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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 82(2)

The management of hydatidiform mole using prophylactic chemotherapy and hysterectomy for high-risk patients decreased the incidence of gestational trophoblastic neoplasia in Vietnam: a retrospective observational study

https://doi.org/10.18999/nagjms.82.2.183
https://doi.org/10.18999/nagjms.82.2.183
edfaccf1-22eb-45bb-b3c8-e094e48de566
名前 / ファイル ライセンス アクション
04_Yamamoto.pdf 04_Yamamoto.pdf (591.0 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2020-06-01
タイトル
タイトル The management of hydatidiform mole using prophylactic chemotherapy and hysterectomy for high-risk patients decreased the incidence of gestational trophoblastic neoplasia in Vietnam: a retrospective observational study
著者 Yamamoto, Eiko

× Yamamoto, Eiko

WEKO 99253

Yamamoto, Eiko

Search repository
Trinh, Tien Dat

× Trinh, Tien Dat

WEKO 99254

Trinh, Tien Dat

Search repository
Sekiya, Yoko

× Sekiya, Yoko

WEKO 99255

Sekiya, Yoko

Search repository
Tamakoshi, Koji

× Tamakoshi, Koji

WEKO 99256

Tamakoshi, Koji

Search repository
Nguyen, Xuan Phuoc

× Nguyen, Xuan Phuoc

WEKO 99257

Nguyen, Xuan Phuoc

Search repository
Nishino, Kimihiro

× Nishino, Kimihiro

WEKO 99258

Nishino, Kimihiro

Search repository
Niimi, Kaoru

× Niimi, Kaoru

WEKO 99259

Niimi, Kaoru

Search repository
Kotani, Tomomi

× Kotani, Tomomi

WEKO 99260

Kotani, Tomomi

Search repository
Kajiyama, Hiroaki

× Kajiyama, Hiroaki

WEKO 99261

Kajiyama, Hiroaki

Search repository
Shibata, Kiyosumi

× Shibata, Kiyosumi

WEKO 99262

Shibata, Kiyosumi

Search repository
Le, Quang Thanh

× Le, Quang Thanh

WEKO 99263

Le, Quang Thanh

Search repository
Kikkawa, Fumitaka

× Kikkawa, Fumitaka

WEKO 99264

Kikkawa, Fumitaka

Search repository
キーワード
主題Scheme Other
主題 post-molar gestational trophoblastic neoplasia
キーワード
主題Scheme Other
主題 hydatidiform mole
キーワード
主題Scheme Other
主題 hysterectomy
キーワード
主題Scheme Other
主題 prophylactic chemotherapy
キーワード
主題Scheme Other
主題 Vietnam
抄録
内容記述 The management of hydatidiform mole (HM) and the incidence of post-molar gestational trophoblastic neoplasia (GTN) in Vietnam has not been reported to date. This study aimed to study the incidence of HM and post-molar GTN and identify factors associated with post-molar GTN at a tertiary hospital in Vietnam. Five hundred and eighty-four patients who were treated for HM at Tu Du Hospital between January and December 2010 were included in this study. The mean age and gestational age at the first evacuation were 28.8 years old and 11.0 weeks, respectively. After the initial evacuation and pathological examination, 87 patients who were older than 40 or did not wish to have children underwent a hysterectomy, while the others underwent second curettage. All 472 patients who had human chorionic gonadotropin (hCG) ≥ 100,000 IU/L before treatment received one cycle of methotrexate with folinic acid as prophylactic chemotherapy. The incidence of HM was 11.1 per 1,000 deliveries; 47 patients (8.0%) developed post-molar GTN. Gestational week, hCG level at one week after the first evacuation, and pathological remnants were significantly associated with the development of post-molar GTN. The results of this study suggest that prophylactic chemotherapy and hysterectomy may be useful for high-risk HM patients to reduce post-molar GTN in settings in which the risk of post-molar GTN and loss to follow-up after HM are greater and hCG measurements and appropriate GTN treatments are unavailable. However, future studies on the long-term outcomes and side effects of prophylactic therapies on HM are required.
内容記述タイプ Abstract
内容記述
内容記述 This work was supported by JSPS KAKENHI (Grant Number: 15H02660).
内容記述タイプ Other
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.82.2.183
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/822.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 82, 号 2, p. 183-191, 発行日 2020-05
著者版フラグ
値 publisher
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