ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "eba8a423-63e3-496e-a9c2-e4d29172306d"}, "_deposit": {"id": "29389", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "29389"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00029389", "sets": ["501"]}, "author_link": ["96486", "96487", "96488", "96489", "96490", "96491", "96492", "96493"], "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "315", "bibliographicPageStart": "304", "bibliographicVolumeNumber": "37", "bibliographic_titles": [{"bibliographic_title": "Food Additives \u0026 Contaminants: Part A", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "There is a growing appreciation of the importance of determining chemical exposure levels in early childhood, as well as in embryonic and foetal life, which are now widely believed to be essential for gaining insight into potential health risks associated with these chemicals. To facilitate the assessment of exposure to neonicotinoid insecticides (NEOs) in non-toilet-trained children, a new method using disposable diapers (nappies) was developed for the simultaneous determination of the NEOs acetamiprid and its metabolite N-desmethylacetamiprid, clothianidin, dinotefuran, imidacloprid, thiacloprid, and thiamethoxam (NEO biomarkers). The urine absorbed in disposable diapers was extracted with acetone (diaper urine) and was cleaned using a solid-phase extraction column, before analysis with LC-MS/MS. The absolute recoveries of NEO biomarkers were 19–50%. Good results were observed for the linearity of the matrix-matched calibration curves (r^2 = 0.983–0.996; concentration range LOQ-20 µg L^−1) and the precision of intra-day (% relative standard deviation (%RSD): 3.3–12.7%) and inter-day (%RSD: 4.3–19.5%) analyses. The lowest and highest limits of detection of the developed method were 0.07 µg L^−1 for acetamiprid and 0.75 µg L^−1 for clothianidin. The developed method was applied for the evaluation of fifty diapered three-year-old children in Japan. Importantly, the study revealed relatively high detection rates for dinotefuran and N-desmethylacetamiprid; 84% and 78% respectively. The highest geometric mean of dinotefuran urinary concentration was 2.01 µg L^−1. Thus, a method for determining NEO biomarkers in urine extracted from disposable diapers was established. This is the first report on the simultaneous quantitative analysis of NEO biomarkers of diaper-absorbed urine samples.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Published online: 11 Dec 2019 ファイル公開:2020/12/11", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Taylor \u0026 Francis", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1080/19440049.2019.1696020", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This is an Accepted Manuscript of an article published by Taylor \u0026 Francis Group in Food Additives \u0026 Contaminants: Part A on 11/12/2019, available online: http://www.tandfonline.com/10.1080/19440049.2019.1696020", "subitem_rights_language": "en"}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN(print)", "attribute_value_mlt": [{"subitem_source_identifier": "1944-0049", "subitem_source_identifier_type": "PISSN"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ueyama, Jun", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96486", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aoi, Arisa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96487", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ueda, Yuko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96488", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oya, Naoko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96489", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sugiura, Yuka", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96490", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Yuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96491", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ebara, Takeshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96492", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamijima, Michihiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96493", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-11"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "marked_manuscript.pdf", "filesize": [{"value": "716.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 716600.0, "url": {"label": "marked_manuscript", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/29389/files/marked_manuscript.pdf"}, "version_id": "5ee5efc3-3091-40be-9d1b-8ac2947e20cd"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Neonicotinoid", "subitem_subject_scheme": "Other"}, {"subitem_subject": "diaper", "subitem_subject_scheme": "Other"}, {"subitem_subject": "urine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "LC-MS/MS", "subitem_subject_scheme": "Other"}, {"subitem_subject": "biomarkers", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Biomonitoring method for neonicotinoid insecticides in urine of non-toilet-trained children using LC-MS/MS", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Biomonitoring method for neonicotinoid insecticides in urine of non-toilet-trained children using LC-MS/MS", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["501"], "permalink_uri": "http://hdl.handle.net/2237/00031576", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-03-11"}, "publish_date": "2020-03-11", "publish_status": "0", "recid": "29389", "relation": {}, "relation_version_is_last": true, "title": ["Biomonitoring method for neonicotinoid insecticides in urine of non-toilet-trained children using LC-MS/MS"], "weko_shared_id": -1}
  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Biomonitoring method for neonicotinoid insecticides in urine of non-toilet-trained children using LC-MS/MS

