ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "0e62d89a-f590-4514-978d-4452e74b197b"}, "_deposit": {"id": "29391", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "29391"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00029391", "sets": ["696"]}, "author_link": ["96499", "96500", "96501", "96502", "96503", "96504", "96505", "96506", "96507", "96508", "96509", "96510", "96511", "96512"], "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-11-15", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "408", "bibliographicPageStart": "393", "bibliographicVolumeNumber": "455", "bibliographic_titles": [{"bibliographic_title": "Developmental Biology", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The cerebellum and the cerebellum-like structure in the mesencephalic tectum in zebrafish contain multiple cell types, including principal cells (i.e., Purkinje cells and type I neurons) and granule cells, that form neural circuits in which the principal cells receive and integrate inputs from granule cells and other neurons. It is largely unknown how these cells are positioned and how neural circuits form. While Reelin signaling is known to play an important role in cell positioning in the mammalian brain, its role in the formation of other vertebrate brains remains elusive. Here we found that zebrafish with mutations in Reelin or in the Reelin-signaling molecules Vldlr or Dab1a exhibited ectopic Purkinje cells, eurydendroid cells (projection neurons), and Bergmann glial cells in the cerebellum, and ectopic type I neurons in the tectum. The ectopic Purkinje cells and type I neurons received aberrant afferent fibers in these mutants. In wild-type zebrafish, reelin transcripts were detected in the internal granule cell layer, while Reelin protein was localized to the superficial layer of the cerebellum and the tectum. Laser ablation of the granule cell axons perturbed the localization of Reelin, and the mutation of both kif5aa and kif5ba, which encode major kinesin I components in the granule cells, disrupted the elongation of granule cell axons and the Reelin distribution. Our findings suggest that in zebrafish, (1) Reelin is transported from the granule cell soma to the superficial layer by axonal transport; (2) Reelin controls the migration of neurons and glial cells from the ventricular zone; and (3) Purkinje cells and type I neurons attract afferent axons during the formation of the cerebellum and the cerebellum-like structure.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "ファイル公開:2020-11-15", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.ydbio.2019.07.010", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/", "subitem_rights_language": "en"}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN(print)", "attribute_value_mlt": [{"subitem_source_identifier": "0012-1606", "subitem_source_identifier_type": "PISSN"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nimura, Takayuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96499", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Itoh, Tsubasa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96500", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hagio, Hanako", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96501", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayashi, Takuto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96502", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Di Donato, Vincenzo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96503", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takeuchi, Miki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96504", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Itoh, Takeaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96505", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Inoguchi, Fuduki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96506", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sato, Yoshikatsu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96507", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamamoto, Naoyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96508", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Katsuyama, Yu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96509", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Del Bene, Filippo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96510", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimizu, Takashi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96511", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hibi, Masahiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "96512", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-11-15"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Nimura_Dev_Biol_2019.pdf", "filesize": [{"value": "4.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 4600000.0, "url": {"label": "Nimura_Dev_Biol_2019", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/29391/files/Nimura_Dev_Biol_2019.pdf"}, "version_id": "33d4588e-94ab-4c75-9389-53e7461c9757"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Reelin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cerebellum", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cerebellum-like structure", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Mesencephalic tectum", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Layer formation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Neural circuit formation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Axonal transport", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Zebrafish", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Role of Reelin in cell positioning in the cerebellum and the cerebellum-like structure in zebrafish", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Role of Reelin in cell positioning in the cerebellum and the cerebellum-like structure in zebrafish", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["696"], "permalink_uri": "http://hdl.handle.net/2237/00031578", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-03-11"}, "publish_date": "2020-03-11", "publish_status": "0", "recid": "29391", "relation": {}, "relation_version_is_last": true, "title": ["Role of Reelin in cell positioning in the cerebellum and the cerebellum-like structure in zebrafish"], "weko_shared_id": -1}
  1. B100 理学部/理学研究科
  2. B100a 雑誌掲載論文
  3. 学術雑誌

Role of Reelin in cell positioning in the cerebellum and the cerebellum-like structure in zebrafish

http://hdl.handle.net/2237/00031578
http://hdl.handle.net/2237/00031578
09b4069a-6d62-46d7-b7f0-f6dbeec55e5d
名前 / ファイル ライセンス アクション
Nimura_Dev_Biol_2019.pdf Nimura_Dev_Biol_2019 (4.6 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-03-11
タイトル
タイトル Role of Reelin in cell positioning in the cerebellum and the cerebellum-like structure in zebrafish
言語 en
著者 Nimura, Takayuki

