroyuki

Search repository
Ogose, Akira

× Ogose, Akira

WEKO 96335

Ogose, Akira

Search repository
Ariizumi, Takashi

× Ariizumi, Takashi

WEKO 96336

Ariizumi, Takashi

Search repository
Oike, Naoki

× Oike, Naoki

WEKO 96337

Oike, Naoki

Search repository
Sasaki, Taro

× Sasaki, Taro

WEKO 96338

Sasaki, Taro

Search repository
Hatano, Hiroshi

× Hatano, Hiroshi

WEKO 96339

Hatano, Hiroshi

Search repository
Endo, Naoto

× Endo, Naoto

WEKO 96340

Endo, Naoto

Search repository
キーワード
主題Scheme Other
主題 Stanniocalcin-1
キーワード
主題Scheme Other
主題 soft tissue tumor
キーワード
主題Scheme Other
主題 expression
抄録
内容記述 Stanniocalcin-1 (STC1) is a glycoprotein that was originally identified as a calcium-regulating hormone in bony fish, and that has been shown to also critically mediate cell growth, proliferation and differentiation, etc. in humans. Increased STC1 expression levels have been previously detected in different human cancer samples, such as those isolated from lung, breast, ovary, colon, pancreas, and liver tumors; thus, the present study evaluated STC1 expression in various soft-tissue tumors. STC1 mRNA isolated from 16 cell lines and 186 clinical soft-tissue tumor specimens were analyzed via quantitative real-time PCR, and the calculated expression levels were normalized to those exhibited by STC1-expressing MDA-MB-231 cells. The results of these analyses did not reveal any specific histological tumor types that displayed significantly increased STC1 expression; however, they did not indicate that STC1 expression was significantly higher in malignant compared to benign soft-tissue tumors. Furthermore, in adipocytic tumors, STC1 expression in dedifferentiated liposarcomas was found to be highest and lowest in lipoma tissues, respectively, suggesting that adipocytic tumors may express increasely high levels of STC1 mRNA as they become histologically more advanced. STC1 expression correlates with the malignancy grade in soft-tissue tumors.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.82.1.85
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
関連識別子
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/821.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 82, 号 1, p. 85-92, 発行日 2020-02
著者版フラグ
値 publisher
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