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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 82(2)

Unexpected radioactive iodine accumulation on whole-body scan after I-131 ablation therapy for differentiated thyroid cancer

https://doi.org/10.18999/nagjms.82.2.205
https://doi.org/10.18999/nagjms.82.2.205
b60d90c1-e2ea-4a15-a52c-ad5f21a21aba
名前 / ファイル ライセンス アクション
06_Iwano.pdf 06_Iwano.pdf (16.1 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2020-06-01
タイトル
タイトル Unexpected radioactive iodine accumulation on whole-body scan after I-131 ablation therapy for differentiated thyroid cancer
著者 Iwano, Shingo

× Iwano, Shingo

WEKO 99266

Iwano, Shingo

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Ito, Shinji

× Ito, Shinji

WEKO 99267

Ito, Shinji

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Kamiya, Shinichiro

× Kamiya, Shinichiro

WEKO 99268

Kamiya, Shinichiro

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Ito, Rintaro

× Ito, Rintaro

WEKO 99269

Ito, Rintaro

Search repository
Kato, Katsuhiko

× Kato, Katsuhiko

WEKO 99270

Kato, Katsuhiko

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Naganawa, Shinji

× Naganawa, Shinji

WEKO 99271

Naganawa, Shinji

Search repository
キーワード
主題Scheme Other
主題 ablation
キーワード
主題Scheme Other
主題 differentiated thyroid cancer
キーワード
主題Scheme Other
主題 lymph node metastasis
キーワード
主題Scheme Other
主題 radioactive iodine
キーワード
主題Scheme Other
主題 SPECT/CT
抄録
内容記述 We retrospectively evaluated the frequency of unexpected accumulation of radioactive iodine on the post-therapy whole-body scan (Rx-WBS) after radioactive iodine (RAI) ablation therapy in patients with differentiated thyroid cancer (DTC). We searched our institutional database for Rx-WBSs of DTC patients who underwent RAI ablation or adjuvant therapy between 2012 and 2019. Patients with distant metastasis diagnosed by CT or PET/CT before therapy, and those had previously received RAI therapy were excluded. In total, 293 patients (201 female and 92 male, median age 54 years) were selected. Two nuclear medicine physicians interpreted the Rx-WBS images by determining the visual intensity of radioiodine uptake by the thyroid bed, cervical and mediastinal lymph nodes, lungs, and bone. Clinical features of the patients with and without the metastatic accumulation were compared by chi-square test and median test. Logistic regression analyses were performed to compare the association between the presence of metastatic accumulation and these clinical factors. Eighty-four of 293 patients (28.7%) showed metastatic accumulation. Patients with metastatic RAI accumulation showed a significantly higher frequency of pathological N1 (pN1) and serum thyroglobulin (Tg) > 1.5 ng/ml under TSH stimulation (p = 0.035 and p = 0.031, respectively). Logistic regression analysis indicated that a serum Tg > 1.5 ng/ml was significantly correlated with the presence of metastatic accumulation (odds ratio = 1.985; p = 0.033). In conclusion, Patients with Tg > 1.5 ng/ml were more likely to show metastatic accumulation. In addition, the presence of lymph node metastasis at the initial thyroid surgery was also associated with this unexpected metastatic accumulation.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.82.2.205
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/822.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 82, 号 2, p. 205-215, 発行日 2020-05
著者版フラグ
値 publisher
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