× Nimura, Takayuki

WEKO 96499

en Nimura, Takayuki

Search repository
Itoh, Tsubasa

× Itoh, Tsubasa

WEKO 96500

en Itoh, Tsubasa

Search repository
Hagio, Hanako

× Hagio, Hanako

WEKO 96501

en Hagio, Hanako

Search repository
Hayashi, Takuto

× Hayashi, Takuto

WEKO 96502

en Hayashi, Takuto

Search repository
Di Donato, Vincenzo

× Di Donato, Vincenzo

WEKO 96503

en Di Donato, Vincenzo

Search repository
Takeuchi, Miki

× Takeuchi, Miki

WEKO 96504

en Takeuchi, Miki

Search repository
Itoh, Takeaki

× Itoh, Takeaki

WEKO 96505

en Itoh, Takeaki

Search repository
Inoguchi, Fuduki

× Inoguchi, Fuduki

WEKO 96506

en Inoguchi, Fuduki

Search repository
Sato, Yoshikatsu

× Sato, Yoshikatsu

WEKO 96507

en Sato, Yoshikatsu

Search repository
Yamamoto, Naoyuki

× Yamamoto, Naoyuki

WEKO 96508

en Yamamoto, Naoyuki

Search repository
Katsuyama, Yu

× Katsuyama, Yu

WEKO 96509

en Katsuyama, Yu

Search repository
Del Bene, Filippo

× Del Bene, Filippo

WEKO 96510

en Del Bene, Filippo

Search repository
Shimizu, Takashi

× Shimizu, Takashi

WEKO 96511

en Shimizu, Takashi

Search repository
Hibi, Masahiko

× Hibi, Masahiko

WEKO 96512

en Hibi, Masahiko

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
キーワード
主題Scheme Other
主題 Reelin
キーワード
主題Scheme Other
主題 Cerebellum
キーワード
主題Scheme Other
主題 Cerebellum-like structure
キーワード
主題Scheme Other
主題 Mesencephalic tectum
キーワード
主題Scheme Other
主題 Layer formation
キーワード
主題Scheme Other
主題 Neural circuit formation
キーワード
主題Scheme Other
主題 Axonal transport
キーワード
主題Scheme Other
主題 Zebrafish
抄録
内容記述 The cerebellum and the cerebellum-like structure in the mesencephalic tectum in zebrafish contain multiple cell types, including principal cells (i.e., Purkinje cells and type I neurons) and granule cells, that form neural circuits in which the principal cells receive and integrate inputs from granule cells and other neurons. It is largely unknown how these cells are positioned and how neural circuits form. While Reelin signaling is known to play an important role in cell positioning in the mammalian brain, its role in the formation of other vertebrate brains remains elusive. Here we found that zebrafish with mutations in Reelin or in the Reelin-signaling molecules Vldlr or Dab1a exhibited ectopic Purkinje cells, eurydendroid cells (projection neurons), and Bergmann glial cells in the cerebellum, and ectopic type I neurons in the tectum. The ectopic Purkinje cells and type I neurons received aberrant afferent fibers in these mutants. In wild-type zebrafish, reelin transcripts were detected in the internal granule cell layer, while Reelin protein was localized to the superficial layer of the cerebellum and the tectum. Laser ablation of the granule cell axons perturbed the localization of Reelin, and the mutation of both kif5aa and kif5ba, which encode major kinesin I components in the granule cells, disrupted the elongation of granule cell axons and the Reelin distribution. Our findings suggest that in zebrafish, (1) Reelin is transported from the granule cell soma to the superficial layer by axonal transport; (2) Reelin controls the migration of neurons and glial cells from the ventricular zone; and (3) Purkinje cells and type I neurons attract afferent axons during the formation of the cerebellum and the cerebellum-like structure.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2020-11-15
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.ydbio.2019.07.010
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0012-1606
書誌情報 en : Developmental Biology

巻 455, 号 2, p. 393-408, 発行日 2019-11-15
著者版フラグ
値 author
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 09:35:24.143627
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3