http://hdl.handle.net/2237/00031576
http://hdl.handle.net/2237/00031576
4e8cfe21-3637-4526-8fdf-22cc1843b346
名前 / ファイル ライセンス アクション
marked_manuscript.pdf marked_manuscript (716.6 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-03-11
タイトル
タイトル Biomonitoring method for neonicotinoid insecticides in urine of non-toilet-trained children using LC-MS/MS
言語 en
著者 Ueyama, Jun

× Ueyama, Jun

WEKO 96486

en Ueyama, Jun

Search repository
Aoi, Arisa

× Aoi, Arisa

WEKO 96487

en Aoi, Arisa

Search repository
Ueda, Yuko

× Ueda, Yuko

WEKO 96488

en Ueda, Yuko

Search repository
Oya, Naoko

× Oya, Naoko

WEKO 96489

en Oya, Naoko

Search repository
Sugiura, Yuka

× Sugiura, Yuka

WEKO 96490

en Sugiura, Yuka

Search repository
Ito, Yuki

× Ito, Yuki

WEKO 96491

en Ito, Yuki

Search repository
Ebara, Takeshi

× Ebara, Takeshi

WEKO 96492

en Ebara, Takeshi

Search repository
Kamijima, Michihiro

× Kamijima, Michihiro

WEKO 96493

en Kamijima, Michihiro

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is an Accepted Manuscript of an article published by Taylor & Francis Group in Food Additives & Contaminants: Part A on 11/12/2019, available online: http://www.tandfonline.com/10.1080/19440049.2019.1696020
キーワード
主題Scheme Other
主題 Neonicotinoid
キーワード
主題Scheme Other
主題 diaper
キーワード
主題Scheme Other
主題 urine
キーワード
主題Scheme Other
主題 LC-MS/MS
キーワード
主題Scheme Other
主題 biomarkers
抄録
内容記述 There is a growing appreciation of the importance of determining chemical exposure levels in early childhood, as well as in embryonic and foetal life, which are now widely believed to be essential for gaining insight into potential health risks associated with these chemicals. To facilitate the assessment of exposure to neonicotinoid insecticides (NEOs) in non-toilet-trained children, a new method using disposable diapers (nappies) was developed for the simultaneous determination of the NEOs acetamiprid and its metabolite N-desmethylacetamiprid, clothianidin, dinotefuran, imidacloprid, thiacloprid, and thiamethoxam (NEO biomarkers). The urine absorbed in disposable diapers was extracted with acetone (diaper urine) and was cleaned using a solid-phase extraction column, before analysis with LC-MS/MS. The absolute recoveries of NEO biomarkers were 19–50%. Good results were observed for the linearity of the matrix-matched calibration curves (r^2 = 0.983–0.996; concentration range LOQ-20 µg L^−1) and the precision of intra-day (% relative standard deviation (%RSD): 3.3–12.7%) and inter-day (%RSD: 4.3–19.5%) analyses. The lowest and highest limits of detection of the developed method were 0.07 µg L^−1 for acetamiprid and 0.75 µg L^−1 for clothianidin. The developed method was applied for the evaluation of fifty diapered three-year-old children in Japan. Importantly, the study revealed relatively high detection rates for dinotefuran and N-desmethylacetamiprid; 84% and 78% respectively. The highest geometric mean of dinotefuran urinary concentration was 2.01 µg L^−1. Thus, a method for determining NEO biomarkers in urine extracted from disposable diapers was established. This is the first report on the simultaneous quantitative analysis of NEO biomarkers of diaper-absorbed urine samples.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 Published online: 11 Dec 2019 ファイル公開:2020/12/11
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Taylor & Francis
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1080/19440049.2019.1696020
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 1944-0049
書誌情報 en : Food Additives & Contaminants: Part A

巻 37, 号 2, p. 304-315, 発行日 2020
著者版フラグ
値 author
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 09:33:43.357847
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3